Peliosis hepatis with initial presentation as acute hepatic failure and intraperitoneal hemorrhage in children

Jacquemin, Emmanuel; Pariente, D.; Fabrè, Monique; Huault, G; Valayer, J; Bernard, Olivier

doi:10.1016/s0168-8278(99)80271-2

Cited by 40 publications

(21 citation statements)

References 12 publications

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“…b T2-weighted image. The lesion is composed of small hyperintense "cystic" areas interspersed with hypointense borders tant, complication [14,15,16,17]. Superselective embolization of the hepatic artery has been reported to be successful in the treatment of intrahepatic bleeding due to peliosis [17].…”

Section: Casementioning

confidence: 99%

Peliosis hepatis presenting as a multifocal hepatic pseudotumor: MR findings in two cases

et al. 2003

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Two cases of pseudotumoral peliosis hepatis are presented with emphasis on MRI findings. One patient had four individual lesions, the other had two. Image characteristics in both were: heterogeneic signal intensity on T1-weighted images (T1WI) with areas of high-, intermediate, and low signal intensity; heterogeneic signal intensity on T2WI with presence of numerous intralesional "cystic" hyperintense areas with a hypointense border. Signal intensities on T1WI were iso- to hypointense in one case and mild central hyperintensities were demonstrated in the other case, probably due to intra-lesional hemorrhage or diffuse accumulation of fresh clotting within the sinusoids. One case demonstrated early enhancement of the peripheral borders in the arterial phase, and both demonstrated enhancement in the portovenous and late phases. One case was studied with Gd-BOPTA and iron oxides and demonstrated enhancement with both products, suggestive for the presence of hepatocytes and Kupffer cells. This is the first report of the use of hepato-specific contrast agents in this entity. Spontaneous regression of the lesions was demonstrated on a follow-up MR examination in one case.

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Section: Casementioning

confidence: 99%

Peliosis hepatis presenting as a multifocal hepatic pseudotumor: MR findings in two cases

et al. 2003

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“…Reports have described outcomes ranging from spontaneous resolution to hepatic failure or fatal intraperitoneal hemorrhage. Some reports have described the resolution of PH after withdrawal of causative drugs or after treatment of the associated conditions [12,26,27] . In other reports, patients presenting in fulminant hepatic failure eventually died.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous liver rupture in a patient with peliosis hepatis:A case report

Choi¹,

Jin²,

Cho³

et al. 2009

WJG

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Peliosis hepatis is a rare pathological entity and may cause fatal hepatic hemorrhage and liver failure. Here, we present a young male patient with aplastic anemia, who had received long-term treatment with oxymetholone. The patient suffered from sudden onset of intra-abdominal hemorrhage with profuse hemoperitoneum. The patient was treated successfully with a right hemihepatectomy and is in good health after 13 postoperative months. We suggest that peliosis hepatis be considered in patients with hepatic parenchymal hematoma, especially in patients under prolonged synthetic anabolic steroid medication. The possibility of a potentially life-threatening complication of massive intra-abdominal bleeding should also be considered.

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“…15 Proliferation of endothelial cells in turn can be triggered by angiogenetic factors; Bartonella is thought to be relatively unique among bacteria in inducing such factors. 14,17,18 Differential diagnosis can prove to be a difficult task: haemangiomas, hepatic abscesses, haematomas, and primary or metastatic tumours, as well as secondary hepatic congestion due to veno-occlusive disease or the Budd-Chiari syndrome 19,20 need to be ruled out. The CT appearance of hepatic peliosis can range from no visible abnormality, to multiple lesions of varying sizes and attenuation.…”

Section: Discussionmentioning

confidence: 99%

Peliosis Hepatis following treatment with androgen-steroids in patients with bone marrow failure syndromes

Tsirigotis¹,

Sella²,

Shapira³

et al. 2007

Haematologica

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Peliosis hepatis with initial presentation as acute hepatic failure and intraperitoneal hemorrhage in children

Cited by 40 publications

References 12 publications

Peliosis hepatis presenting as a multifocal hepatic pseudotumor: MR findings in two cases

Peliosis hepatis presenting as a multifocal hepatic pseudotumor: MR findings in two cases

Spontaneous liver rupture in a patient with peliosis hepatis:A case report

Peliosis Hepatis following treatment with androgen-steroids in patients with bone marrow failure syndromes

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