PEG‐based organic–inorganic hybrid coatings prepared by the sol–gel dip‐coating process for biomedical applications

Abstract

In the present work, the application of functional coatings on metallic implants was proposed to delay implant failure by improving tissue tolerance and implant osseointegration. Three bioactive and biocompatible organic–inorganic hybrid nanocomposites, consisting of polyethylene glycol (PEG) embedded in a SiO2, ZrO2, and TiO2 matrix, respectively, were synthesized via the sol–gel method. Materials in the sol phase were used to dip‐coat titanium grade 4 substrates for use as dental and orthopedic implant models. To investigate the influence of the glass matrix and the polymer amount on the coating structure, and thus on their biological properties, several hybrids were obtained by adding different weight percentages of PEG to each glass matrix. Attenuated total reflectance Fourier transform infrared spectroscopy confirmed the presence of the polymer in the nanocomposites and scanning electron microscopy showed that an increase in the PEG content allows crack‐free coatings to be obtained. Moreover, the bioactivity and biocompatibility of both the uncoated and coated titanium implants were investigated and compared by an in vitro test. The results revealed that coated substrates have more enhanced biological performance than the uncoated ones. The bioactivity is not significantly affected by either the inorganic matrix or the PEG amount, whereas the presence of polymer makes the films more biocompatible. POLYM. ENG. SCI., 57:478–484, 2017. © 2017 Society of Plastics Engineers

Long‐range dipole–dipole energy transfer enhancement via addition of SiO2/TiO2 nanocomposite in PFO/MEH‐PPV hybrid thin films

“…Several strategies have been developed to prepare well‐defined inorganic/organic hybrid NCs. The most common of these strategies are via starlike polymer as nanoreactors, sol–gel, in situ polymerization, and solution blending method . In this study, poly (9,9 ′ ‐di‐n‐octylfluorenyl‐2.7‐diyl) (PFO) as a donor and poly [2‐methoxy‐5‐(2‐ethyl‐hexyloxy)‐1,4‐phenylenevinylene] (MEH‐PPV) as an acceptor were blended at various ratios with and without a SiO 2 /TiO 2 NC by the solution blending method.…”

Sol–gel bioglasses in dental and periodontal regeneration: A systematic review

“…Among the 52 papers, 11 have studied pure BGs, 23 have assessed doped‐glasses, and 18 have used composite materials …”

“…Six additional papers have studied the effects of different combined materials on other cell types. Coating Ti disks with a Si–Ca/PCL6 scaffold or combining BGs with forsterite or leuciteenhanced the proliferation of NIH3T3, human osteoblast‐like cells and rat derived osteoblasts respectively.…”

“…Coating Ti disks with a Si–Ca/PCL6 scaffold or combining BGs with forsterite or leuciteenhanced the proliferation of NIH3T3, human osteoblast‐like cells and rat derived osteoblasts respectively. As well mixing glasses with CHT/PEG (polyethylene glycol) ratio, calcium phosphate or PEG (0, 6, 12, 24, and 50 wt%) dip‐coat Ti4 promoted proliferation and cell differentiation of human fibroblasts, NIH 3T3 and C3H10T1/2 in a concentration and time‐dependent manner.…”

Tuning Photophysical Properties of Donor/Acceptor Hybrid Thin- Film via Addition of SiO2/TiO2 Nanocomposites

“…Numerous approaches, such as solution blending method [ 2 ], sol –gel [ 11 ], in situ polymerization [ 12 ], and star-like polymer as nanoreactors [ 13 ], have been established to prepare well-defined organic/inorganic nanocomposites. In the recent studies, the effect of fixed ratio of individual TiO 2 or SiO 2 NPs and fixed STNCs on the energy transfer of the various blend ratios of poly [2methoxy-5-(2-ethyl-hexyloxy)-1,4-phenylenevinylene] (MEH-PPV) and poly (9,9′-di-n-octylfluorenyl-2.7-diyl) (PFO) was investigated in details [ 7 ].…”