PEG-Based Hydrogel Coatings: Design Tools for Biomedical Applications

Wancura, Megan; Nkansah, Abbey; Robinson, Andrew; Toubbeh, Shireen; Talanker, Michael; Jones, S.; Cosgriff‐Hernandez, Elizabeth

doi:10.1007/s10439-023-03154-9

Cited by 6 publications

(3 citation statements)

References 65 publications

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“…A polyethylene glycol (PEG)-based hydrogel was selected given its established biocompatibility, soft tissue-like mechanical properties, and broad utility in biomedical applications. [19][20][21] In our previous study, we synthesized polyether urethane diacrylamide (PEUDAm), a more hydrolytically stable PEG macromer than poly(ethylene glycol) diacrylate (PEGDA). [22,23] Similar to PEGDA, PEUDAm is a neutral polymer; therefore, its conductivity depends solely on the ions in the aqueous phase.…”

Section: Introductionmentioning

confidence: 99%

Design of PEG-based hydrogels as soft ionic conductors

Rodriguez-Rivera,

Xu,

Laude

et al. 2024

Preprint

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Conductive hydrogels have gained interest in biomedical applications and soft electronics. To tackle the challenge of ionic hydrogels falling short of desired mechanical properties in previous studies, our investigation aimed to understand the pivotal structural factors that impact the conductivity and mechanical behavior of polyethylene glycol (PEG)-based hydrogels with ionic conductivity. Polyether urethane diacrylamide (PEUDAm), a functionalized long-chain macromer based on PEG, was used to synthesize hydrogels with ionic conductivity conferred by incorporating ions into the liquid phase of hydrogel. The impact of salt concentration, water content, temperature, and gel formation on both mechanical properties and conductivity was characterized to establish parameters for tuning hydrogel properties. To further expand the range of conductivity available in these ionic hydrogels, 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) was incorporated as a single copolymer network or double network configuration. As expected, conductivity in these ionic gels was primarily driven by ion diffusivity and charge density, which was dependent on hydrogel network formation and swelling. Copolymer network structure had minimal effect on the conductivity which was primarily driven by counter-ion equilibrium; however, the mechanical properties and equilibrium swelling was strongly dependent on network structure. The structure-property relationships elucidated here enables the rationale design of this new double network hydrogel to achieve target properties for a broad range of applications.

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Section: Introductionmentioning

confidence: 99%

Design of PEG-based hydrogels as soft ionic conductors

Rodriguez-Rivera,

Xu,

Laude

et al. 2024

Preprint

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“…Polyethylene glycol (PEG) is a common hydrophilic polymer acknowledged for its exceptional biocompatibility. [11] and is often recognized as the ''gold standard'' for antifouling polymers. It exerts a preventative effect against nonspecific protein adhesion by robust hydration interactions and steric repulsion effects.…”

Section: Introductionmentioning

confidence: 99%

Mechanical‐Enhanced and Durable Zwitterionic Hydrogel Coating for Inhibiting Coagulation and Reducing Bacterial Infection

Yan,

Yao,

Zhao

et al. 2024

Adv Healthcare Materials

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Blood‐contact medical devices are indispensable for clinical interventions, yet their susceptibility to thrombosis and bacterial infections poses substantial risks to treatment efficacy and patient well‐being. In this study, we introduce a polysulfobetaine/alginate‐CuII (SAC) zwitterionic hydrogel coating on polyurethane (PU) surfaces. This approach retained the superhydrophilic and antifouling nature of pSBMA while conferring the antibacterial effects of copper ions. Meanwhile, the copper alginate network intertwines with the polysulfobetaine (pSBMA) network, enhancing its mechanical properties and overcoming inherent weaknesses, thereby improving coating durability. Compared to the substrate, the SAC hydrogel coating significantly reduces thrombus adhesion mass by approximately 81.5% during extracorporeal blood circulation and effectively prevents bacterial biofilm formation even in a high‐concentration bacterial milieu over 30 days. Moreover, the results from an isolated blood circulation model in New Zealand white rabbits affirm the impressive anticoagulant efficacy of the SAC hydrogel coating. Our findings suggest that this hydrogel coating and its application method hold promise as a solution for blood‐contact material surface modification to address thrombosis and bacterial biofilm formation simultaneously.This article is protected by copyright. All rights reserved

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“…Acrylate-derivatized PEG (PEGDA) hydrogels are some of the most widely studied hydrogels; however, degradation of PEGDA hydrogels in vivo makes them unsuitable for long-term implantable applications. [1][2][3][4] Depending on the desired application, modifications can be made to PEG hydrogels to achieve specific outcomes such as biostability for hydrogel coatings [5][6][7][8] or controlled resorption profiles for wound healing 9,10 or stem cell delivery. 11,12 In order to successfully design hydrogels to meet application needs, researchers must understand the factors that contribute to degradation behavior and have rigorous methods to characterize degradation kinetics, as degradation can significantly impact performance and functionality.…”

Section: Introductionmentioning

confidence: 99%

A user's guide to degradation testing of polyethylene glycol‐based hydrogels: From in vitro to in vivo studies

Rodriguez‐Rivera,

Green,

Shah

et al. 2023

J Biomedical Materials Res

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Poly(ethylene glycol) (PEG)‐based hydrogels have gained significant attention in the field of biomedical applications due to their versatility and antifouling properties. Acrylate‐derivatized PEG hydrogels (PEGDA) are some of the most widely studied hydrogels; however, there has been debate around the degradation mechanism and predicting resorption rates. Several factors influence the degradation rate of PEG hydrogels, including backbone and endgroup chemistry, macromer molecular weight, and polymer concentration. In addition to hydrogel parameters, it is necessary to understand the influence of biological and environmental conditions (e.g., pH and temperature) on hydrogel degradation. Rigorous methods for monitoring degradation in both in vitro and in vivo settings are also critical to hydrogel design and development. Herein, we provide guidance on tailoring PEG hydrogel chemistry to achieve target hydrolytic degradation kinetics for both resorbable and biostable applications. A detailed overview of accelerated testing methods and hydrogel degradation characterization is provided to aid researchers in experimental design and interpreting in vitro–in vivo correlations necessary for predicting hydrogel device performance.

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PEG-Based Hydrogel Coatings: Design Tools for Biomedical Applications

Cited by 6 publications

References 65 publications

Design of PEG-based hydrogels as soft ionic conductors

Design of PEG-based hydrogels as soft ionic conductors

Mechanical‐Enhanced and Durable Zwitterionic Hydrogel Coating for Inhibiting Coagulation and Reducing Bacterial Infection

A user's guide to degradation testing of polyethylene glycol‐based hydrogels: From in vitro to in vivo studies

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