Pelvic endometriosis and natural killer cell immunity

Fukui, Atsushi; Mai, Chuxian; Saeki, Shinichiro; Yamamoto, Mayu; Takeyama, Ryu; Kato, Toru; Ukita, Yuji; Wakimoto, Yu; Yamaya, Ayano; Shibahara, Hiroaki

doi:10.1111/aji.13342

Cited by 35 publications

(22 citation statements)

References 67 publications

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“…This is true for both IL-1α and IL-1β levels, although their effects on endometrial cells differ [74]. Changes in immune cell function in the peritoneal fluid and cytokine production, including IL-1, have been reported to be one cause of infertility [76]. Increased levels of IL-1α are observed in the peritoneal fluid of women with endometriosis.…”

Section: Interleukin 1 (Il-1)mentioning

confidence: 99%

The Role of the Immune System in the Development of Endometriosis

Abramiuk

Grywalska

Małkowska

et al. 2022

Cells

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Endometriosis is a chronic disease that affects about 10% of women of reproductive age. It can contribute to pelvic pain, infertility or other conditions such as asthma, cardiovascular disease, breast or ovarian cancer. Research has shown that one of the conditions for the development of endometrial lesions is the dysfunction of the immune system. It appears that immune cells, such as neutrophils, macrophages, NK cells and dendritic cells, may play a specific role in the angiogenesis, growth and invasion of endometriosis cells. Immune cells secrete cytokines and defensins that also affect the endometriosis environment. This review discusses the various components of the immune system that are involved in the formation of endometrial lesions in women.

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Section: Interleukin 1 (Il-1)mentioning

confidence: 99%

The Role of the Immune System in the Development of Endometriosis

Abramiuk

Grywalska

Małkowska

et al. 2022

Cells

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“…Some studies have shown that the natural receptor for cytotoxicity, NKp46, and the cell surface marker for cytotoxicity, CK107a, are significantly reduced in the peritoneal fluid of patients with endometriosis. In contrast, the NKG2A receptor, an inhibitory cytotoxic receptor, is overexpressed in peritoneal NK cells [57,67,68]. The increase in cytokines in the peritoneal fluid, as well as those secreted by the ectopic endometrial tissue itself, also interfere with the functionality of NK cells.…”

Section: Dysfunction Of the Innate Immune System And Its Relationship...mentioning

confidence: 99%

Endometriosis: A Disease with Few Direct Treatment Options

2022

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Endometriosis is a gynecological condition characterized by the growth of endometrium-like tissues inside and outside the pelvic cavity. The evolution of the disease can lead to infertility in addition to high treatment costs. Currently, available medications are only effective in treating endometriosis-related pain; however, it is not a targeted treatment. The objective of this work is to review the characteristics of the disease, the diagnostic means and treatments available, as well as to discuss new therapeutic options.

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“…Following changes in the properties and function of NK cells, immune surveillance in the peritoneal cavity was impaired, leading to increased survival of EC endometrial cells (Figure 1). 56 Xuan‐Tong Liu et al., suggested that ESCs partly up regulated the expression of IDO in NK cells by secreting TGF‐β, hence reducing the expression of activating receptors and increasing the expression of IL‐ 10 by these cells, and eventually leading to a decrease in the lethal activity of NK cells 57 . The percentage of NK cells in the PB of patients does not differ, but in the case of PF, contradictory results have been reported 58 .…”

Section: Innate Immune Cells In Endometriosismentioning

confidence: 99%

Immunopathogenesis of endometriosis: An overview of the role of innate and adaptive immune cells and their mediators

Moghaddam

Ansariniya

Seifati

et al. 2022

American J Rep Immunol

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Background Endometriosis is a chronic inflammatory disease associated with the growth and proliferation of endometrial‐like tissues outside the uterus. Although the exact etiology and mechanism of the pathogenesis of the disease have not been fully elucidated, the immune system cells and the mediators produced by them can be named as effective factors in the onset and progression of the disease. Aims We aim to attempt to review studies on the role of the immune system in endometriosis to better understand the pathogenesis of endometriosis. Content Abundant production of inflammatory mediators by neutrophils and macrophages and reduced cytotoxicity of defined cells promote endometriosis at the early stages of the disease. Following an increase in the inflammation of the environment, the body takes compensatory mechanisms to reduce inflammation and establish homeostasis. For this purpose, the body produces remodeling and anti‐inflammatory factors leading to slow conversion of the inflammatory environment into a non‐inflammatory environment with proliferative and immunosuppressive properties. Environmental conditions induce M2 macrophages, TH2 cells, and Tregs differentiation, promoting disease progression by producing angiogenic and immunosuppressive factors. However, the exact molecular mechanism involved in changing inflammatory to non‐inflammatory conditions is not yet fully understood. Implications Due to the common characteristics of endometriotic cells and cancer cells, most potential treatment options for endometriosis have been suggested due to the results of these methods in the treatment of cancer. In this pathway, immune system cells and soluble mediators can be used as targets.

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Pelvic endometriosis and natural killer cell immunity

Cited by 35 publications

References 67 publications

The Role of the Immune System in the Development of Endometriosis

The Role of the Immune System in the Development of Endometriosis

Endometriosis: A Disease with Few Direct Treatment Options

Immunopathogenesis of endometriosis: An overview of the role of innate and adaptive immune cells and their mediators

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