PEG functionalized zirconium dicarboxylate MOFs for docetaxel drug delivery in vitro

Metal-organic frameworks for virus detection

“…The π-π stacks generated between the aromatic structure of Dpphen or Phen ligand and nucleobases, as well as the anionic DNA backbone to form an electrostatic attraction with the positively charged ligands (NMe 3+ ) and metals ions (In 3+ ) ( Li et al, 2016 ). Other ionized MOFs including the carboxyl-rich MOF-n family ( Yaghi et al, 1995 ), IRMOF-n family ( Eddaoudi et al, 2002 ), MIL-n family ( Dan Hardi et al, 2009 ; Naeimi and Faghihian, 2019 ), UiO-n ( Cavka et al, 2008 ; Gupta et al, 2019 ), DUT-n ( Abazari et al, 2018 ; Grunker et al, 2014 ), and imidazole-rich ZIF-n family ( Park et al, 2006 ; Sheno et al, 2019 ; Zhao et al, 2019b ), or functional groups in the ligand, such as pyridine group (-C 5 H 4 N) ( Lago et al, 2016 ), imidazolyl (-C 3 H 3 N 2 ) ( Zhao et al, 2019b ), carboxyl group (-COOH) ( Adhikari et al, 2018 ), daunosamine and amino group (-NH 2 ) ( Nezhad-Mokhtari et al, 2019 ; Xue et al, 2019 ), phenolic hydroxyl group ( Ke et al, 2019 ), might also have great potential to be adopted as a source of electrostatic interaction for nucleic acid detection owing to the protonated ligand and the charge reverses in an acidic environment. Besides, designing charged MOF is an excellent idea ( Zhao et al, 2019c ) in addition to introducing functional groups ( Ali Akbar Razavi and Morsali, 2019 ).…”

Advances in antitumor nanomedicine based on functional metal–organic frameworks beyond drug carriers

“…For example, Vandana Gupta et al synthesized the UiO-66 MOF by a solvothermal method. 107 UiO-66 is composed of Zr metal ions and the organic ligand 1,4-benzenedicarboxylate. Docetaxel (DTX) was covalently linked to the amine functional group on the surface of UiO-66 to give DTX@UiO-66 (Fig.…”

Machine Learning Meets with Metal Organic Frameworks for Gas Storage and Separation

“…MOFs have been studied for many different areas such as gas storage and separation, 7 − 10 bioimaging, 11 catalysis, 12 , 13 batteries, 14 supercapacitors, 15 and drug delivery. 16 Currently, there are 103 951 experimentally synthesized MOFs deposited into the Cambridge Structural Database (CSD), 17 and this number is continuously increasing due to the existence of theoretically infinite number of possible MOF structures. This very large number of MOFs is a great advantage for the potential applications of materials but, on the other hand, it is not practical to experimentally test the performances of all these MOFs even for a single application at the lab scale.…”

“…The large number of possible metal nodes and organic ligand variations for synthesis of MOFs leads to attractive physical and chemical features such as high thermal stabilities (as high as 500 °C), various porosities (0.3–0.9), large surface areas (>8000 m 2 g –1 ), low densities (0.2 g cm –3 ), and wide range of pore sizes (3–100 Å). , The ability to tune physical and chemical properties of MOFs during or after synthesis by metal cation exchange, attachment or insertion of functional groups, , allowed the researchers to generate various types of MOFs with desired properties for a specific application. MOFs have been studied for many different areas such as gas storage and separation, − bioimaging, catalysis, , batteries, supercapacitors, and drug delivery . Currently, there are 103 951 experimentally synthesized MOFs deposited into the Cambridge Structural Database (CSD), and this number is continuously increasing due to the existence of theoretically infinite number of possible MOF structures.…”