Pelargonic acid vanillylamide and rosuvastatin protect against oxidized low-density lipoprotein-induced endothelial dysfunction by inhibiting the NF-κB/NLRP3 pathway and improving cell-cell junctions

Indoor metabolites and chemicals outperform microbiome in classifying childhood asthma and allergic rhinitis

“…Synthetic chemicals were also characterized as enriched compounds in the home dust of asthma and rhinitis children. Two studies reported that 2-methylpropanal and pelargonic acid could induce inflammation in respiratory epithelial cells and vascular endothelial cells [ 51 , 52 ]. Interestingly, these chemicals, along with diacetoxyscirpenol and pelargonic acid, can activate the expression of NF-κB, which leads to subsequent inflammatory symptoms [ 44 , 50 ].…”

“…Finally, LC-MS was used to quantify the relative concentration of metabolites/chemicals based on intense peaks of mass spectra. However, the approach is affected by ion suppression of the co-eluting compounds, and the peak areas may not accurately represent the absolute metabolite concentration [ 52 ]. Therefore, we could not assess whether these chemicals exceeded the health regulation levels (GHS classification).…”