PEGylated hollow pH‐responsive polymeric nanocapsules for controlled drug delivery

Massoumi, Bakhshali; Abbasian, Mojtaba; Jahanban‐Esfahlan, Rana; Motamedi, Sanaz; Samadian, Hadi; Rezaei, Aram; Derakhshankhah, Hossein; Farnudiyan‐Habibi, Amir; Jaymand, Mehdi

doi:10.1002/pi.5987

Cited by 47 publications

(21 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, providing innovative chemical methods to increase the solubility and functionality of chitosan and derivatives in aqueous conditions can increase the use of these biocompatible polymers in pharmaceutical and medical. Chemical modification of chitosan can alter the balance between hydrophilic and hydrophobic groups and endowing the cell specificity 14 – 16 .…”

Section: Introductionmentioning

confidence: 99%

A pseudohomogeneous nanocarrier based on carbon quantum dots decorated with arginine as an efficient gene delivery vehicle

Rezaei

Hashemi

2021

Sci Rep

Self Cite

View full text Add to dashboard Cite

A pseudohomogeneous carrier as an emerging term refers to subnanometric carbon-based vehicle with a high ability to interact with genetic materials to form stable carboplex and successfully transfer them into the cell which will result in inhibiting or expressing of therapeutic genes. Chitosan is a non-toxic polyaminosaccharide used as a precursor in the presence of citric acid to produce carbon quantum dots (CQDs), which decorated with arginine as a surface passivation agent with high amine density in hydrothermal methodology. The Arginine-CQDs are comprehensively characterized by Fourier-transform infrared spectroscopy (FT-IR), Ultraviolet–visible spectroscopy (UV–vis), Atomic force microscopy (AFM), field emission scanning electron microscope (FE-SEM), Energy-dispersive X-ray (EDX) mapping, fluorescence, High-resolution transmission electron microscopy (HR-TEM), zeta potential and X-ray powder diffraction (XRD). In this regard, for the first time, carboplex are formed by electrostatic conjugating of Arginine-CQDs with DNA to protect it from enzymatic degradation. Moreover, the carboplex, like the chitosan precursor, has not shown toxicity against AGS cell line. Interestingly, the Arginine-CQDs have exhibited an excellent ability to overcome cell barriers to deliver into cells compared to chitosan at the same weight ratio. The Arginine-CQDs/pEGFP (W/W) nanocomplex, not only lead to transfection with a relatively higher efficiency than PEI polymer, which is the “golden standard”, but carboplex also demonstrates no significant toxicity. Indeed, the EGFP expression level has reached to 2.4 ± 0.2 via Arginine-CQDs carboplex at W/W 50 weight ratio. To the best of our knowledge, this is the first report includes chitosan-based CQDs functionalized by arginine which is applied to serve as a pseudohomogeneous vehicle for gene transfection.

show abstract

Section: Introductionmentioning

confidence: 99%

A pseudohomogeneous nanocarrier based on carbon quantum dots decorated with arginine as an efficient gene delivery vehicle

Rezaei

Hashemi

2021

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…Nanomaterials and nanotechnology as the enabling approaches have promising effects on the conventional structures and processes 9–11 . Nanomaterials exhibit altered and modified performance compared with the bulk counterparts 12–15 .…”

Section: Introductionmentioning

confidence: 99%

“…Nanomaterials exhibit altered and modified performance compared with the bulk counterparts 12–15 . Moreover, it is possible to modify the properties and performance of conventional materials and structures modified by the implementation of nanomaterials 11,16–19 . NPs synthesized from high Z materials, such as gold NPs, exhibit X‐ray attenuating performance.…”

Section: Introductionmentioning

confidence: 99%

Microfibers nanocomposite based on polyacrylonitrile fibers/bismuth oxide nanoparticles as X‐ray shielding material

Rashidi

Rezaei

Bijari

et al. 2021

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

The main focus of the current study was to fabricate fibrous nanocomposite based on polyacrylonitrile (PAN) fibers containing Bi2O3 NPs as the X‐ray shielding material. Bi2O3 NPs were synthesized based on the solid dispersion evaporation method and dispersed into PAN polymer solution with different weight concentrations. The electrospinning technique was used to fabricate nanocomposite. The morphology, surface functional group, wettability, elemental analysis, and X‐ray shielding efficacy of the fabricated nanocomposite were thoroughly evaluated. The dimeter of the fibrous nanocomposites containing 10, 20, and 30 wt% Bi2O3 NPs were 1.33 ± 0.08, 1.01 ± 0.11, and 1.69 ± 0.32 μm, respectively. EDX elemental analysis showed that NPs were uniformly distributed into/onto the fibers. The X‐ray shielding studies showed that the prepared nanocomposites effectively attenuate the intensity of the X‐ray. The entrance surface dose for the negative control was 24.10 ± 1.71 mSv and the application of the nanocomposites significantly reduced the entrance surface dose. The results showed NPs concentration‐dependent CT number shift as the indication of X‐ray protection and the highest value was obtained by 30 wt% NPs. The obtained results implied that the fabricated nanocomposites effectively attenuate the radiation and they could be applied as the X‐ray shielding materials.

show abstract

“…For example, Youssef et al [15] prepared nanostructured lipid carriers loaded in an in situ gel system, which was able to prolong the residence time on the ocular surface after topical administration. Massoumi's group obtained novel pH-responsive PEGylated hollow nanocapsules, which had excellent potential for cancer chemotherapy [16]. The drug carriers are mainly from natural or synthetic polymeric hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Preparation and application of pH-responsive composite hydrogel beads as potential delivery carrier candidates for controlled release of berberine hydrochloride

et al. 2020

View full text Add to dashboard Cite

For improving the effective concentration of berberine hydrochloride (BH) in the gastrointestinal tract, a series of pH-responsive hydrogel beads were prepared based on carboxymethylstarch-g-poly (acrylic acid)/palygorskite/starch/sodium alginate (CMS-g-PAA/PGS/ST/SA) in the present work. The developed hydrogel beads were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TG). Effect of palygorskite (PGS) content on the swelling properties of hydrogel beads and BH cumulative release were discussed. The pH responsiveness of hydrogel beads was also investigated in different media. Results illustrated that swelling of hydrogel beads and BH cumulative release from hydrogel beads were obviously affected by PGS content. The swelling ratio and BH cumulative release of composite hydrogel beads remarkably slowed down with PGS content increasing in the range from 10 to 40 wt%. The composite hydrogel beads were pH-responsive. At pH 7.4, the swelling ratio and BH cumulative release from composite hydrogel beads were the fastest among the dissolution media of pH 1.2, pH 6.8 and pH 7.4. The BH cumulative release from hydrogel beads was related to the swelling and relaxation of composite hydrogel beads and could be fitted better by the Higuchi model. The obtained composite hydrogel beads could be potentially used for the development of BH pharmaceutical dosage forms.

show abstract

PEGylated hollow pH‐responsive polymeric nanocapsules for controlled drug delivery

Cited by 47 publications

References 29 publications

A pseudohomogeneous nanocarrier based on carbon quantum dots decorated with arginine as an efficient gene delivery vehicle

A pseudohomogeneous nanocarrier based on carbon quantum dots decorated with arginine as an efficient gene delivery vehicle

Microfibers nanocomposite based on polyacrylonitrile fibers/bismuth oxide nanoparticles as X‐ray shielding material

Preparation and application of pH-responsive composite hydrogel beads as potential delivery carrier candidates for controlled release of berberine hydrochloride

Contact Info

Product

Resources

About