PEG-SH-GNPs-SAPNS@miR-29a delivery system promotes neural regeneration and recovery of motor function after spinal cord injury

Wan, Junming; Liu, Hanzhong; Li, Jiachun; Zeng, Yuqing; Hu, Yougen

doi:10.1080/09205063.2023.2230841

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…Spinal cord injury (SCI) can be caused by inflammation, which hinders its functional recovery. Wan et al 176 designed the gold nanoparticles and self-assembling peptide hydrogel composite scaffold (PEG-SH-GNPs-SAPNS @ miR-29a delivery system) to repair damaged spinal cord by constructing a regenerative microenvironment for recruiting endogenous neural stem cells ( Figure 13 ). Sulfhydryl polyethylene glycol (PEG-SH) is utilized to enhance the biocompatibility and stability of gold nanoparticles (GNPs), enabling them to more effectively penetrate and function within damaged spinal cord tissue.…”

Section: Role and Mechanism Of Mirna Hydrogel Delivery System In Infl...mentioning

confidence: 99%

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Mechanisms of hydrogel-based microRNA delivery systems and its application strategies in targeting inflammatory diseases

Hu,

Liang,

Chen

et al. 2024

J Tissue Eng

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Hydrogels, composed of three-dimensional polymer networks, are excellent delivery carriers and have been extensively employed in the biomedical field. Inflammation acts as a protective mechanism to prevent harmful substances from entering living organisms, but chronic, long-lasting inflammation can cause oxidative stress, which damages tissue and organs and adversely affects patients’ quality of life. The aberrant expression of microRNAs (miRNAs) has been found to play a significant part in the etiology and progression of inflammatory diseases, as suggested by growing evidence. Numerous hydrogels that can act as gene carriers for the intracellular delivery of miRNA have been described during ongoing research into innovative hydrogel materials. MiRNA hydrogel delivery systems, which are loaded with exogenous miRNA inhibitors or mimics, enable targeted miRNA intervention in inflammatory diseases and effectively prevent environmental stressors from degrading or inactivating miRNA. In this review, we summarize the classification of miRNA hydrogel delivery systems, the basic strategies and mechanisms for loading miRNAs into hydrogels, highlight the biomedical applications of miRNA hydrogel delivery systems in inflammatory diseases, and share our viewpoints on potential opportunities and challenges in the promising region of miRNA delivery systems. These findings may provide a new theoretical basis for the prevention and treatment of inflammation-related diseases and lay the foundation for clinical translation.

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Section: Role and Mechanism Of Mirna Hydrogel Delivery System In Infl...mentioning

confidence: 99%

Section: Role and Mechanism Of Mirna Hydrogel Delivery System In Infl...mentioning

confidence: 99%

Mechanisms of hydrogel-based microRNA delivery systems and its application strategies in targeting inflammatory diseases

Hu,

Liang,

Chen

et al. 2024

J Tissue Eng

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Hydrogel and Nanomedicine‐Based Multimodal Therapeutic Strategies for Spinal Cord Injury

Yin,

Liang,

Han

et al. 2023

Small Methods

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Spinal cord injury (SCI) is a severe neurodegenerative disease caused by mechanical and biological factors, manifesting as a loss of motor and sensory functions. Inhibition of injury expansion and even reversal of injury in the acute damage stage of SCI are important strategies for treating this disease. Hydrogels and nanoparticle (NP)‐based drugs are the most effective, widely studied, and clinically valuable therapeutic strategies in the field of repair and regeneration. Hydrogels are 3D flow structures that fill the pathological gaps in SCI and provide a microenvironment similar to that of the spinal cord extracellular matrix for nerve cell regeneration. NP‐based drugs can easily penetrate the blood‐spinal cord barrier, target SCI lesions, and are noninvasive. Hydrogels and NPs as drug carriers can be loaded with various drugs and biological therapeutic factors for slow release in SCI lesions. They help drugs function more efficiently by exerting anti‐inflammatory, antioxidant, and nerve regeneration effects to promote the recovery of neurological function. In this review, the use of hydrogels and NPs as drug carriers and the role of both in the repair of SCI are discussed to provide a multimodal strategic reference for nerve repair and regeneration after SCI.

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Current advances in the development of microRNA-integrated tissue engineering strategies: a cornerstone of regenerative medicine

Castañón-Cortés,

Bravo-Vázquez,

Santoyo-Valencia

et al. 2024

Front. Bioeng. Biotechnol.

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Regenerative medicine is an innovative scientific field focused on repairing, replacing, or regenerating damaged tissues and organs to restore their normal functions. A central aspect of this research arena relies on the use of tissue-engineered scaffolds, which serve as structural supports that mimic the extracellular matrix, providing an environment that orchestrates cell growth and tissue formation. Remarkably, the therapeutic efficacy of these scaffolds can be improved by harnessing the properties of other molecules or compounds that have crucial roles in healing and regeneration pathways, such as phytochemicals, enzymes, transcription factors, and non-coding RNAs (ncRNAs). In particular, microRNAs (miRNAs) are a class of tiny (20–24 nt), highly conserved ncRNAs that play a critical role in the regulation of gene expression at the post-transcriptional level. Accordingly, miRNAs are involved in a myriad of biological processes, including cell differentiation, proliferation, and apoptosis, as well as tissue regeneration, angiogenesis, and osteogenesis. On this basis, over the past years, a number of research studies have demonstrated that miRNAs can be integrated into tissue-engineered scaffolds to create advanced therapeutic platforms that precisely modulate cellular behavior and offer a controlled and targeted release of miRNAs to optimize tissue repair and regeneration. Therefore, in this current review, we discuss the most recent advances in the development of miRNA-loaded tissue-engineered scaffolds and provide an overview of the future outlooks that should be aborded in this area of study in order to lay the groundwork for the clinical translation of these tissue engineering approaches.

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PEG-SH-GNPs-SAPNS@miR-29a delivery system promotes neural regeneration and recovery of motor function after spinal cord injury

Cited by 3 publications

References 37 publications

Mechanisms of hydrogel-based microRNA delivery systems and its application strategies in targeting inflammatory diseases

Mechanisms of hydrogel-based microRNA delivery systems and its application strategies in targeting inflammatory diseases

Hydrogel and Nanomedicine‐Based Multimodal Therapeutic Strategies for Spinal Cord Injury

Current advances in the development of microRNA-integrated tissue engineering strategies: a cornerstone of regenerative medicine

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