PEGylation of chitosan for improved solubility and fiber formation via electrospinning

Du, Junbao; Hsieh, You‐Lo

doi:10.1007/s10570-007-9122-3

Cited by 85 publications

(54 citation statements)

References 23 publications

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“…We have synthesized water and organic soluble chitosan derivatives and electrospun them into fibers Hsieh 2007, 2008). PEGylated chitosan nanofibers with an average diameter of 162 nm were electrospun from 75/25 (v/v) THF/dimethylformamide coslovents with 0.5% Triton X-100 (Du and Hsieh 2007). Carboxylation of chitosan enabled water solubility, allowing electrospinning from aqueous solutions to form carboxylated chitosan/PVA bicomponent nanofibers with 135 nm average diameter (Du and Hsieh 2008).…”

Section: Introductionmentioning

confidence: 99%

Cellulose/chitosan hybrid nanofibers from electrospinning of their ester derivatives

Hsieh

2008

Cellulose

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A facile approach has been established to generate cellulose/chitosan hybrid nanofibers with full range of compositions by electrospinning of their ester derivatives, cellulose acetate (CA) and dibutyryl chitin (DBC), followed by alkaline hydrolysis to cellulose (Cell) and chitosan (CS). DBC was synthesized by acid-catalyzed acylation of chitin (CHI) with butyric anhydride and the newly formed butyl groups on C3 and C6 were confirmed by FT-IR and 1 HNMR. DBC had robust solubility in acetone, DMAc, DMF, ethanol, and acetic acid, all except ethanol were also solvents for CA, allowing mixing of these ester derivatives. Fiber formation by electrospinning of either DBC or CA alone and together in these common solvents and their mixtures were studied. The 1/1 acetone/acetic acid was found to be the optimal solvent system to generate fibers from either DBC or CA as well as their mixtures at all CA/DBC ratios, resulting in hybrid fibers with diameters ranging from 30 to 350 nm. DBC and CA were well mixed and showed no phase separate in the hybrid fibers. Alkaline hydrolysis (NaOH) of the equal mass CA/DBC nanofibers regenerated Cell and CHI readily via O-deacylation, then proceeded to further deacetylate CHI to CS via N-deacetylation at higher alkaline concentrations and/or temperatures. Under conditions studied, hydrolysis with 5N NaOH at 100°C for 3 h was optimal to regenerate cellulose/ chitosan hybrid nanofibers.

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Section: Introductionmentioning

confidence: 99%

Cellulose/chitosan hybrid nanofibers from electrospinning of their ester derivatives

Hsieh

2008

Cellulose

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“…Another interesting approach to overcome the problem of solubility of chitosan is PEGylation. Du and Hsieh [84] …”

Section: Chitosanmentioning

confidence: 99%

A review on electrospun bio-based polymers for water treatment

Mokhena¹,

Jacobs²,

Luyt³

2015

Express Polym. Lett.

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Abstract. Over the past decades, electrospinning of biopolymers down to nanoscale garnered much interest to address most of the millennia issues related to water treatment. The fabrication of these nanostructured membranes added a new dimension to the current nanotechnologies where a wide range of materials can be processed to their nanosize. Electrospinning is a simple and versatile technique to fabricate unique nanostructured membranes with fascinating properties for a wide spectrum of applications such as filtration and others. These nanostructured membranes, fabricated by electrospinning, were found to be of a paramount importance because of their advanced inherited properties such as large surface-to-volume ratio, as well as tuneable porosity, stability, and high permeability. The extensive research conducted on these materials extended the success of electrospinning not only to bio-based polymer nanofibres, but to their hybrids and their derivatives. The technique also created avenues for advanced and massive production of nanofibres. This paper reviews the recent developments in the electrospinning technique. Electrospinning of biopolymers, their blends and functionalization using metals/metal oxides, and the potential applications of electrospun nanofibrous membranes in water filtration are discussed.

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“…25 Briefly, CA with a DS of 0.2 was obtained by hydrolysis in NaOH/ethanol (0.05M) for 30 min. Meanwhile, CA with a DS of 1.14 was prepared by aqueous hydrolysis (0.05M) at ambient temperature for 140 min.…”

Section: Fabrication Of Cellulose Fibrous Templatesmentioning

confidence: 99%

“…5(a)], consistent with our prior observation on CS. 25 DXS exhibited the typical 27 Following the (CS/DXS) 5 bilayer LBL deposition on CA2.45 [ Fig. 5(c)], the coated fibers showed a higher relative ether-to-carbonyl intensity ratio than that of the original CA2.45 template fibers [ Fig.…”

Section: Lbl Biofilm Formationmentioning

confidence: 99%

Tubular multi‐bilayer polysaccharide biofilms on ultra‐thin cellulose fibers

Ding

Hsieh

2011

J of Applied Polymer Sci

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Multiple bilayered polysaccharide biofilms have been assembled by electrostatic layer-by-layer (LBL), alternating deposition of cationic chitosan (CS, M v ¼ 405 kDa) and anionic dextran sulfate (DXS, M w ¼ 500 kDa) onto ultra-fine cellulose (CELL) and partially hydrolyzed cellulose acetate fibers with diameters ranging from 350 to 410 nm. While the surfaces of partially hydrolyzed (degrees of substitution of 1.14 or 0.2) and CELL fibers were equally hydrophilic, higher surface charges on the more hydrolyzed fibers afford thicker bilayers. The elestrostatic interactions between CS and DXS were enhanced by the presence of NaCl in the dipping and rinsing solutions to allow uniform deposition of sequential polysaccharide bilayers. At 0.25M NaCl, each CS/DXS bilayer averaged 6.4 to 9.0 nm thick with the total thickness of the five bilayer (CS/DXS) 5 varied from 64 to 77 nm. The CS/DXS bilayers exhibited much reduced BET surface area and pore volume indicating that these polysaccharides were much more densely packed on the fully hydrolyzed CELL fibers. The findings proofed the concept that long chain polysaccharide electrolytes can be self-assembled as nanometer scale tubular bilayers on ultra-fine cellulose fibers to afford wholly polysaccharidic fibrous architecture. The electrolytic nature, chemical reactivity, and structural versatility of these ultra-high specific surface polysaccharides are advantageous and can be further tuned to serve biological functions and for biomedical applications.

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PEGylation of chitosan for improved solubility and fiber formation via electrospinning

Cited by 85 publications

References 23 publications

Cellulose/chitosan hybrid nanofibers from electrospinning of their ester derivatives

Cellulose/chitosan hybrid nanofibers from electrospinning of their ester derivatives

A review on electrospun bio-based polymers for water treatment

Tubular multi‐bilayer polysaccharide biofilms on ultra‐thin cellulose fibers

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