PEI-coated Prussian blue nanocubes as pH-Switchable nanozyme: Broad-pH-responsive immunoassay for illegal additive

Liang, Hongzhi; Liu, Yuqiu; Qileng, Aori; Shen, Haoran; Liu, Weipeng; Xu, Zhenlin; Liu, Yingju

doi:10.1016/j.bios.2022.114797

Cited by 28 publications

(25 citation statements)

References 36 publications

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“…Furthermore, Liu and co‐workers synthesized polyethyleneimine‐coated Prussian blue nanocubes (PBNCs@PEI) nanozyme with the ability of pH‐switchable. [ 54 ] The nanozymes can switch POD‐like to CAT‐like activity via pH alters from acidic to alkaline, enabling it to execute distinct functions in multiple surroundings. For rationally designing the catalytic performance of nanozymes, Li and co‐workers displayed gold nanoparticle clusters (GNCs) nanozymes with adjustable POD‐like catalytic via altering the single‐stranded (ss‐) DNA scaffolds sequence.…”

Section: Activity Regulation Strategiesmentioning

confidence: 99%

Activity Regulating Strategies of Nanozymes for Biomedical Applications

Ding

Zhao

Zhang

et al. 2023

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On accounts of the advantages of inherent high stability, ease of preparation and superior catalytic activities, nanozymes have attracted tremendous potential in diverse biomedical applications as alternatives to natural enzymes. Optimizing the activity of nanozymes is significant for widening and boosting the applications into practical level. As the research of the catalytic activity regulation strategies of nanozymes is boosting, it is essential to timely review, summarize, and analyze the advances in structure–activity relationships for further inspiring ingenious research into this prosperous area. Herein, the activity regulation methods of nanozymes in the recent 5 years are systematically summarized, including size and morphology, doping, vacancy, surface modification, and hybridization, followed by a discussion of the latest biomedical applications consisting of biosensing, antibacterial, and tumor therapy. Finally, the challenges and opportunities in this rapidly developing field is presented for inspiring more and more research into this infant yet promising area.

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Section: Activity Regulation Strategiesmentioning

confidence: 99%

Activity Regulating Strategies of Nanozymes for Biomedical Applications

Ding

Zhao

Zhang

et al. 2023

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“…They made use of this property and established a dual-mode immunosensor for rosiglitazone (RSG) detection in a wide pH range. 75 Au nanostars (Au NSs) with variable localized surface plasmon resonance (LSPR) peak shifts and 4-chloro-1-naphthol (4-CN) with changeable fluorescence intensity were used to construct a dual-mode immunosensor with a colorimetric channel and fluorescence channel (Fig. 7B).…”

Section: Biomedical Applications Of Stimuli-responsive Nanozymesmentioning

confidence: 99%

“…Apart from turning the activities of nanozymes on/off, switching the activity from one to another under different stimuli has also aroused great interest in recent years. [66][67][68][69][70][71][72][73][74][75] Some nanozymes exhibit different enzyme-like activities under different conditions. For example, iron oxide nanoparticles (IONPs) show POD-like activity under acidic conditions and CAT-like activity under neutral conditions.…”

Section: One/another Switchable Catalytic Activity Of Nanozymesmentioning

confidence: 99%

“…Similarly, changing pH is one of the most common methods for switching the enzymatic activities of nanozymes. [66][67][68][73][74][75] These nanozymes show different enzyme-like activities under different pH conditions. For example, Prussian blue NPs (PBNPs) possess multi-enzymatic properties (POD-like activity, CAT-like activity and superoxide dismutase (SOD)-like activity) under acidic and neutral conditions.…”

Section: One/another Switchable Catalytic Activity Of Nanozymesmentioning

confidence: 99%

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Stimuli-responsive nanozymes for biomedical applications

Zhang

Tong

2023

Biomater. Sci.

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“…In addition, catalase-mimicking nanozymes can also be used to design a multimodal immunoassay. For example, pH-switchable nanozyme polyethyleneimine-coated Prussian blue nanocubes (PBNCs@PEI) were synthesized; they exhibited peroxidase-like activity in acidic pH and catalase-like activity in alkaline conditions [ 105 ]. The peroxidase-like activity of PBNCs@PEI in acidic pH could induce the colorimetric reaction of Au nanostars with TMB 2+ /CTAB, whereas the catalase-like activity of PBNCs@PEI in alkaline pH could catalyze the decomposition of H 2 O 2 to produce O 2 , which could further oxidize 4-chloro-1-naphthol (4-CN) with decreased fluorescence intensity.…”

Section: Immunoassay Based On Nanozymesmentioning

confidence: 99%

Recent Advances in the Immunoassays Based on Nanozymes

et al. 2022

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As a rapid and simple method for the detection of multiple targets, immunoassay has attracted extensive attention due to the merits of high specificity and sensitivity. Notably, enzyme-linked immunosorbent assay (ELISA) is a widely used immunoassay, which can provide high detection sensitivity since the enzyme labels can promote the generation of catalytically amplified readouts. However, the natural enzyme labels usually suffer from low stability, high cost, and difficult storage. Inspired by the advantages of superior and tunable catalytic activities, easy preparation, low cost, and high stability, nanozymes have arisen to replace the natural enzymes in immunoassay; they also possess equivalent sensitivity and selectivity, as well as robustness. Up to now, various kinds of nanozymes, including mimic peroxidase, oxidase, and phosphatase, have been incorporated to construct immunosensors. Herein, the development of immunoassays based on nanozymes with various types of detection signals are highlighted and discussed in detail. Furthermore, the challenges and perspectives of the design of novel nanozymes for widespread applications are discussed.

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PEI-coated Prussian blue nanocubes as pH-Switchable nanozyme: Broad-pH-responsive immunoassay for illegal additive

Cited by 28 publications

References 36 publications

Activity Regulating Strategies of Nanozymes for Biomedical Applications

Activity Regulating Strategies of Nanozymes for Biomedical Applications

Stimuli-responsive nanozymes for biomedical applications

Recent Advances in the Immunoassays Based on Nanozymes

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