Peliosis of the female adrenal cortex of the aging rat

Dual Effects of Prolonged ACTH Stimulation on 4-Hydroxyaminoquinoline 1-Oxide-Induced Adrenocortical Lesions in Rats

“…Comparison of the incidence of peliotic lesions in the adrenal cortex at the different time points clearly demonstrated that a single sc injection of 4HAQO can induce their development, while ACTH suppresses it. Although it has been shown that peliosis of the zona fasciculata occurs spontaneously in aged female rats (6,22), in this case no accompanying degenerative alteration of adrenocortical cells has been described (6). In 4HAQO-induced adrenal peliosis in rats observed in the present study, peliotic alterations were always associated with degeneration of the parenchyma of the adrenocortex.…”

“…(6,22), in this case no accompanying degenerative alteration of adrenocortical cells has been described (6). In 4HAQO-induced adrenal peliosis in rats observed in the present study, peliotic alterations were always associated with degeneration of the parenchyma of the adrenocortex.…”

“…4-Hydroxyaminoquinoline 1-oxide (4HAQO), an intermediate metabolite and possible proximate carcinogenic form of 4-nitroquinoline 1-oxide (12), is both toxic and carcinogenic to organs such as the pancreas and lung in rodents (9,20). Recently, we have established that a single intravenous injection of 4HAQO to female Sprague-Dawley rats results in the development of adrenocortical cystic degeneration, which mimics an ageassociated degenerative change, namely, adrenal peliosis (6). In old female rats, adrenal peliosis of the zona fasciculata occurs spontaneously at a high incidence (6,22).…”

“…Recently, we have established that a single intravenous injection of 4HAQO to female Sprague-Dawley rats results in the development of adrenocortical cystic degeneration, which mimics an ageassociated degenerative change, namely, adrenal peliosis (6). In old female rats, adrenal peliosis of the zona fasciculata occurs spontaneously at a high incidence (6,22). It is also found in mice transplanted with ovarian granulosa cell tumors (8).…”

Distinguishing Cystic Degeneration from Other Aging Lesions in the Adrenal Cortex of Sprague-Dawley Rats

“…The lesion is more common in Sprague-Dawley (SD) rats than Fischer 344 (F344) rats. Congestion and/or hemorrhage are common features, leading to the use of the term peliosis (Dhom et al 1981); however, more recently cystic degeneration is considered the preferred terminology. The lesion is more common in female rats and the incidence increases in male rats treated with estrogens (Gopinath, Prentice, and Lewis 1987).…”