PEG-functionalized iron oxide nanoclusters loaded with chlorin e6 for targeted, NIR light induced, photodynamic therapy

Li, Zhiwei; Wang, Chao; Cheng, Liang; Gong, Hua; Yin, Shengnan; Gong, Qiufang; Li, Yonggang; Liu, Zhuang

doi:10.1016/j.biomaterials.2013.08.041

Cited by 186 publications

(137 citation statements)

References 40 publications

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“…16 Notably, the maximum loading efficiency can reach to ~57 wt%, which is much higher than those previously reports where Ce6 was loaded through either encapsulation or π-π interaction ( Table 1). 14,16,54,[66][67][68][69] This is further confirmed by MALDI-TOF MS (Fig. S4 ).…”

Section: Resultssupporting

confidence: 78%

Fullerene/photosensitizer nanovesicles as highly efficient and clearable phototheranostics with enhanced tumor accumulation for cancer therapy

Guan

et al. 2016

Biomaterials

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A novel phototheranostic platform based on tri-malonate derivative of fullerene C70 (TFC70)/photosensitizer (Chlorin e6, Ce6) nanovesicles (FCNVs) has been developed for effective tumor imaging and treatment. The FCNVs were prepared from amphiphilic TFC70-oligo ethylene glycol -Ce6 molecules. The developed FCNVs possessed the following advantages: (i) high loading efficiency of Ce6 (up to ∼57 wt%); (ii) efficient absorption in near-infrared light region; (iii) enhanced cellular uptake efficiency of Ce6 in vitro and in vivo; (iv) good biocompatibility and total clearance out from the body. These unique properties suggest that the as-prepared FCNVs could be applied as an ideal theranostic agent for simultaneous imaging and photodynamic therapy of tumor. This finding may provide a good solution to highly efficient phototheranostic applications based on fullerene derivatives fabricated nanostructures.

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Section: Resultssupporting

confidence: 78%

Fullerene/photosensitizer nanovesicles as highly efficient and clearable phototheranostics with enhanced tumor accumulation for cancer therapy

Guan

et al. 2016

Biomaterials

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“…[1][2][3][4] In recent years, PDT has achieved rapid progress both in fundamental research [5][6][7][8] and clinic practice, [9][10][11] which makes it become the fourth minimal invasive therapy for cancer treatment following surgery, radiotherapy and chemotherapy. 12 PDT is based on the principle that light-activated photosensitizer can produce lethal cytotoxic active singlet oxygen ( 1 O 2 ) and other reactive oxygen species (ROS) to damage tumors and their surrounding vasculature when the tumor tissues uptaking the photosensitizer are irradiated with a specific wavelength light in the presence of tissue oxygen.…”

Section: Introductionmentioning

confidence: 99%

Magnetic and pH dual-responsive mesoporous silica nanocomposites for effective and low-toxic photodynamic therapy

Zhan¹,

Ma²,

Wang³

et al. 2017

IJN

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Nonspecific targeting, large doses and phototoxicity severely hamper the clinical effect of photodynamic therapy (PDT). In this work, superparamagnetic Fe 3 O 4 mesoporous silica nanoparticles grafted by pH-responsive block polymer polyethylene glycol- b -poly(aspartic acid) (PEG- b -PAsp) were fabricated to load the model photosensitizer rose bengal (RB) in the aim of enhancing the efficiency of PDT. Compared to free RB, the nanocomposites (polyethylene glycol- b -polyaspartate-modified rose bengal-loaded magnetic mesoporous silica [RB−MMSNs]) could greatly enhance the cellular uptake due to their effective endocytosis by mouse melanoma B16 cell and exhibited higher induced apoptosis although with little dark toxicity. RB−MMSNs had little dark toxicity and even much could be facilitated by magnetic field in vitro. RB−MMSNs demonstrated 10 times induced apoptosis efficiency than that of free RB at the same RB concentration, both by cell counting kit-8 (CCK-8) result and apoptosis detection. Furthermore, RB−MMSNs-mediated PDT in vivo on tumor-bearing mice showed steady physical targeting of RB−MMSNs to the tumor site; tumor volumes were significantly reduced in the magnetic field with green light irradiation. More importantly, the survival time of tumor-bearing mice treated with RB−MMSNs was much prolonged. Henceforth, polyethylene glycol- b -polyaspartate-modified magnetic mesoporous silica (MMSNs) probably have great potential in clinical cancer photodynamic treatment because of their effective and low-toxic performance as photosensitizers’ vesicles.

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“…3a) shows a strong peak at 580 cm -1 , which corresponds to the vibration of Fe-O [21]. In the 3435 cm -1 frequency region, the increased broad peak associates with the stretching vibration bands of -OH groups [18]. The bands at 2923 and 2840 cm -1 are assigned to the stretching C-H vibrations of alkyl, and the band at 1623 cm -1 is assigned to the stretching N-H vibrations [14].…”

Section: Characterizationmentioning

confidence: 95%

“…For a delivery system to be effective, the drug loading efficiency is critical. Many studies on modification or coating of magnetic nanoparticles with mesoporous silica have potential applications in biomedical fields [18]. For example, Peng et al [19] prepared (b-CD)-functionalized Fe 3 O 4 @ZnO nanoparticles for drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Fe3O4@ZnS@Glycine nanoparticle as a novel microwave stimulus controlled drug release system

Peng

et al. 2016

J Sol-Gel Sci Technol

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The stimuli-responsive controlled drug delivery system is highly desirable for an efficient cancer treatment approach. Herein, we have successfully developed a novel multifunctional microwave stimulus controlled anticancer drug release system based on magnetic Fe 3 O 4 @-ZnS@Glycine nanoparticles. Fe 3 O 4 core has a high magnetization saturation value for drug targeting under foreign magnetic fields. ZnS shells can efficiently convert microwave energy into thermal energy for microwave-triggered drug release. The glycine-modified layer of nanoparticles provides active group (-NH 2 ) for the loading of drug molecules by hydrogen bond. The in vitro studies have clearly demonstrated the feasibility and advantage of the novel nanocarriers for remote-controlled drug release systems.Graphical Abstract We combined the advantages of ZnS nanoparticles with those of Fe 3 O 4 and glycine to create a new drug delivery system, which is capable of carrying drug molecules and triggered release of the drug by microwave treatment.

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PEG-functionalized iron oxide nanoclusters loaded with chlorin e6 for targeted, NIR light induced, photodynamic therapy

Cited by 186 publications

References 40 publications

Fullerene/photosensitizer nanovesicles as highly efficient and clearable phototheranostics with enhanced tumor accumulation for cancer therapy

Fullerene/photosensitizer nanovesicles as highly efficient and clearable phototheranostics with enhanced tumor accumulation for cancer therapy

Magnetic and pH dual-responsive mesoporous silica nanocomposites for effective and low-toxic photodynamic therapy

Fe3O4@ZnS@Glycine nanoparticle as a novel microwave stimulus controlled drug release system

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