Pelletization by Extrusion Spheronization Technique: An Excipient Review

Jadhav, Namdeo; Irny, Preeti; Mokashi, Ashwini; Souche, Pravin; Paradkar, Anant

doi:10.2174/2210304x11202020132

Cited by 2 publications

(2 citation statements)

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“…Since 1970, extrusion spheronization has been one of the most prevalent procedures for preparing pellets for the acquisition of modified release systems in the pharmaceutical sector. 8 Extrusion spheronization pellets provide multiple benefits, including high sphericity, dense structure, less hygroscopic product, limited particle size distribution, and a plane and even surface. 9,10 The number of persons diagnosed with diabetes has risen dramatically during the last two decades all across the world.…”

Section: Introductionmentioning

confidence: 99%

Impact of Selective Polymer on Optimization of Sustained Release Matrix Pellets of Sitagliptin

Gurjar¹,

Bhosale²

2023

J. Young Pharm.

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Background:The main goal of any drug delivery system is to achieve the desired concentration of the drug in blood or tissue, which is therapeutically effective and nontoxic for a prolonged period. Sitagliptin is a dipeptidyl peptidase 4 enzyme inhibitor used in the treatment of non-insulin-dependent diabetes mellitus. The purpose of this study was to design a flexible dosage form that controls the release and provides therapeutic effects with minimum side effects. Materials and Methods: Various batches of pellets were made using the extrusion spheronization technique for obtaining the batch that resulted in a sustained release pattern for Sitagliptin. Results: The pellets showed excellent flow properties due to sphericity thereby influencing the dosage production rate, the small particle that could easily disperse and help in avoiding the dose dumping. The pellets showed 89.10 % release in 12 hr. Conclusion: The study concludes the development of sustained-release pellets by selective excipients with better drug release minimizing the problems.

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Section: Introductionmentioning

confidence: 99%

Impact of Selective Polymer on Optimization of Sustained Release Matrix Pellets of Sitagliptin

Gurjar¹,

Bhosale²

2023

J. Young Pharm.

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“…The advantages of the extrusion-spheronization in comparison with other methods are [6,7]:…”

Section: Introductionmentioning

confidence: 99%

Manufacture of Spherical Granules of Isosorbide Dinitrate With Modified Release

Oliinykov

Kaplaushenko

Trehub

et al. 2020

Ankara Universitesi Eczacilik Fakultesi Dergisi

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Objective: This study was aimed to obtain spherical matrix pellets of isosorbide dinitrate with different dissolution kinetics to create a multidosage medicinal form with controlled release of the active substance.Material and Method: Spherical matrix granules were obtained by extrusion-spherinization and coated with different amounts of polymer shell. Dissolution profiles of the obtained spheroids were compared with reference drug tablets.Result and Discussion: The results showed that the combination of spherical granules provides an isosorbide dinitrate release profile similar to the dissolution of Cardicet Retard tablets. The target dissolution profile is achieved using a combination of uncoated spherical granules and spheroids with a 10% film coating. The similarity coefficient (f2) is 73.6.

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Pelletization by Extrusion Spheronization Technique: An Excipient Review

Cited by 2 publications

References 0 publications

Impact of Selective Polymer on Optimization of Sustained Release Matrix Pellets of Sitagliptin

Impact of Selective Polymer on Optimization of Sustained Release Matrix Pellets of Sitagliptin

Manufacture of Spherical Granules of Isosorbide Dinitrate With Modified Release

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