Pegylated magnetic mesoporous silica nanoparticles decorated with AS1411 Aptamer as a targeting delivery system for cytotoxic agents

Improving anti-cancer drug delivery performance of magnetic mesoporous silica nanocarriers for more efficient colorectal cancer therapy

“…For instance, Sakhtianchi et al reported significant difference ( p < 0.05) between toxicity profile of DOX-PEG-MMSNs and DOX-APT-PEG-MMSNs. Their results indicated that targeted nanocarriers were more toxic in compression with non-targeted nanocarriers in case of MCF-7 cells [ 59 ]. Moreover, Siminzar et al .…”

“…In the past decade, development of targeted MSNs has had a great impact on specific cancer cell recognition and increasing the therapeutic efficacy. For instance, it has been shown that recruiting the AS1411 and mucin-1 (MUC-1) as conventional targeting aptamers on the surface of MSNs can significantly increase selective delivery of DOX and strong toxicity against MCF-7 breast cancer cells [ 59 , 60 ]. Hyaluronic acid (HA) is another targeting ligand, which has been widely conjugated to the MSNs for specific recognition of CD44 overexpressing colon cancer cells [ 61 – 63 ].…”

Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis

“…Moreover, failure in induction of apoptosis, as a consequence of aberrant expression of antigens, secreted angiogenic growth factors, or their receptors has already been linked to an elevated risk of metastasis, promotion of angiogenesis and an accelerated risk of resistance development to anti‐angiogenic cancer therapies. 21 , 22 , 23 , 24 , 25 , 26 , 27 Either mediated by the extrinsic (mediated by FASL, TNFα and so on) or intrinsic pathway (most importantly, accumulation of ROS and development of oxidative stress), the rest of the process will be followed by modulation of specific sets of procaspase molecules cleavage (caspase 8 and caspase 9 for extrinsic and intrinsic pathways respectively), ending in degradation of numerous intracellular target proteins, blebbing of cellular membrane, cleavage and degradation of chromosomal DNA, and finally, getting phagocytosed and scavenged by polymorphonuclear cells. 28 Apoptosis can be triggered upon activation of two main pathways which are broadly referred as “intrinsic” and “extrinsic” pathways.…”

Aptamer-functionalized nanomaterials for biological applications

“…Dinarvand and co-colleagues developed aptamer-functionalized polyethylene glycol coated superparamagnetic iron oxide nanoparticle (SPION)/mesoporous silica core-shell nanoparticles for simultaneous targeted cancer therapy and magnetic resonance imaging for the development of nanomaterials with thermal diagnostic capabilities. 51 Precise control the structure of metal nanomaterials is also of great significance for the development of advanced nanobiological technologies. Some assembly techniques have been shown to provide methods for the immobilization of nanoscale particles and to obtain highly dispersed nanomaterials.…”