Pellagra: A forgotten ailment in current clinical practice

Harsha, NS; B, Suraj; Kanakavidu, Supreeth S; Kodali, Ramyasri

doi:10.4103/mjdrdypu.mjdrdypu_62_18

Cited by 4 publications

(1 citation statement)

References 1 publication

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“…It associates a photo-induced skin rash, transit disorders, and in case of prolonged deficiency, neurological signs. The most common etiology is lack of intake, but other causes may be involved [1]. Here we report a case of A 110-year-old woman with pellagra.…”

Section: Introductionmentioning

confidence: 90%

A photo-distributed rash with neurological problems in an elderly man: Don’t forget pellagra!

Dahhouki¹,

Alaoui²,

Issoual³

2020

Our Dermatol Online

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Pellagra is caused by deficiency of niacin or its amino acid precursor tryptophan. Clinical features are characterized by dermatitis, dementia and diarrhea. Dermatitis is observed only in 33% of patients. We report a 110-year-old woman, with history of diarrhea and dementia, who presented a bilateral and symmetrical dermatosis, characterized by welldemarcated violaceous plaques due to sun exposition. Dermatological symptoms had directed investigations. Pellagra was diagnosed and treatment with supplement and oral niacin was started, with significant improvement.

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Section: Introductionmentioning

confidence: 90%

A photo-distributed rash with neurological problems in an elderly man: Don’t forget pellagra!

Dahhouki¹,

Alaoui²,

Issoual³

2020

Our Dermatol Online

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Is nuclear sirtuin SIRT6 a master regulator of immune function?

Pillai

Gupta

2021

American Journal of Physiology-Endocrinology and Metabolism

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The ability to ward off pathogens with minimal damage to the host determines the immune system's robustness. Multiple factors, including pathogen processing, identification, secretion of mediator and effector molecules, and immune cell proliferation and differentiation into various subsets, constitute the success of mounting an effective immune response. Cellular metabolism controls all of these intricate processes. Cells utilize diverse fuel sources and switch back and forth between different metabolic pathways depending on their energy needs. The three most critical metabolic pathways on which immune cells depend to meet their energy needs are oxidative metabolism, glycolysis, and glutaminolysis. Dynamic switching between these metabolic pathways is needed for optimal function of the immune cells. Moreover, switching between these metabolic pathways needs to be tightly regulated to achieve the best results. Immune cells depend on the Warburg effect for their growth, proliferation, secretory, and effector functions. Here, we hypothesize that the sirtuin, SIRT6, could be a negative regulator of the Warburg effect. We also postulate that SIRT6 could act as a master regulator of immune cell metabolism and function by regulating critical signaling pathways.

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Prevalence, knowledge, awareness, and attitudes towards dietary supplements among Bahraini adults: a cross-sectional study

Allehdan,

Hasan,

Perna

et al. 2023

Food Prod Process and Nutr

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The usage of dietary supplements (DS) is a global trend that is likely influenced by sociodemographic variables and body weight status. Some individuals utilize supplements in the hopes that they may enhance their health and prevent illness. Main objective of this study is to assess knowledge and awareness about using DS among Bahraini adults. This cross-sectional study was conducted using snowball sampling method, in which an electronic self-administrative questionnaire was used to collect information from 582 eligible participants. Data about socio-demographic characteristics, anthropometric measurements, knowledge, awareness, and attitudes toward using DS was collected from each participant. Prevalence of DS use was high (59.3%) and most of users were females. Most DS users (87.5%) thought that DS are safe (P < 0.001). The DS users were significantly more likely than non-users to believe that DS can prevent and treat chronic and communicable diseases, as well as the DS having side effects (P < 0.05). The most frequently consumed DS were vitamin D (29.5%) and vitamin C (26.4%). The main purpose of using DS among the DS users was to treat nutrient deficiency and around 60% of them used DS based on physician’s prescription. In conclusion, the using of DS was highly prevalent among younger adult females with normal body weight. The findings of this study emphasize the need for implementing public educational programs about safe and proper use of DS. Graphical Abstract

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Pellagra: A forgotten ailment in current clinical practice

Cited by 4 publications

References 1 publication

A photo-distributed rash with neurological problems in an elderly man: Don’t forget pellagra!

A photo-distributed rash with neurological problems in an elderly man: Don’t forget pellagra!

Is nuclear sirtuin SIRT6 a master regulator of immune function?

Prevalence, knowledge, awareness, and attitudes towards dietary supplements among Bahraini adults: a cross-sectional study

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