PEGylated poly(lactic-<i>co</i>-glycolic acid) nanoparticles doped with molybdenum-iodide nanoclusters as a promising photodynamic therapy agent against ovarian cancer

Verger, Alexis; Dollo, Gilles; Brandhonneur, Nolwenn; Martinais, Sophie; Cordier, Stéphane; Lang, Kamil; Amela-Cortés, Maria; Kirakci, Kaplan

doi:10.1039/d3ma00206c

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…Interestingly, 2 was localized in the cell cytoplasm (Fig. 5C), similar to previously reported Mo 6 @PLGA-PEG nanoparticles, 26 but also in the lysosomes as already reported for pure Mo 6 clusters (Fig. 5D).…”

Section: Uptake and Localizationsupporting

confidence: 88%

Radiosensitizing molybdenum iodide nanoclusters conjugated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer: a step towards radiodynamic therapy

Kirakci,

Pola,

Tavares

et al. 2023

Mater. Adv.

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Section: Uptake and Localizationsupporting

confidence: 88%

Radiosensitizing molybdenum iodide nanoclusters conjugated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer: a step towards radiodynamic therapy

Kirakci,

Pola,

Tavares

et al. 2023

Mater. Adv.

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“…The phototoxicity of 1 is comparable to that of the most efficient Mo 6 -based nanosystems, such as cluster-loaded PLGA nanoparticles. , However, in contrast to these systems, 1 had no dark toxicity at high Mo 6 concentrations. Several molecular Mo 6 photosensitizers showed even lower IC 50 values for phototoxicity.…”

Section: Resultsmentioning

confidence: 95%

PEGylated Molybdenum–Iodine Nanocluster as a Promising Radiodynamic Agent against Prostatic Adenocarcinoma

Přibyl,

Rumlová,

Mikyšková

et al. 2024

Inorg. Chem.

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The combination of photodynamic therapy and radiotherapy has given rise to a modality called radiodynamic therapy (RDT), based on reactive oxygen species-producing radiosensitizers. The production of singlet oxygen, O 2 ( 1 Δ g ), by octahedral molybdenum (Mo 6 ) clusters upon X-ray irradiation allows for simplification of the architecture of radiosensitizing systems. In this context, we prepared a radiosensitizing system using copper-free click chemistry between a Mo 6 cluster bearing azido ligands and the homo-bifunctional linker bis-dPEG 11 -DBCO. The resulting compound formed nanoparticles, which featured production of O 2 ( 1 Δ g ) and efficient cellular uptake, leading to remarkable photo-and radiotoxic effects against the prostatic adenocarcinoma TRAMP-C2 cell line. Spheroids of TRAMP-C2 cells were also used for evaluation of toxicity and phototoxicity. In vivo experiments on a mouse model demonstrated that subcutaneous injection of the nanoparticles is a safe administration mode at a dose of up to 0.08 g kg −1 . The reported results confirm the relevancy of Mo 6 -based radiosensitizing nanosystems for RDT.

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Functional materials containing luminescent octahedral halide clusters of molybdenum and tungsten: Diversity of synthetic approaches and binding modes

Vorotnikova,

Vorotnikov,

Shestopalov

2024

Coordination Chemistry Reviews

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PEGylated poly(lactic-co-glycolic acid) nanoparticles doped with molybdenum-iodide nanoclusters as a promising photodynamic therapy agent against ovarian cancer

Abstract: Photodynamic applications requires efficient intracellular uptake of the photosensitizer that can be achieved throught the development of nanoscaled delivery system. Herein, we prepared PEGylated poly(lactic-co-glycolic acid) nanoparticles doped with an...

Cited by 3 publications

References 36 publications

Radiosensitizing molybdenum iodide nanoclusters conjugated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer: a step towards radiodynamic therapy

Radiosensitizing molybdenum iodide nanoclusters conjugated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer: a step towards radiodynamic therapy

PEGylated Molybdenum–Iodine Nanocluster as a Promising Radiodynamic Agent against Prostatic Adenocarcinoma

Functional materials containing luminescent octahedral halide clusters of molybdenum and tungsten: Diversity of synthetic approaches and binding modes

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