PEGylated chitosan-coated nanophotosensitizers for effective cancer treatment by photothermal-photodynamic therapy combined with glutathione depletion

Chen, Yu-Hsin; Liu, I-Ju; Lin, Tzu-Chen; Tsai, Min-Chen; Hu, Shang-Hsiu; Hsu, Tsai-Ching; Wu, Yi-Ting; Tzang, Bor-Show; Chiang, Wen-Hsuan

doi:10.1016/j.ijbiomac.2024.131359

Cited by 7 publications

(1 citation statement)

References 65 publications

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“…The disruption of the lipid bilayer composition in cells can be attributed to the amphiphilic nature of mPEG- b -C18 and its capacity to interact with lipid molecules. The hydrophilic mPEG (polyethylene glycol) block tends to interact with water molecules, while the hydrophobic C18 (octadecyl) block prefers to interact with the hydrophobic tails of lipid molecules within the bilayer. , This amphiphilic behavior allows mPEG- b -C18 to insert itself into the lipid bilayer, leading to disruption of the bilayer’s organization and stability. Consequently, this disruption compromises the integrity of the lipid bilayer, impacting essential cellular processes, including membrane permeability, signaling, and cell–cell interactions.…”

Section: Resultsmentioning

confidence: 99%

A Self-Cascade Penetrating Brain Tumor Immunotherapy Mediated by Near-Infrared II Cell Membrane-Disrupting Nanoflakes via Detained Dendritic Cells

Yalamandala,

Chen,

Lin

et al. 2024

ACS Nano

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Immunotherapy can potentially suppress the highly aggressive glioblastoma (GBM) by promoting T lymphocyte infiltration. Nevertheless, the immune privilege phenomenon, coupled with the generally low immunogenicity of vaccines, frequently hampers the presence of lymphocytes within brain tumors, particularly in brain tumors. In this study, the membrane-disrupted polymer-wrapped CuS nanoflakes that can penetrate delivery to deep brain tumors via releasing the cell−cell interactions, facilitating the near-infrared II (NIR II) photothermal therapy, and detaining dendritic cells for a self-cascading immunotherapy are developed. By convection-enhanced delivery, membrane-disrupted amphiphilic polymer micelles (poly(methoxypoly(ethylene glycol)-benzoic imineoctadecane, mPEG-b-C18) with CuS nanoflakes enhances tumor permeability and resides in deep brain tumors. Under low-power NIR II irradiation (0.8 W/cm 2 ), the intense heat generated by well-distributed CuS nanoflakes actuates the thermolytic efficacy, facilitating cell apoptosis and the subsequent antigen release. Then, the positively charged polymer after hydrolysis of the benzoic-imine bond serves as an antigen depot, detaining autologous tumorassociated antigens and presenting them to dendritic cells, ensuring sustained immune stimulation. This selfcascading penetrative immunotherapy amplifies the immune response to postoperative brain tumors but also enhances survival outcomes through effective brain immunotherapy.

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Section: Resultsmentioning

confidence: 99%

A Self-Cascade Penetrating Brain Tumor Immunotherapy Mediated by Near-Infrared II Cell Membrane-Disrupting Nanoflakes via Detained Dendritic Cells

Yalamandala,

Chen,

Lin

et al. 2024

ACS Nano

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Reprogrammed Lung Metastasis Immunodeficiency via Targeted Penetrated Delivery of M1 Macrophage‐Wrapped NanoCubes‐Mediated T Cell Infiltration

Wang,

Li,

Huang

et al. 2024

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The infiltration of cytotoxic T lymphocytes holds promise for suppressing even the most resilient metastatic tumors in immunotherapy. Polarizing tumor‐associated macrophages (TAMs) and remodeling the immune‐deficient tumor microenvironment (TME) can enhance T lymphocyte recruitment and infiltration. However, the immune privilege and low immunogenic responses of these aggressive tumor clusters often limit lymphocyte recruitment. Here, an M1 macrophage membrane‐coated iron oxide nanoparticle (IO@MM) double as a tumor‐penetrated agent and naïve M0 macrophage to M1 polarizer is developed for lung metastatic colorectal cancer (CRC) immunotherapy. At the tumor site, IO@MM combined with resiquimod (R848) increased the immune cell infiltration, turning the “Cold” TME into an immune‐activating “Hot” one. Together with self‐cascade immunotherapy, IO@MM with R848 promotes tumor release of damage‐associated molecular patterns (DAMPs). At the same time, IO@MM uses the membrane as an antigen reservoir and provides autologous DAMPs to retain dendritic cells. This IO@MM effectively inhibits tumors and improves survival rate as an immunomodulator in lung metastasis.

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The dual role of photodynamic therapy to treat cancer and microbial infection

Akhtar,

Misba,

Khan

2024

Drug Discovery Today

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PEGylated chitosan-coated nanophotosensitizers for effective cancer treatment by photothermal-photodynamic therapy combined with glutathione depletion

Cited by 7 publications

References 65 publications

A Self-Cascade Penetrating Brain Tumor Immunotherapy Mediated by Near-Infrared II Cell Membrane-Disrupting Nanoflakes via Detained Dendritic Cells

A Self-Cascade Penetrating Brain Tumor Immunotherapy Mediated by Near-Infrared II Cell Membrane-Disrupting Nanoflakes via Detained Dendritic Cells

Reprogrammed Lung Metastasis Immunodeficiency via Targeted Penetrated Delivery of M1 Macrophage‐Wrapped NanoCubes‐Mediated T Cell Infiltration

The dual role of photodynamic therapy to treat cancer and microbial infection

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