Pegmolesatide for the treatment of anemia in patients undergoing dialysis: a randomized clinical trial

Zhang, Ping; Jiang, Yan; Xu, Chunping; Zhou, Linghui; Zheng, Hongguang; Xie, Deqiong; Guo, Minghao; Huang, Xiangyang; Lu, Guoyuan; Jiang, Hongli; Qiu, Hongyu; Liu, Bicheng; Li, Shaomei; Chen, Qinkai; Xia, Yu'ou; Sun, Bengui; Yang, Xiao; Zhang, Shiying; Du, Shutong; Sun, Mindan; Chen, Menghua; Zhong, Aimin; Wang, Xiaoling; Zhao, Zhanzheng; Zhou, Hua; Li, Guisen; Ren, Yueqin; Luo, Qun; Yang, Aicheng; Luo, Ping; Tang, Shuifu; Xu, Chengyun; Wang, Qin; Wang, Xiaoxia; Yan, Tiekun; He, Wei; Qin, Shuguang; Zhang, Weili; Lv, Lu; Wang, Cheng; Liu, Hong; Li, Jing; Wu, Qiong; Pan, Chao; Li, Chuan; He, Liangliang; Chen, Jianghua

doi:10.1016/j.eclinm.2023.102273

eClinicalMedicine

2023

DOI: 10.1016/j.eclinm.2023.102273

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Pegmolesatide for the treatment of anemia in patients undergoing dialysis: a randomized clinical trial

Ping Zhang,

Yan Jiang,

Chunping Xu

et al.

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2024

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Cited by 3 publications

References 21 publications

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Randomized Trial of Pegmolesatide for the Treatment of Anemia in Patients With Nondialysis CKD

Xie,

Yang,

Qiu

et al. 2024

Kidney International Reports

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Randomized Trial of Pegmolesatide for the Treatment of Anemia in Patients With Nondialysis CKD

Xie,

Yang,

Qiu

et al. 2024

Kidney International Reports

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Modeling and biological evaluation of pegmolesatide, a novel and potent erythropoiesis-stimulating agent

Zhou,

Lang,

Yang

et al. 2024

Journal of Asian Natural Products Research

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Iron biology

Del Vecchio,

Girelli,

Vinchi

et al. 2024

Nephrology Dialysis Transplantation

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Iron is a fundamental element for biological life, starting from bacteria till humans. Iron is essential for cell function and survival, energy production and metabolism, whereas increased levels cause oxidative stress. It is also a constituent of haemoglobin and thus it is necessary for oxygen transportation through the body. Given these multiple functions, the regulation of iron metabolism is complex and tight coupled with oxygen homeostasis at tissue and cellular levels, thanks to the interaction with the hypoxia inducible factor (HIF) system. In patients with chronic kidney disease (CKD), iron deficiency significantly contributes to anaemia development. This frequently overlaps with chronic inflammation, causing iron- restricted erythropoiesis. To add further complexity, metabolic hyperferritinemia may, on one side, increase the risk for CKD and, on the other, overlaps with functional iron deficiency. Excessive intracellular iron in certain cell types during CKD can also mediate cellular death (called ferroptosis), and contribute to the pathogenesis of kidney damage, atherosclerosis and vascular calcifications. This review is aimed at broadening the perspective of iron metabolism in the setting of CKD not just as a contributor to anaemia in CKD patients, but also as an important player with an impact on cell metabolism, renal fibrosis, and the cardiovascular system.

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Pegmolesatide for the treatment of anemia in patients undergoing dialysis: a randomized clinical trial

Cited by 3 publications

References 21 publications

Randomized Trial of Pegmolesatide for the Treatment of Anemia in Patients With Nondialysis CKD

Randomized Trial of Pegmolesatide for the Treatment of Anemia in Patients With Nondialysis CKD

Modeling and biological evaluation of pegmolesatide, a novel and potent erythropoiesis-stimulating agent

Iron biology

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