Peliosis Hepatis After Long-Term Administration of Oxymetholone

Peliosis Hepatis Associated with Liver and Retroperitoneal Abscesses

“…Pe liosis might result from post-or intrasinusoidal blockade [14], a direct drug-induced in jury to the endothelial lining cells [8] or destruction of the other elements of the sinu soidal skeleton including the reticulin fibre network and the adjacent hepatocytes [8], Rupture of the walls of the sinusoids, the central vein or the terminal venules are also possible [4], Although venous angiopathy and local disturbances in the microcircula tion [11] may be responsible, it seems un likely that venous congestion of the liver as a single factor may lead to peliosis [7]. In rat experiments a role of the reticulo-endothelial system has also been suggested [5].…”

“…That androgenic-anabolic ste roids may cause peliosis now seems very likely [1,3,4,8,11], The gestagenic compo nent of oral contraceptives has also been accused [4], but the association is less clear [3], Peliosis has also been described with the use of radio-and chemotherapy and the combination of prednisone and azathioprine as immune-suppressive agents [3]. Okuda [9] described peliosis as a complication of liver disease induced by thorotrast.…”

“…Regression on a clinical basis or by con trol biopsy is very rare [1,4,6], so therapeu tical guidelines are difficult to suggest. In drug-induced cases the offending drug should be withdrawn and regression has been described [1,4], In cases of infection or malignancy the underlying disorder should be treated.…”

“…In drug-induced cases the offending drug should be withdrawn and regression has been described [1,4], In cases of infection or malignancy the underlying disorder should be treated. In our case external and internal drainage of the abscesses resulted in definite improvement of the patient's condition.…”

Hepatocellular carcinoma in a young woman with prolonged exposure to oral contraceptives

“…His conclusions of mestranol's importance have recently been questioned, since there was not an adequate sampling of contraceptives containing ethinyl estradiol(27). tives, Gross et al (28) suggested that the progestational agents derived from 19-nortestoterone have androgenic activity and thus are highly suspect. Modulation of the androgenic activity by the estrogenic component may be a complex interaction yielding a final end-Laboratory data, obtained from mice strains with a high likelihood of developing…”