Peer victimization and its impact on adolescent brain development and psychopathology

Quinlan, Erin Burke; Barker, Edward D.; Luo, Qiang; Banaschewski, Tobias; Bokde, Arun L.W.; Bromberg, Uli; Büchel, Christian; Desrivières, Sylvane; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Chaarani, Bader; Gowland, Penny; Heinz, Andreas; Brühl, Rüdiger; Martinot, Jean‐Luc; Martinot, Marie‐Laure Paillère; Nees, Frauke; Papadopoulos, Dimitri; Paus, Tomáš; Poustka, Luise; Hohmann, Sarah; Smolka, Michael N.; Fröhner, Juliane H.; Walter, Henrik; Whelan, Robert; Schumann, Günter

doi:10.1038/s41380-018-0297-9

Cited by 71 publications

(64 citation statements)

References 67 publications

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“…For example, peer victimization has been shown to be a contributor to mental health disorders 46,47 , even above and beyond that of family background and genetic risk 48 , but if and how the brain moderates these relationships was unknown. In IMAGEN we showed for the first time that peer victimization results in increased generalized anxiety in part by affecting the rate of structural brain development across adolescence 49 . Early interventions to reduce these exposures could mitigate the changes in brain structure underlying the development of mental disorders.…”

Section: Environmental Impact On Neural Mechanisms Of Mental Disordersmentioning

confidence: 93%

“…In addition to identifying psychopathology predictors we aim to establish longitudinal trajectories of neurobehavioral development during adolescence and young adulthood that relates to reinforcement-related psychopathology. In a recent study we identified a groups of adolescents who were chronically victimized by their peers across adolescence 49 . By age 19 these individuals had higher rates of anxiety, depression, and hyperactivity.…”

Section: Using Longitudinal Data To Develop Prediction and Developmenmentioning

confidence: 99%

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Identifying biological markers for improved precision medicine in psychiatry

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he is involved in clinical trials conducted by Eli Lilly, Novartis, and Shire and Viforpharma; he received royalities from Hogrefe, Kohlhammer, CIP Medien, Oxford University Press; the present work is unrelated to these relationships. Dr. Barker has received honoraria from General Electric Healthcare for teaching on scanner programming courses and acts as a consultant for IXICO. The other authors report no biomedical financial interests or potential conflicts of interest. Disclosures Dr. Banaschewski served in an advisory or consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH, Shire. He received conference support or speaker's fee by Lilly, Medice, Novartis and Shire. He has been involved in clinical trials conducted by Shire & Viforpharma. He received royalities from Hogrefe, Kohlhammer, CIP Medien, Oxford University Press. The present work is unrelated to the above grants and relationships. Dr. Barker has received honoraria from General Electric Healthcare for teaching on scanner programming courses and acts as a consultant for IXICO. The other authors report no biomedical financial interests or potential conflicts of interest.

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Section: Environmental Impact On Neural Mechanisms Of Mental Disordersmentioning

confidence: 93%

Section: Using Longitudinal Data To Develop Prediction and Developmenmentioning

confidence: 99%

Identifying biological markers for improved precision medicine in psychiatry

et al. 2019

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“…Because childhood victimization may affect brain development, and negative life events are associated with lasting changes in neuroticism, we hypothesized that childhood victimization may affect neuroticism via changes in brain development, and then neuroticism may act as a mediating factor between childhood victimization and depression in adulthood. 13,14 In this case-control study, we conducted a self-administered questionnaire-based investigation, assessing depressive symptoms, neuroticism, and the degree and frequency of victimization. This study used path analysis to investigate the effects of the experience of being victimized in childhood on depressive symptoms in healthy controls and patients with major depressive disorder (MDD), and the distinction between controls and MDD in adulthood.…”

Section: Introductionmentioning

confidence: 99%

<p>Victimization In Childhood Affects Depression In Adulthood Via Neuroticism: A Path Analysis Study</p>

Tachi

Asamizu

Uchida

et al. 2019

NDT

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Background: Adverse experiences, such as low care, overprotection, or abuse in childhood increase the likelihood of depression via their effects on personality traits. Similarly, being victimized in childhood may affect the likelihood of depression via personality traits. In this case-control study, we hypothesized that being victimized in childhood is associated with depression in adulthood via its effect on neuroticism, and verified this hypothesis using path analysis. Subjects and methods: Eighty-two major depressive disorder (MDD) patients and 350 age-and-sex matched healthy controls completed self-administered questionnaires of demographic data, Patient Health Questionnaire-9, neuroticism, and victimization. The association between victimization, neuroticism, and depressive symptoms or having major depression was investigated by path analysis. Results: Multiple group path analysis, in which depressive symptoms were considered as dependent variables, showed that the direct effect of victimization in childhood on depressive symptoms was not statistically significant in either healthy controls or MDD patients (standardized path coefficient: 0.079 and 0.084, respectively), but their indirect effects via neuroticism were statistically significant (standardized path coefficient: 0.059 and 0.141, respectively). Path analysis, in which the distinction between healthy controls and MDD patients was a dependent variable, showed that both direct effects and indirect effects of victimization in childhood via neuroticism on the distinction between healthy controls and MDD patients were statistically significant (standardized path coefficient: 0.186 and 0.164, respectively). Limitations: Recall bias and the relatively small number of MDD patients are limitations of this study. Because it was a case-control survey, this study could not make any conclusions regarding causal associations. Conclusion: This study suggests the possibility of causal associations between victimization in childhood and depressive symptoms or MDD in adulthood, and the mediation of this association by neuroticism.

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“…Further investigation involving more accurate data collection on this transaction between the school system and the parental system would definitely be helpful in the development of both intervention and prevention programs, as well as, further exploration of the protective and risk factors within each system that may influence the prevalence of bullying within educational settings. Those adolescents who have witnessed scenes of aggression at home frequently constitute a group at risk and recent brain-image studies show the impact of chronic peer-victimization at a neurological level for the adolescent's brain development (Quinlan et al, 2018). The characteristics of this population should be studied more depth in order to provide teachers, schools and other professionals with accurate and effective early detection and evidence-based intervention to deal and mitigate the harm that bullying can have as a traumatic experience in the school context and beyond.…”

Section: Discussionmentioning

confidence: 99%

Ecological-transaction model approach of adolescents’ parental maltreatment and peer-bullying: the moderating role of bullying at the classroom

Garcia¹,

Babarro

Toldos-Romero

2019

EJREP

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Introduction. The present study examined the ecological-transactional model delineated by Cicchetti and Lynch (1993) and the nature of the association between adolescents' parental maltreatment and victimization and bullying at school. Method.Multivariate multilevel regression analyses were conducted on a sample of 2.852 adolescents between the ages of 12 and 17 from 25 secondary schools. Data was nested across 133 classrooms. Classrooms level variables and individual variables in relationship to parental maltreatment, behavioural disorders, sex, and bullying and victimization were included in the analysis.Results. Results indicated that adolescents who reported suffering violence at home, showed more vulnerability to becoming victims of bullying at school, with the relationship being moderated by the level of bullying in the classroom. It was also examined the role of behavioural disorders and a relation between these factors was found amongst the bullies but not the victims. Discussion and Conclusion. This study uses the systemic perspective of ecological-transactional model on child maltreatment to show the importance between the school and home microsystems in the perpetuation of victimization. The results imply that what children experience at home might cause emotional and behavioural differences in varying classroom climates at school. Therefore, understanding the interactions between systems' transaction of socialisation mechanisms might contribute for effective anti-bullying programs. Ecological-transaction model approach of adolescents' parental maltreatment and peer-bullying: the moderating role of bullying at the classroom Resumen Introducción. Este estudio examina el modelo ecológico-transaccional propuesto por Cicchetti and Lynch (1993) y la naturaleza de la asociación entre adolescentes expuestos a maltrato parental y la victimización y bullying en la escuela. Método. Se realizó un análisis multivariado multinivel de regresión en una muestra de 2.852 adolescentes entre 12 y 17 años pertenecientes a 25 escuelas de secundaria. Los datos fueron anidados en 133 clases. Se utilizaron en el análisis, variables grupales relacionadas con el maltrato parental, trastornos comportamentales, género, victimización y abuso. Resultados. Los resultados indicaron que las víctimas de maltrato parental mostraban más vulnerabilidad para convertirse en víctimas de bullying, siendo esta relación moderada por el nivel de bullying en el aula. Además, se examinó el papel de los trastornos comportamentales encontrándose una relación significativa entre estos factores en los agresores. Discusión y Conclusión. Este estudio examina la perspectiva sistémica del modelo ecológicotransaccional sobre el maltrato infantil para demostrar la importancia entre los microsistemas escolares y familiares en la perpetuación de la victimización. Los resultados indican que lo que los niños experimentan en el hogar puede causar diferencias emocionales y comportamentales en función del clima del aula en la escuela. Por lo tanto, la comprensión...

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Peer victimization and its impact on adolescent brain development and psychopathology

Cited by 71 publications

References 67 publications

Identifying biological markers for improved precision medicine in psychiatry

Identifying biological markers for improved precision medicine in psychiatry

<p>Victimization In Childhood Affects Depression In Adulthood Via Neuroticism: A Path Analysis Study</p>

Ecological-transaction model approach of adolescents’ parental maltreatment and peer-bullying: the moderating role of bullying at the classroom

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