Pelargonidin improves memory deficit in amyloid β25-35 rat model of Alzheimer’s disease by inhibition of glial activation, cholinesterase, and oxidative stress

Sohanaki, Hamid; Baluchnejadmojarad, Tourandokht; Nikbakht, Farnaz; Roghani, Mehrdad

doi:10.1016/j.biopha.2016.06.021

Cited by 66 publications

(26 citation statements)

References 52 publications

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“…doses (3, 10, 30 mg/kg) vs. high doses (200 and 400 mg/kg) (6). Bilateral intrahippocampal injections of aggregated Aβ25-35 have shown to produce MWM performance deficit (9,14). In the present study, escape latency and distance swum showed a comparable increase till the fourth training day and reached the level of "only TP-treated" (control) animals.…”

Section: Discussionsupporting

confidence: 60%

Low Dose Teucrium Polium Hydro-Alcoholic Extract Treatment Effects on Spatial Memory and Hippocampal Neuronal Count of Rat Aβ25-35 Model of Alzheimer’s Disease

Ghasemi¹,

Sohanaki²,

Keshavarz³

et al. 2019

Arch Neurosci

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Alzheimer's disease (AD) is a multifactorial and debilitating condition without precise etiology and definite cure burdened with high monetary and human resources to the society around the globe. Given that Iranian traditional medicine has a valuable treasure of medicinal plants with multi-dimensional effects, we designed this study to examine one week daily low single-dose treatment protocol of 3 mg/kg Teucrium polium (TP) hydro-alcoholic extract effects on rat's spatial memory performance and CA1 hippocampal neuronal count in rat Aβ25-35 as an AD model. Animals were bilaterally microinjected with single 10 µg/2 µg intrahippocampal Aβ25-35 fragment for the AD induction. After a two-week recovery period, daily intraperitoneal injection of TP for a week was initiated in Aβ-received TP-treated (treated) and TP-received animals (control). Spatial memory performance and CA1 neuronal count were evaluated. TP significantly reduced time latency and distance swum during the first three days of the training protocol compared with Aβ-received rats (sham). Probe reference test findings, however, were not statistically different in treated, sham, and control groups. Intact CA1 hippocampal neuronal count showed a significant increase in Aβ-received TP-treated (case) rats in comparison with Aβ-received (sham) animals. It seems that the least reported low dose TP has the active chemical components capable of memory enhancing effects in Morris water maze (MWM) setting and potential neuronal survival property in hippocampal tissue. In spite of myriad claims against TP use, we should reconsider the matter and do more research to find the exact active ingredients of various species of the plant plus possible underlying mechanisms for ensuring potential use for human clinical trials in AD and other central nervous system-related diseases.

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Section: Discussionsupporting

confidence: 60%

Low Dose Teucrium Polium Hydro-Alcoholic Extract Treatment Effects on Spatial Memory and Hippocampal Neuronal Count of Rat Aβ25-35 Model of Alzheimer’s Disease

Ghasemi¹,

Sohanaki²,

Keshavarz³

et al. 2019

Arch Neurosci

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“…Pelargonidin is the most abundant anthocyanidin found in strawberries. Administration of pelargonidin in an Alzheimer's disease rodent model demonstrated improvement in memory deficit and reduction in hippocampal oxidative stress [42]. It has been shown that various bioactives present in strawberries are absorbed, extensively metabolized, and circulated in the plasma of older adults [43].…”

Section: Discussionmentioning

confidence: 99%

Association of Strawberries and Anthocyanidin Intake with Alzheimer’s Dementia Risk

et al. 2019

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Background: Strawberries have been identified to have antioxidant and anti-inflammatory properties that improve neuronal function and cognition, mostly in animal studies. It is unknown if the consumption of strawberries or related bioactives may reduce the risk of Alzheimer’s dementia risk. Material and Methods: The study was conducted in 925 participants, aged 58–98 years of the Rush Memory and Aging Project. Participants were dementia-free at baseline, completed a food frequency questionnaire, and had at least two annual neurological evaluations. The diagnosis of Alzheimer’s dementia was based on structured clinical neurological examination and standardized diagnostic criteria. The association of strawberry intake and incident Alzheimer’s dementia was analyzed using proportional hazard models adjusted for age, sex, education, physical activity, participation in cognitive activities, APOE-ɛ4 genotype, dietary intake of other fruits, and total calorie intake. Results: A total of 245 participants developed Alzheimer’s dementia over the mean follow-up of 6.7 (±3.6) years. Higher strawberry intake was associated with reduced risk of Alzheimer’s dementia (HR = 0.76, 95% CI: 0.60–0.96). In separate adjusted models, highest vs. lowest quartile intakes of Vitamin C (HR = 0.64, 95% CI: 0.45, 0.92), Pelargonidin (0.63, 95% CI: 0.43, 0.92), total anthocyanidins (0.69, 95% CI: 0.48, 0.99), and total flavonoids (0.67, 95% CI: 0.46, 0.98) were each associated with lower Alzheimer’s dementia risk. These associations remained after further adjustment for cardiovascular conditions. Conclusion: Consumption of strawberries and foods rich in vitamin C, pelargonidin, anthocyanidins, and total flavonoids may reduce the risk of Alzheimer’s dementia.

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“…Many experiments have demonstrated that Aβ 25–35 can induce neurotoxicity and AD-like pathology, such as activating glial cells, increasing cholinesterase expression [30] and oxidative stress [31], as well as impairing spatial learning and memory [32,33]. Our previous study also showed that Aβ 25–35 could result in neuroinflammatory response and dysfunction of neurotrophin system [34].…”

Section: Discussionmentioning

confidence: 99%

An Extract from Shrimp Processing By-Products Protects SH-SY5Y Cells from Neurotoxicity Induced by Aβ25–35

et al. 2017

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Increased evidence suggests that marine unsaturated fatty acids (FAs) can protect neurons from amyloid-β (Aβ)-induced neurodegeneration. Nuclear magnetic resonance (NMR), high performance liquid chromatography (HPLC) and gas chromatography (GC) assays showed that the acetone extract 4-2A obtained from shrimp Pandalus borealis industry processing wastes contained 67.19% monounsaturated FAs and 16.84% polyunsaturated FAs. The present study evaluated the anti-oxidative and anti-inflammatory effects of 4-2A in Aβ25–35-insulted differentiated SH-SY5Y cells. Cell viability and cytotoxicity were measured by using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assays. Quantitative PCR and Western blotting were used to study the expression of neurotrophins, pro-inflammatory cytokines and apoptosis-related genes. Administration of 20 μM Aβ25–35 significantly reduced SH-SY5Y cell viability, the expression of nerve growth factor (NGF) and its tyrosine kinase TrkA receptor, as well as the level of glutathione, while increased reactive oxygen species (ROS), nitric oxide, tumor necrosis factor (TNF)-α, brain derived neurotrophic factor (BDNF) and its TrkB receptor. Aβ25–35 also increased the Bax/Bcl-2 ratio and Caspase-3 expression. Treatment with 4-2A significantly attenuated the Aβ25–35-induced changes in cell viability, ROS, GSH, NGF, TrkA, TNF-α, the Bax/Bcl-2 ratio and Caspase-3, except for nitric oxide, BDNF and TrKB. In conclusion, 4-2A effectively protected SH-SY5Y cells against Aβ-induced neuronal apoptosis/death by suppressing inflammation and oxidative stress and up-regulating NGF and TrKA expression.

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Pelargonidin improves memory deficit in amyloid β25-35 rat model of Alzheimer’s disease by inhibition of glial activation, cholinesterase, and oxidative stress

Cited by 66 publications

References 52 publications

Low Dose Teucrium Polium Hydro-Alcoholic Extract Treatment Effects on Spatial Memory and Hippocampal Neuronal Count of Rat Aβ25-35 Model of Alzheimer’s Disease

Low Dose Teucrium Polium Hydro-Alcoholic Extract Treatment Effects on Spatial Memory and Hippocampal Neuronal Count of Rat Aβ25-35 Model of Alzheimer’s Disease

Association of Strawberries and Anthocyanidin Intake with Alzheimer’s Dementia Risk

An Extract from Shrimp Processing By-Products Protects SH-SY5Y Cells from Neurotoxicity Induced by Aβ25–35

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