To study the influence of process parameter changes on the properties of raw material obtained from corn rind, a central composite design (CCD) methodology with four factors and five levels was applied to statistically optimize the parameters. The stalk size, soaking time, working temperature, and processing speed were selected as influencing factors. The available fiber ratio, initial beating degree, and fiber aspect ratio were chosen as indicators. Response surface analysis methodology was employed for optimization. The results showed that the optimal range of parameters were as follows: 8 to 13 cm for the stalk size, 18 h for the soaking time, 60 °C for the working temperature, and 98 to 112 r·min-1 for the processing speed. In this optimal condition, the available fiber ratio was higher than 95%, initial beating degree was greater than 11 °SR, and fiber aspect ratio was greater than 50. The results could be applied to design and optimize the D200 type stalk fiber preparation machine and the process of making raw material.