PEGylation corannulene enhances response of stress through promoting neurogenesis

Abstract

Carbon nanomaterials have been used to treat neurodegenerative diseases and neural disorders due to their diverse molecular structures. Corannulene is a three-dimensional π-bowl carbon nanomaterial that is different from planar PAHs, fullerenes and carbon nanotubes, but little is known about its biological functions. Herein, corannulene was functionalized with mPEG-DESP to prepare PEGylation corannulene nanoparticles (PEGylation CoNps). The synthesized PEGylation CoNps shows enhanced solubility and reduced aggregation when compared corannulene. Then, in vivo experiments were performed to determine the effects of PEGylation CoNps on the neural system. We found that PEGylation CoNps treatment increased short resting bouts, decreased locomotion activities and enhanced the response to stress. Most of these behavioral changes suggest that PEGylation CoNps lead to a greater reflection to stress, which is associated with neurotransmitter expression and neurogenesis. In line with the hypothesis, we found that PEGylation CoNps administration enhanced TH, DCX and MAP-2 expression in the hippocampus. These results indicated that PEGylation CoNps enhanced the neurogenesis of mice. Furthermore, pathological analysis showed that PEGylation CoNps caused little inflammation. These findings suggest that PEGylation CoNps are a potential functionalized carbon nanomaterial for promoting neurogenesis.

Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F‐actin in zygotes and leads to cognitive and social disorders in offspring mice

“…The dark/light transition test was measured as described in a previously study. 35 Mice were placed on the dark side (L × W × H; 40 × 40 × 40 cm) of a light-dark transition apparatus and were allowed to freely move into the light side via an opening (5 cm × 7 cm). The light side was brightly illuminated (50 ± 0.5 lux) and the dark side was dimly lit (0.5 ± 0.2 lux).…”

Diazapentabenzocorannulenium: A Hydrophilic/Biophilic Cationic Buckybowl

“…The significant progress and application of polycyclic aromatic molecules in material sciences, especially in organic electronics, are mainly based on their intrinsic hydrophobic properties [6, 7] . In order to further extend possible applications, for example in biological or medicinal research, the development of highly‐soluble/hydrophilic molecules is desirable [8, 9] . The most conventional method to achieve water‐soluble polycyclic aromatic molecules is to add hydrophilic substituents at their peripheral positions (Figure 1a) [10–16] .…”

“…[6,7] In order to further extend possible applications, for example in biological or medicinal research, the development of highlysoluble/hydrophilic molecules is desirable. [8,9] The most conventional method to achieve water-soluble polycyclic aromatic molecules is to add hydrophilic substituents at their peripheral positions (Figure 1a). [10][11][12][13][14][15][16] However, the method may not be ideal in terms of step economy as it requires some additional steps for functionalization.…”

Diazapentabenzocorannulenium: A Hydrophilic/Biophilic Cationic Buckybowl

“…The significant progress and application of polycyclic aromatic molecules in material sciences, especially in organic electronics, are mainly based on their intrinsic hydrophobic properties [6, 7] . In order to further extend possible applications, for example in biological or medicinal research, the development of highly‐soluble/hydrophilic molecules is desirable [8, 9] . The most conventional method to achieve water‐soluble polycyclic aromatic molecules is to add hydrophilic substituents at their peripheral positions (Figure 1a) [10–16] .…”