Peltophorum dubium and soybean Kunitz-type trypsin inhibitors induce human Jurkat cell apoptosis

Troncoso, María F.; Biron, Verónica A.; Longhi, Silvia Andrea; Retegui, Lilia A.; Wolfenstein‐Todel, Carlota

doi:10.1016/j.intimp.2007.01.002

Cited by 20 publications

(18 citation statements)

References 43 publications

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“…Many findings reported about the anti-proliferative effect and apoptosis in human leukemia cells (JURKAT) via PDTI and SBTI activity. In addition, human peripheral lymphocytes, stimulated with phytohemagglutinin or not, are also sensitive to viability decrease that is induced by SBTI (Troncoso et al, 2007). …”

Section: Roles Of Plant Protease Inhibitors In Health and Disease Conmentioning

confidence: 99%

Plant Protease Inhibitors in Therapeutics-Focus on Cancer Therapy

2016

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Plants are known to have many secondary metabolites and phytochemical compounds which are highly explored at biochemical and molecular genetics level and exploited enormously in the human health care sector. However, there are other less explored small molecular weight proteins, which inhibit proteases/proteinases. Plants are good sources of protease inhibitors (PIs) which protect them against diseases, insects, pests, and herbivores. In the past, proteinaceous PIs were considered primarily as protein-degrading enzymes. Nevertheless, this view has significantly changed and PIs are now treated as very important signaling molecules in many biological activities such as inflammation, apoptosis, blood clotting and hormone processing. In recent years, PIs have been examined extensively as therapeutic agents, primarily to deal with various human cancers. Interestingly, many plant-based PIs are also found to be effective against cardiovascular diseases, osteoporosis, inflammatory diseases and neurological disorders. Several plant PIs are under further evaluation in in vitro clinical trials. Among all types of PIs, Bowman-Birk inhibitors (BBI) have been studied extensively in the treatment of many diseases, especially in the field of cancer prevention. So far, crops such as beans, potatoes, barley, squash, millet, wheat, buckwheat, groundnut, chickpea, pigeonpea, corn, and pineapple have been identified as good sources of PIs. The PI content of such foods has a significant influence on human health disorders, particularly in the regions where people mostly depend on these kind of foods. These natural PIs vary in concentration, protease specificity, heat stability, and sometimes several PIs may be present in the same species or tissue. However, it is important to carry out individual studies to identify the potential effects of each PI on human health. PIs in plants make them incredible sources to determine novel PIs with specific pharmacological and therapeutic effects due to their peculiarity and superabundance.

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Section: Roles Of Plant Protease Inhibitors In Health and Disease Conmentioning

confidence: 99%

Plant Protease Inhibitors in Therapeutics-Focus on Cancer Therapy

2016

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“…Similarly, trypsin inhibitors extracted from Peltophorum dubium seeds, as well as from soy beans, also were shown to induce apoptosis in rat lymphoma cells and also in human leukemia Jurkat cells. 110 It has been demonstrated that resveratrol induced apoptosis in Hodgkin's lymphoma-derived L-428 cells in a dose-dependent manner. At lower concentrations, resveratrol caused cell cycle arrest in the S phase, while at higher concentrations, it induced apoptosis activating caspase 3.…”

Section: Anticancer Properties Of Fruits and Vegetables Potentially Ementioning

confidence: 99%

Cancer Preventive and Therapeutic Properties of Fruits and Vegetables Against Commonly Occurring Cancers in Humans

Monisha¹,

Bakliwal²,

Katre³

et al. 2015

Anticancer Properties of Fruits and Vegetables

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“…Investigações fitoquímicas demonstraram que as cascas caulinares possuem entre 6 e 8% de taninos (REITZ, KLEIN, REIS, 1978) e as folhas contêm saponinas (MAYWORM, SALATINO, BUCKERIDGE, 2004). Das sementes, obtém-se um inibidor da tripsina capaz de induzir apoptose em células de leucemia, atividade com perspectiva de aplicação no tratamento de diferentes tipos de câncer (TRONCOSO et al, 2007).Em razão desse potencial terapêutico, este estudo procurou contribuir no conhecimento de P. dubium, ao investigar a morfoanatomia de folha e caule para a caracterização dessa planta medicinal e a diagnose dessa promissora droga vegetal. …”

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MORPHO-ANATOMICAL DIAGNOSIS OF CANAFÍSTULA: Peltophorum dubium (SPRENG.) TAUB. (FABACEAE)

Duarte

Krentkowski

2014

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RESUMO:A espécie Peltophorum dubium, nativa da América do Sul, está circunscrita em Caesalpinioideae/Fabaceae. Conhecida como canafístula, é empregada na terapêutica popular brasileira como anti-inflamatório e anti-infeccioso. Este estudo investigou a morfoanatomia foliar e caulinar para contribuir na caracterização dessa planta medicinal. Diferentes partes de folhas adultas (pecíolo, raque, folíolo, peciólulo e foliólulo), como também fragmentos de caules jovens foram fixados, seccionados e corados para análise em microscopia de luz. Testes microquímicos e microscopia eletrônica de varredura também foram realizados. As folhas são paribipinadas e os foliólulos mostram tricomas tectores pluricelulares, epiderme unisseriada recoberta por cutícula lisa e plaquetas de cera epicuticular, estômatos anomocíticos em ambas as superfícies foliares, mesofilo dorsiventral e um único feixe vascular colateral em arco aberto na nervura central. O feixe vascular é em arco fechado no peciólulo e em arranjo circular na raque e no pecíolo. O caule revela estrutura secundária incipiente com epiderme persistente. Há uma bainha esclerenquimática conspícua circundando o cilindro floemático que é externo ao xilemático. Ocorrem compostos fenólicos, mucilagem e cristais prismáticos de oxalato de cálcio. Palavras-chave: Caesalpinioideae, farmacognosia, Leguminosae, planta medicinal ABSTRACT:The species Peltophorum dubium, native to South America, is circumscribed to Caesalpinioideae/Fabaceae. Popularly known as canafístula in Portuguese, it is used in the Brazilian folk medicine as anti-inflammatory and antimicrobial. This study has investigated the leaf and stem morpho-anatomy to contribute for the characterization of this medicinal plant. Different parts of adult leaves (petiole, rachis, leaflet, petiolule and twice-pinnate leaflet) as well as fragments of young stems were fixed, sectioned and stained for light microscopic analyses. Microchemical tests and scanning electron microscopy were also performed. The leaves are even bipinnate and the twice-pinnate leaflets have shown multicellular non-glandular trichomes, uniseriate epidermis coated with smooth cuticle and platelets of epicuticular wax, anomocytic stomata on both epidermal sides, dorsiventral mesophyll and one single collateral vascular bundle in open arc in the midrib. The vascular bundle is in closed arc in the petiolule, and circular in the rachis and petiole. The stem displays incipient secondary development and remaining epidermis. There is a conspicuous sclerenchymatic sheath encircling the phloem cylinder which is external to the xylem. It is encountered phenolic compounds, mucilage and prisms of calcium oxalate. Keywords: Caesalpinioideae, Leguminosae, medicinal plant, pharmacognosy INTRODUÇÃOA espécie Peltophorum dubium (Spreng.) Taub., anteriormente referida pelo basiônimo Caesalpinia dubia Spreng. e pela sinonímia Cassia disperma Vell. e Peltophorum vogelianum Benth., entre outras denominações (MOBOT, 2014; PLANT LIST, 2014), está circunscrita à subfamília Caesalpin...

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Peltophorum dubium and soybean Kunitz-type trypsin inhibitors induce human Jurkat cell apoptosis

Cited by 20 publications

References 43 publications

Plant Protease Inhibitors in Therapeutics-Focus on Cancer Therapy

Plant Protease Inhibitors in Therapeutics-Focus on Cancer Therapy

Cancer Preventive and Therapeutic Properties of Fruits and Vegetables Against Commonly Occurring Cancers in Humans

MORPHO-ANATOMICAL DIAGNOSIS OF CANAFÍSTULA: Peltophorum dubium (SPRENG.) TAUB. (FABACEAE)

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