Pellagre : aux grands maux les petits remèdes

Kort, Y.; Aloui, Adel; Khammassi, N.; Abdelhedi, H.; Cherif, O.

doi:10.1016/j.revmed.2014.10.331

Cited by 1 publication

(3 citation statements)

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“…S. Lescuyer and al estimate that Gayet Wernicke’s Encephalopathy is under-diagnosed, with a clinical prevalence of 0.04% to 0.13% compared to 0.8% and 2.8% in pathology [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…The evolution is marked by the disappearance of clinical signs and MRI images if treatment is started early. However, in the event of a delay in diagnosis or treatment, the progression is towards neurological sequelae such as Korsakoff’s syndrome (atrophy of the mammary bodies) or even death in 17% of cases [ 5 , 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Initially reported in malnourished alcoholic patients, this condition can be seen in any situation causing severe undernutrition, including hyperemesis gravidarum, thyrotoxicosis, peptic ulcer and stomach cancer, duodenal or jejunal resection, bariatric surgery, anorexia nervosa, prolonged fasting, and prolonged parenteral nutrition [5][6][7][8][9].…”

Section: Discussionmentioning

confidence: 99%

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Gayet-Wernicke’s encephalopathy complicating prolonged parenteral nutrition in patient treated for colonic cancer – a case report –

et al. 2022

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Background Gayet-Wernicke’s encephalopathy (GWE) is a neurological pathology caused by a Thiamine deficiency. While it is most often related to chronic alcoholism, GWE can occur in any situation that results in thiamine deficiency. It is a fairly common pathology that is frequently underdiagnosed and therefore under-treated, and is associated with a high mortality and morbidity rate. In the absence of pathognomonic signs, the diagnosis of GWE relies on a range of clinical, biological and radiological assessments. GWE is considered a medical emergency. We present a case of Gayet-Wernicke’s Encephalopathy resulting from complete parenteral nutrition in an undernourished North African male operated for a left colon tumor. Through this report, our aim was to put the light on this often underknown disease and to remind the interest of thinking about this pathology in patients at risk of undernourishment especially in oncology. Case presentation A 66-year-old North African male with no personal or family history was operated for a sigmoid colon tumor. He was put on exclusive parenteral nutrition on day thirteen post-operatively and presented with a GWE on day sixteen post-operatively. The patient was treated with intravenous vitamin B1 on day eighteen post-operatively and deceased on day twenty-four post-operatively. Conclusions Although most often associated with chronic alcoholism, GWE occurs in any situation where there is an increased energy demand or decreased nutritional intake especially in oncology. GWE is common but under-diagnosed and remains lethal if not treated urgently, hence the importance of prophylactic treatment.

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“…S. Lescuyer and al estimate that Gayet Wernicke’s Encephalopathy is under-diagnosed, with a clinical prevalence of 0.04% to 0.13% compared to 0.8% and 2.8% in pathology [ 5 ].…”

Section: Discussionmentioning

confidence: 99%