PEGylated ethyl cellulose micelles as a nanocarrier for drug delivery

Singam, Amarnath; Killi, Naresh; Patel, Pratikshkumar R.; Rathna, G. V. N.

doi:10.1039/d1ra04242d

Cited by 10 publications

(2 citation statements)

References 51 publications

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“…It is often desirable that the grafted polymers impart cellulose with different surface characteristics without modifying its intrinsic properties, such as nanodimension, crystallinity, and mechanical properties [ 9 ]. In particular, the grafting of poly(ethylene oxide) moieties onto cellulose has been reported for different applications in thermal energy storage [ 10 ], for the development of gel polymer electrolyte [ 11 ], to prepare biosensors [ 12 ] and more flexible composites for packaging [ 13 ] or drug delivery systems [ 14 ]. In our earlier report, we identified and characterized 2,6,6-tetra-methylpiperidine-1-oxyl (TEMPO) oxidized cellulose nanofiber (TOCNF) as an efficient substrate to graft ethylene glycol methyl ether acrylate [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Sponges from Plasma Treated Cellulose Nanofibers Grafted with Poly(ethylene glycol)methyl Ether Methacrylate

et al. 2022

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In this work, cellulose nanofibers (CNF) were surface treated by plasma and grafted with poly(ethylene glycol)methyl ether methacrylate (PEGMMA) for increasing mechanical strength and hydrophobicity. The surface characteristics of the sponges were studied by scanning electron microscopy, micro-computed tomography, and Fourier transform infrared spectroscopy, which demonstrated successful surface modification. Plasma treatment applied to CNF suspension led to advanced defibrillation, and the resulting sponges (CNFpl) exhibited smaller wall thickness than CNF. The grafting of PEGMMA led to an increase in the wall thickness of the sponges and the number of larger pores when compared with the non-grafted counterparts. Sponges with increased hydrophobicity demonstrated by an almost 4 times increase in the water contact angle and better mechanical strength proved by 2.5 times increase in specific compression strength were obtained after PEGMMA grafting of plasma treated CNF. Cells cultivated on both neat and PEGMMA-grafted CNF sponges showed high viability (>99%). Remarkably, CNF grafted with PEGMMA showed better cell viability as compared with the untreated CNF sample; this difference is statistically significant (p < 0.05). In addition, the obtained sponges do not trigger an inflammatory response in macrophages, with TNF-α secretion by cells in contact with CNFpl, CNF-PEGMMA, and CNFpl-PEGMMA samples being lower than that observed for the CNF sample. All these results support the great potential of cellulose nanofibers surface treated by plasma and grafted with PEGMMA for biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Sponges from Plasma Treated Cellulose Nanofibers Grafted with Poly(ethylene glycol)methyl Ether Methacrylate

et al. 2022

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“… [ 376 ] Nanoxel (nanoparticulate paclitaxel) Nanoxel is a nanoparticle configuration of paclitaxel, permitted for managing diverse cancer types like breast cancer, ovarian cancer, and non-small cell lung cancer. [ 377 ] Vyxeos (liposomal daunorubicin and cytarabine) Vyxeos is a liposomal formulation combining daunorubicin and cytarabine, authorized for treating acute myeloid leukemia in adults. [ 378 ] Marqibo (liposomal vincristine) Marqibo is a liposomal version of vincristine, approved for treating acute lymphoblastic leukemia in adult patients.…”

Section: Gap Until Clinical Studymentioning

confidence: 99%