PEGylated Lecithin–Chitosan–Folic Acid Nanoparticles as Nanocarriers of Allicin for In Vitro Controlled Release and Anticancer Effects

Hashemy, Seyed Isaac; Amiri, Hamed; Hosseini, Hossein; Sadeghzadeh, Farzaneh; Jaseem, Muslem Mohammed Mosa; Tabrizi, Masoud Homayouni

doi:10.1007/s12010-022-04310-y

Cited by 8 publications

(4 citation statements)

References 49 publications

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“…Their application notably increased allicin toxicity by upsurging caspase 3 and 9 expression and activation of intrinsic apoptotic cascade in treated cancer cells. Additionally, it also confirmed allicin’s anti-angiogenic effects [ 30 ]. Concludingly, combining allicin with several nano-carriers may not only increase its cellular delivery and bioavailability but also have therapeutic implications.…”

Section: Allicinmentioning

confidence: 59%

Allicin and Cancer Hallmarks

Talib,

Baban,

Azzam

et al. 2024

Molecules

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Natural products, particularly medicinal plants, are crucial in combating cancer and aiding in the discovery and development of new therapeutic agents owing to their biologically active compounds. They offer a promising avenue for developing effective anticancer medications because of their low toxicity, diverse chemical structures, and ability to target various cancers. Allicin is one of the main ingredients in garlic (Allium sativum L.). It is a bioactive sulfur compound maintained in various plant sections in a precursor state. Numerous studies have documented the positive health benefits of this natural compound on many chronic conditions, including gastric, hepatic, breast, lung, cervical, prostate, and colon cancer. Moreover, allicin may target several cancer hallmarks or fundamental biological traits and functions that influence cancer development and spread. Cancer hallmarks include sustained proliferation, evasion of growth suppressors, metastasis, replicative immortality, angiogenesis, resistance to cell death, altered cellular energetics, and immune evasion. The findings of this review should provide researchers and medical professionals with a solid basis to support fundamental and clinical investigations of allicin as a prospective anticancer drug. This review outlines the anticancer role of allicin in each hallmark of cancer.

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Section: Allicinmentioning

confidence: 59%

Allicin and Cancer Hallmarks

Talib,

Baban,

Azzam

et al. 2024

Molecules

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“…Hashemy et al prepared allicin-loaded chitosan−egg phospholipid nanoparticles (AC-PLCF-NPs) modified with polyethylene glycol and folic acid by a self-assembling method. 82 The AC-PLCF-NPs had an average diameter of 113.55 nm and an allicin EE of 81%. Biological studies showed that AC-PLCF-NPs exhibited high inhibitory activity against Gram-negative bacterial strains and increased cytotoxicity against HT-29 cancer cells compared to free allicin.…”

Section: ■ Delivery Systemsmentioning

confidence: 99%

“…The cytotoxicity against HepG2 cells was also enhanced by 3-fold compared with free unformulated allicin. Hashemy et al prepared allicin-loaded chitosan–egg phospholipid nanoparticles (AC-PLCF-NPs) modified with polyethylene glycol and folic acid by a self-assembling method . The AC-PLCF-NPs had an average diameter of 113.55 nm and an allicin EE of 81%.…”

Section: Delivery Systemsmentioning

confidence: 99%

Bioavailability, Health Benefits, and Delivery Systems of Allicin: A Review

Deng,

Ho,

Lan

et al. 2023

J. Agric. Food Chem.

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Garlic has been used worldwide as a spice due to its pungent taste and flavor-enhancing properties. As a main biologically active component of the freshly crushed garlic extracts, allicin (diallyl thiosulfinate) is converted from alliin by alliinase upon damaging the garlic clove, which has been reported to have many potent beneficial biological functions. In this work, allicin formation, stability, bioavailability, and metabolism process are examined and summarized. The biological functions of allicin and potential underlying mechanisms are reviewed and discussed, including antioxidation, anti-inflammation, antidiabetic, cardioprotective, antineurodegenerative, antitumor, and antiobesity effects. Novel delivery systems of allicin with enhanced stability, encapsulation efficiency, and bioavailability are also evaluated, such as nanoparticles, gels, liposomes, and micelles. This study could provide a comprehensive understanding of the physiochemical properties and health benefits of allicin, with great potential for further applications in the food and nutraceutical industries.

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“…A recent study discovered that the allicin-loaded polylactic acid–glycolic acid nanoparticles enhanced the encapsulation efficiency and drug-loading capacity of allicin, while also ensuring a consistent controlled-release rate of allicin in an acidic environment [ 87 ]. Hashemy et al [ 90 ] developed polyethylene glycol and folic acid-modified chitosan-egg phospholipid nanoparticles loaded with allicin (AC-PLCF-NPs), which demonstrated potent inhibitory activity against Gram-negative bacterial strains and enhanced cytotoxicity against HT-29 cancer cells compared to free allicin. Chen et al [ 86 ] developed a functionalized adipo-8 aptamer loaded with allicin to form a synergistic binary-drug delivery system for treating obesity.…”

Section: Noval Nanotechnology-based Drug Delivery Strategies Of Allicinmentioning

confidence: 99%

Therapeutic potentials of allicin in cardiovascular disease: advances and future directions

Gao,

Wang,

Qin

et al. 2024

Chin Med

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Cardiovascular disease (CVD) remains the predominant cause of mortality and disability worldwide. Against this backdrop, finding effective drugs for the pharmacological treatment of CVD has become one of the most urgent and challenging issues in medical research. Garlic (Allium sativum L.) is one of the oldest plants and is world-renowned for its dietary and medicinal values. Allicin (diallyl thiosulfinate) is one of the primary natural active ingredients in garlic, which has been proven to have powerful cardioprotective effects and mediate various pathological processes related to CVD, such as inflammatory factor secretion, myocardial cell apoptosis, oxidative stress, and more. Therefore, allicin holds a promising application prospect in the treatment of CVD. This review summarized the biological functions of allicin and its potential mechanisms in CVD, including antioxidation, anti-inflammation, and anti-apoptosis effects. Reckoning with these, we delved into recent studies on allicin’s cardioprotective effects concerning various CVDs, such as atherosclerosis, hypertension, myocardial infarction, arrhythmia, cardiac hypertrophy, heart failure, and cardiotoxicity. Further, considering the tremendous advancement in nanomedicine, nanotechnology-based drug delivery systems show promise in addressing limitations of allicin’s clinical applications, including improving its solubility, stability, and bioavailability. Through this review, we hope to provide a reference for further research on allicin in cardioprotection and drug development. Graphical Abstract

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PEGylated Lecithin–Chitosan–Folic Acid Nanoparticles as Nanocarriers of Allicin for In Vitro Controlled Release and Anticancer Effects

Cited by 8 publications

References 49 publications

Allicin and Cancer Hallmarks

Allicin and Cancer Hallmarks

Bioavailability, Health Benefits, and Delivery Systems of Allicin: A Review

Therapeutic potentials of allicin in cardiovascular disease: advances and future directions

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