PEGylated galactosylated cationic liposomes for hepatocytic gene delivery

Preparation, Physicochemical Properties, and Transfection Activities of Tartaric Acid-Based Cationic Lipids as Effective Nonviral Gene Delivery Vectors

“…[14][15][16][17][18][19][20][21][22][23][24] Among the existing nonviral vectors, the cationic liposome, representing an attractive, alternative approach for gene delivery has a broad varity of advantages, such as biodegradability, easy preparation, good repeatability and potential clinical applications. [25][26][27][28][29] Cationic lipids generally consist of polar head group and hydrophobic tails connected through the backbone (Fig. 1), while most of the backbone in earlier cationic lipids was classified into glycerol-type just as N- [2-[(1,5,10,14-tetraazatetradecane-1-yl) carbonylamino] ethyl]-N,Ndimethyl-2,3-bis(oleoyloxy)-1-propanaminium (DOSPA) and N- [2,3-dioleoyloxypropyl]-N,N,N-trimethylammonium chloride (DOTAP) 30,31) and cholesterol-type, such as 3β-[N-(N′,N′-dimethylaminoethyl) carbamoyl] cholesterol (DC-Chol).…”

Recent progress in gene therapy to deliver nucleic acids with multivalent cationic vectors

“…In this case, polyplexes are directly prepared with the cationic polymer (or a neutral polymer + pendant cationic molecules) and the nucleic acid. In general, cationic polymers, poly-L-lysines (PLL) and poly-L-arginines (PLA) [126,127]; (c) carbohydrate-based polymers in which the charge is mainly supplied by cationic cyclodextins, glycoamines and so on [128][129][130]; and (d) dendrimers-based polymers as polyamidoaminme (PAMAM) and others [131][132][133]. In addition, electrostatic interaction has been also analyzed in complexes where polycations, based on amphiphilic polycationic cyclodextrins [100,134,135] and calixarenes [136], were used as gene vectors of plasmid DNA or siRNA.…”

Non-viral gene delivery systems for tissue repair and regeneration

“…Furthermore, it was demonstrated that fibres loaded with pDNA polyplexes containing 10% PEG showed the best performance in terms of balancing transfection efficiency and cell viability [ 62 ]. Concerning lipid-based vectors, PEG can be used to form a protective coating on the surface of a vector, which is then likely to be opsonised and eliminated in the serum; and several PEGylated galactosylated cationic liposomes have been developed [ 63 ].…”