PEGylation and BioPEGylation of Polyhydroxyalkanoates: Synthesis, Characterisation and Applications

Foster, Lisa

doi:10.5772/10265

Cited by 9 publications

(21 citation statements)

References 48 publications

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“…PEGylation is a solution to increase the bioavailability of the decorated nanostructures and to extend the circulating lifetime [97]. After this modification a protein corona is formed around the antifouling PEG functionalization [98]. It will create a hindered zone around the nanoparticles and reduces the wrapping by plasma proteins and the subsequent uptake by macrophages PEGylation depends on many factors such as hydrophilicity of the PEG chains, molecular weight (MW) which vary from 2000 to 13,000 Da.…”

Section: Pegylationmentioning

confidence: 99%

New Developments in Medical Applications of Hybrid Hydrogels Containing Natural Polymers

Vasile¹,

Pamfil²,

Stoleru³

et al. 2020

Molecules

211

131

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New trends in biomedical applications of the hybrid polymeric hydrogels, obtained by combining natural polymers with synthetic ones, have been reviewed. Homopolysaccharides, heteropolysaccharides, as well as polypeptides, proteins and nucleic acids, are presented from the point of view of their ability to form hydrogels with synthetic polymers, the preparation procedures for polymeric organic hybrid hydrogels, general physico-chemical properties and main biomedical applications (i.e., tissue engineering, wound dressing, drug delivery, etc.).

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Section: Pegylationmentioning

confidence: 99%

New Developments in Medical Applications of Hybrid Hydrogels Containing Natural Polymers

Vasile¹,

Pamfil²,

Stoleru³

et al. 2020

Molecules

211

131

View full text Add to dashboard Cite

show abstract

“…For the application of synthetic polymers as biomaterials, their hydrophilization by conjugation or blending with polyethylene glycol (PEG) (PEGylation) or the conjugation to functional biomolecules (bioconjugation) are very important strategies. [26][27][28][29][30][31][32] Furthermore, blending with some natural polymers or with naturally derived polymers (e.g., celluloses) is also a very important concept. [33,34] Encapsulation of stem cells in hydrogels composed of gelatin methacrylate and poly(ethylene…”

Section: Doi: 101002/marc201900091mentioning

confidence: 99%

Polyamide/PEG Blends as Biocompatible Biomaterials for the Convenient Regulation of Cell Adhesion and Growth

Winnacker

Béringer

Gronauer

et al. 2019

Macromol. Rapid Commun.

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In addition to their established usage in textiles, commodities, and automotives, classical polyamides (nylons) are recently becoming increasingly interesting for applications in (bio)medicine. This fact relies on many prosperous properties of these polymers, which are toughness, resistance, biocompatibility, low immunogenicity, tunable biodegradability, and their similarity to natural peptides (amide bonds). Some nylon‐based medical products do already exist for wound treatment applications, implants, and biomolecule‐interacting membranes, but the systematic use of these polymers for tissue engineering is—although desired—still to be accomplished. Inspired by this, the suitability of nylon 6 and of a related biobased and more hydrophobic terpene‐derived polyamide as surfaces for the controlled interaction with HaCat cells (human keratinocytes) are investigated herein with regard to possible applications for regenerative skin replacement. The nylons are applied as neat polymers and as hydrophilized blends/composites with polyethylene glycol and confirm their excellent suitability as biomaterials.

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“…PEG 200) provide some influence in and control over PHA monomeric composition by promoting the monomer type which is mainly available in the source. Modulation of PHA molecular weight in the presence of PEG in the bioprocessing system has also been proved …”

Section: Introductionmentioning

confidence: 97%

“…For this hydrophilization via copolymerization, mainly PEGylation (attachment of PEG) and ‘bioPEGylation’ have been shown to be useful procedures . While PEGylation is mainly referred to as a synthetic procedure, bioPEGylation is referred to as the PEG incorporation in vivo by certain (micro)organisms.…”

Section: Introductionmentioning

confidence: 99%

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Copolymers of polyhydroxyalkanoates and polyethylene glycols: recent advancements with biological and medical significance

Winnacker

Rieger

2016

Polymer International

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Copolymers of polyhydroxyalkanoates (PHAs) and polyethylene glycols (PEGs) have gained high significance for biological and medical applications within the past few years. PHAs are natural biopolymers (hydrophobic biopolyesters), which can be produced microbially and also synthetically, and PEGs are biocompatible hydrophilic polyethers, which are frequently used in medicine to enhance the effect of bioactive compounds. Both polymers can be conjugated with a variety of other polymers, and in particular the conjugation with each other affords hydrophobic − hydrophilic PHA‐PEG copolymers with high significance as biomaterials. This paper describes selected recent developments in this field with a focus on synthetic approaches and the suitability of the resulting copolymers for applications in drug delivery and tissue engineering. © 2016 Society of Chemical Industry

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PEGylation and BioPEGylation of Polyhydroxyalkanoates: Synthesis, Characterisation and Applications

Cited by 9 publications

References 48 publications

New Developments in Medical Applications of Hybrid Hydrogels Containing Natural Polymers

New Developments in Medical Applications of Hybrid Hydrogels Containing Natural Polymers

Polyamide/PEG Blends as Biocompatible Biomaterials for the Convenient Regulation of Cell Adhesion and Growth

Copolymers of polyhydroxyalkanoates and polyethylene glycols: recent advancements with biological and medical significance

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