Pelvic applications of MR-guided high intensity focused ultrasound

Coakley, Fergus V.; Foster, Bryan R.; Farsad, Khashayar; Hung, Arthur; Wilder, Kathleen J.; Amling, Christopher L.; Caughey, Aaron B.

doi:10.1007/s00261-013-9999-2

Cited by 15 publications

(20 citation statements)

References 67 publications

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“…It is understood that coagulative necrosis is achieved when tissue within a focal zone is heated to a threshold temperature of 55°C-85°C. 1 However, 70°C-80°C is an optimal target temperature to ensure real tissue necrosis. 1 While its potential to treat soft tissue tumors in the body was recognized in the middle of the 20th century, HIFU ablation has only recently become a widespread treatment modality.…”

Section: Hifu Ablationmentioning

confidence: 99%

“…1 However, 70°C-80°C is an optimal target temperature to ensure real tissue necrosis. 1 While its potential to treat soft tissue tumors in the body was recognized in the middle of the 20th century, HIFU ablation has only recently become a widespread treatment modality. Previously, a lack of robust methods of monitoring and controlling in real time the thermal tissue damage, and its imprecision had led to markedly variable outcomes and to concerns over safety.…”

Section: Hifu Ablationmentioning

confidence: 99%

“…It is defined as the ectopic presence of endometrial glands and stroma within the uterine myometrium, with resultant reactive smooth muscle hypertrophy. 1,2 Several pathological patterns exist. In some cases, there may be minimal hypertrophy of the uterus with microscopically detectable small infiltrates, confirmed only following hysterectomy.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

MR-guided focused ultrasound for the treatment of adenomyosis: current insights

Chin¹,

Walbridge²,

Quinn³

2015

RRFU

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Adenomyosis is a benign gynecological condition causing significant morbidity among women of reproductive age. The available treatments are currently limited in number and efficacy. While hysterectomy is curative, it is unacceptable to many women, particularly those wishing to conserve their fertility. Magnetic resonance-guided focused ultrasound surgery is a noninvasive treatment method that has been used to effectively treat uterine leiomyomata, but until recently has not been routinely used to treat adenomyosis. This review summarizes the current understanding of adenomyosis and high-intensity focused ultrasound, and the recent research into the safety and efficacy of this technique.

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Section: Hifu Ablationmentioning

confidence: 99%

Section: Hifu Ablationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

MR-guided focused ultrasound for the treatment of adenomyosis: current insights

Chin¹,

Walbridge²,

Quinn³

2015

RRFU

View full text Add to dashboard Cite

show abstract

“…Although requires contact with the targeted lesion, laser induced thermal therapy commonly uses fiber-optic probe, which does not produce large image artifacts caused by electromagnetic interference, as in RFA. The feasibility of performing MR guided high intensity focused ultrasound (MRgHIFU) and MR guided laserinduced thermal therapy (MRgLITT) has been established and further demonstrated by treating tumors in brain (27,(36)(37)(38)(39), prostate (40,41), and liver (30,42,43).…”

Section: Current Mr-guided Tumor Ablation Techniquesmentioning

confidence: 99%

Image-guided thermal ablation with MR-based thermometry

Zhu

Sun

2017

Quant. Imaging Med. Surg.

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Thermal ablation techniques such as radiofrequency, microwave, high intensity focused ultrasound (HIFU) and laser have been used as minimally invasive strategies for the treatment of variety of cancers. MR thermometry methods are readily available for monitoring thermal distribution and deposition in real time, leading to decrease of incidents of normal tissue damage around targeted lesion. HIFU and laser-induced thermal therapy (LITT) are the two widely accepted tumor ablation techniques because of their compatibility with MR systems. MRI provides multiple temperature dependent parameters for thermal imaging, such as signal intensity, T1, T2, diffusion coefficient, magnetization transfer, proton resonance frequency shift (PRFS, including phase imaging and spectroscopy) as well as frequency shift of temperature sensitive contrast agents. Absolute temperature mapping techniques, including both spectroscopic imaging using metabolites as a reference and phase imaging using fat as a reference, are immune to susceptibility effects and are not dependent on phase differences. These techniques are intrinsically more reliable than relative temperature measurement by phase mapping methods. If the limitation of low temporal and spatial resolution could be overcome, these methods may be preferred for MR-guided thermal ablation systems.As of today, the most popular MR thermal imaging method applied in tumor thermal ablation surgery is, however, still PRFS based phase mapping technique, which only provides relative temperature change and is prone to motion artifacts.

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“…For true 3D thermal imaging deep in the body MRI techniques seem to have the best potential for clinical use[5-7]. MR-based temperature measurements are successfully applied for thermal ablation[8]. MR-thermometry combined with hyperthermia has been used in monitoring abdominal and pelvic tumour sites[9,10] and has demonstrated good correlation with conventional measurements, which makes it feasible for validating the quality of heating.…”

Section: Introductionmentioning

confidence: 99%

Thermal modelling using discrete vasculature for thermal therapy: A review

Kok

Gellermann

Berg

et al. 2013

International Journal of Hyperthermia

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Reliable temperature information during clinical hyperthermia and thermal ablation is essential for adequate treatment control, but conventional temperature measurements do not provide 3D temperature information. Treatment planning is a very useful tool to improve treatment quality and substantial progress has been made over the last decade. Thermal modelling is a very important and challenging aspect of hyperthermia treatment planning. Various thermal models have been developed for this purpose, with varying complexity. Since blood perfusion is such an important factor in thermal redistribution of energy in in vivo tissue, thermal simulations are most accurately performed by modelling discrete vasculature. This review describes the progress in thermal modelling with discrete vasculature for the purpose of hyperthermia treatment planning and thermal ablation. There has been significant progress in thermal modelling with discrete vasculature. Recent developments have made real-time simulations possible, which can provide feedback during treatment for improved therapy. Future clinical application of thermal modelling with discrete vasculature in hyperthermia treatment planning is expected to further improve treatment quality.

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Pelvic applications of MR-guided high intensity focused ultrasound

Cited by 15 publications

References 67 publications

MR-guided focused ultrasound for the treatment of adenomyosis: current insights

MR-guided focused ultrasound for the treatment of adenomyosis: current insights

Image-guided thermal ablation with MR-based thermometry

Thermal modelling using discrete vasculature for thermal therapy: A review

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