PEG–PEI-modified gated N-doped mesoporous carbon nanospheres for pH/NIR light-triggered drug release and cancer phototherapy

Panda, Snigdharani; Bhol, Chandra Sekhar; Bhutia, Sujit K.; Mohapatra, Sasmita

doi:10.1039/d1tb00362c

Cited by 16 publications

(14 citation statements)

References 39 publications

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“…By contrast, neutral pH restricts the uncoiling of DSPE-PEG; therefore, least percentage of the drug is unleashed even after a long incubation time. Furthermore, the thermosensitiveness of the PEGylated polymer innovatively worked as a gatekeeper, which was stimulated under laser irradiation for controlled drug release. , Figure b shows that momentary (10 min) illumination of NIR light suddenly enhances the drug release rate; removal of NIR light again shows steady-state release. We performed laser exposure at 6, 10, 20, 30, 40, and 50 h time points, and such NIR-induced increment should have originated from NMC that can efficiently convert NIR light into heat, followed by melting of the PEGylated unit.…”

Section: Resultsmentioning

confidence: 99%

DSPE-PEG-Coated Uniform Nitrogen-Doped Carbon Capsules for NIR-Mediated Synergistic Chemophototherapy of Skin Cancer

Panda

Bhol

Bhutia

et al. 2021

ACS Appl. Bio Mater.

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Uniform monodispersed nitrogen-doped carbon spheres have been emerging as an exciting platform for multipurpose medical applications like photothermal therapy and photoacoustic imaging and as carriers for aromatic anticancer drugs. However, synthesis of uniform N-doped mesoporous carbon of size less than 100 nm with reasonable photothermal and photodynamic activities is a challenging task. In this connection, the present paper reports synthesis of nitrogen-doped mesoporous carbon spheres (NMCSs) from five different copolymers of pyrrole and substituted aniline (-H, o-NH2, m-NH2, p-NH2, and m-NO2) using a soft template approach. It has been found that NMCSs synthesized from poly(pyrrole-co-m-nitroaniline) show uniform mesoporous particles of size 80 nm, a photothermal conversion efficiency η of 52.7%, and an average 1O2 quantum yield of 20% under exposure of a 980 nm NIR laser. With a high η of 52%, a multifunctional nanodrug has been formulated by loading 5-Fu in NMCS. The overall drug-loaded NMC was encapsulated by thermosensitive DSPE-PEG to improve translocation of the particle in the cell and thermosensitive drug release. A reliable release of anticancer drug 5-Fu (78%) has been achieved in 50 h in lysosomal conditions under 980 nm laser exposure. This NMC-5-Fu-DSPE-PEG nanodrug produces reactive oxygen species and enhances the therapeutic effect in comparison with free drug under an NIR laser as verified in B16F0 melanoma cells.

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Section: Resultsmentioning

confidence: 99%

DSPE-PEG-Coated Uniform Nitrogen-Doped Carbon Capsules for NIR-Mediated Synergistic Chemophototherapy of Skin Cancer

Panda

Bhol

Bhutia

et al. 2021

ACS Appl. Bio Mater.

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“…Light-responsive: photo-cleavable-o-nitrobenzyl, with a linker of thermosensitive: PEG-PEI. [123] PEO-PEtG-PEO Poly(ethyl glyoxylate)-Poly(ethylene oxide)…”

Section: Combination Of Various Stimuli For Polymersmentioning

confidence: 99%

“…There has been a trend in recent years to incorporate the potential for many stimuli to trigger the drug release by a carrier to a specific disease site [90,106,107,109,123,124]. Lei et al used mesoporous silica as the nanocarrier for doxorubicin and coated th particles with polydopamine [108].…”

Section: Multiple-stimuli-responsive Polymersmentioning

confidence: 99%

Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug Delivery

2022

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Polymers that can change their properties in response to an external or internal stimulus have become an interesting platform for drug delivery systems. Polymeric nanoparticles can be used to decrease the toxicity of drugs, improve the circulation of hydrophobic drugs, and increase a drug’s efficacy. Furthermore, polymers that are sensitive to specific stimuli can be used to achieve controlled release of drugs into specific areas of the body. This review discusses the different stimuli that can be used for controlled drug delivery based on internal and external stimuli. Internal stimuli have been defined as events that evoke changes in different characteristics, inside the body, such as changes in pH, redox potential, and temperature. External stimuli have been defined as the use of an external source such as light and ultrasound to implement such changes. Special attention has been paid to the particular chemical structures that need to be incorporated into polymers to achieve the desired stimuli response. A current trend in this field is the incorporation of several stimuli in a single polymer to achieve higher specificity. Therefore, to access the most recent advances in stimuli-responsive polymers, the focus of this review is to combine several stimuli. The combination of different stimuli is discussed along with the chemical structures that can produce it.

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“…Nanophosphors are excited by light in the near-infrared range, which can penetrate biological tissue to a depth of several centimeters. The luminescence spectrum of upconverting nanoparticles has intense bands in the visible and UV regions, nanoparticles can transfer energy to photosensitizers without emission, and they have high photostability [10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

New Cysteine-Containing PEG-Glycerolipid Increases the Bloodstream Circulation Time of Upconverting Nanoparticles

et al. 2022

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Upconverting nanoparticles have unique spectral and photophysical properties that make them suitable for development of theranostics for imaging and treating large and deep-seated tumors. Nanoparticles based on NaYF4 crystals doped with lanthanides Yb3+ and Er3+ were obtained by the high-temperature decomposition of trifluoroacetates in oleic acid and 1-octadecene. Such particles have pronounced hydrophobic properties. Therefore, to obtain stable dispersions in aqueous media for the study of their properties in vivo and in vitro, the polyethylene glycol (PEG)-glycerolipids of various structures were obtained. To increase the circulation time of PEG-lipid coated nanoparticles in the bloodstream, long-chain substituents are needed to be attached to the glycerol backbone using ether bonds. To prevent nanoparticle aggregation, an L-cysteine-derived negatively charged carboxy group should be included in the lipid molecule.

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PEG–PEI-modified gated N-doped mesoporous carbon nanospheres for pH/NIR light-triggered drug release and cancer phototherapy

Abstract: A novel hybrid drug carrier has been designed taking N- doped mesoporous carbon (NMCS) as the core and PEG-PEI as outer shell. NMCS is functionalized with photocleavable nitrobenzyl based linker...

Cited by 16 publications

References 39 publications

DSPE-PEG-Coated Uniform Nitrogen-Doped Carbon Capsules for NIR-Mediated Synergistic Chemophototherapy of Skin Cancer

DSPE-PEG-Coated Uniform Nitrogen-Doped Carbon Capsules for NIR-Mediated Synergistic Chemophototherapy of Skin Cancer

Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug Delivery

New Cysteine-Containing PEG-Glycerolipid Increases the Bloodstream Circulation Time of Upconverting Nanoparticles

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