Pelvic Ewing's Sarcoma: A Review from Scottish Bone Tumour Registry

Bhagat, Shaishav; Sharma, Himanshu; Pillai, D Aishwarya Raj; Jane, MJ

doi:10.1177/230949900801600313

Cited by 14 publications

(10 citation statements)

References 22 publications

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“…A total of 288 (22.1%) patients with Ewing sarcoma were included in the current analysis, with a 5‐year survival rate of 46%. The earlier reports on pelvic Ewing sarcoma reported survival rates only as high as 20% to 30% 32, 34. We believe that improvement in survival among patients over the past 2 decades can be attributed to improvements in multimodal therapy for Ewing sarcoma and radiological imaging.…”

Section: Discussionmentioning

confidence: 72%

“…The clinician is thus left wondering whether a uniform treatment strategy should be applied to all the patients regardless of the histopathology, as previously suggested, or each disease should be treated as a separate entity 1. An example of such a controversy is illustrated in the treatment recommendations for pelvic Ewing sarcoma, in which some authors have suggested considering radiotherapy as an alternative to surgery in pelvic Ewing sarcoma,30‐34 whereas others have stressed the importance of wide excision of the primary disease for this and other sarcomas 25, 35‐43…”

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confidence: 99%

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Malignant sarcoma of the pelvic bones

Jawad

Haleem

Scully

2010

Cancer

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Incidence of pelvic sarcoma in 2006 was 89 per 100,000 persons; it has significantly increased since 1973 (P < .05). The overall 5-year survival for all the patients with pelvic sarcoma was 47%, with osteosarcoma having the worst 5-year survival at 19% and patients with chordoma having the best 5-year survival at 60%. Independent prognostic factors included age, stage, grade, size of primary lesion, histopathology, and treatment-related factors. Comparing the patients only with high-grade lesions, patients with Ewing sarcoma have the best prognosis. CONCLUSIONS: This is an analysis of patients with pelvic sarcomas derived from a population-based registry. Survival and prognostics vary with histopathological diagnoses. Although surgical resection was associated with superior outcomes for osteosarcoma and chondrosarcoma, there was no significant difference in outcomes of patients with Ewing sarcoma treated with surgery and/or radiotherapy. Cancer 2011;117:1529-41.

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Section: Discussionmentioning

confidence: 72%

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confidence: 99%

Malignant sarcoma of the pelvic bones

Jawad

Haleem

Scully

2010

Cancer

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“…It occurs most commonly during the second decade of life. 5 Treatment includes neoadjuvant chemotherapy in association with surgery and/or radiation therapy. It is located most frequently at the pelvis or the femur.…”

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confidence: 99%

Ewing Sarcoma of the Acetabulum in Children

Gauzy

Lafontan

Ursei

et al. 2014

Journal of Pediatric Orthopaedics

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“…Pelvis is the most common sites for Ewing's sarcoma, but the prognosis is much poorer than those at other sites, because of lack of main anatomical barrier against dissemination of the tumor, difficult for local treatment due to many surrounding organs and neurovascular bundles, and more common recurrence than other sites [11]. However, Puri et al recommended aggressive surgical treatment for nonmetastatic Ewing's sarcoma at pelvic bone, because surgical resection as much as possible can lower local recurrence rates and provides excellent functional results, only if tumor resection margin is thought to be able to get obtained through preoperative imaging studies [12].…”

Section: Discussionmentioning

confidence: 99%

Long-Term Results of Ewing’s Sarcoma—In a Single Institution

Kim¹,

Kim²,

Chung³

2013

JCT

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Purpose: This study analyzed oncological and functional outcomes of treatment for Ewing's sarcoma, as well as its significant risk factors through long-term follow up. Objective and Method: Between September 1990 and April 2009, 20 cases that were diagnosed and treated as Ewing's sarcoma in Kosin University Gospel Hospital were entered onto the study. Mean follow-up period was 45.4 (12 -108) months. There were 7 cases of male and 13 cases of female, and mean age was 19.9 (5 -48) years old. Retrospective review was done about treatment outcomes, complications, and significant risk factors. Results: In terms of oncologic results, there were 9 cases of CDF (continuous disease free), 1 case of NED (no evidence of disease), 4 cases of AWD (alive with disease), 5 cases of DOD (dead of disease), and 1 case of DWOD (dead with other disease). Five-year overall survival rate of all the patients was 70.0% and event-free survival rate was 50.0%. The mean MSTS (Musculoskeletal Tumor Society) score was 15.9 (53%) points at last follow-up. Among prognostic factors of age at diagnosis, Enneking stage, size of tumor, site of primary lesion, and distant metastasis, 5-year survival rate of groups without metastasis were 90.9%, nevertheless 44.4% in other group with the metastasis showing statistical significance (p = 0.020). Postoperative complications were 3 cases of infection, each 2 cases of ankylosis and metal failure, and each 1 case of leg length discrepancy, periprosthetic fracture, and local recurrence. Conclusion: Five-year survival rate of this study was similar to that of multicenter studies in America and Europe. Among the prognostic factors, distant metastasis was proven to be most significant. Enneking stage, size of tumor and site of primary lesion are also important and could be statistically significant if with more cases.

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Pelvic Ewing's Sarcoma: A Review from Scottish Bone Tumour Registry

Abstract: Intense multi-agent neo-adjuvant chemotherapy including ifosfamide followed by wide excision and postoperative radiation are recommended. Local therapy should not take precedence over or interfere with systemic chemotherapy.

Cited by 14 publications

References 22 publications

Malignant sarcoma of the pelvic bones

Malignant sarcoma of the pelvic bones

Ewing Sarcoma of the Acetabulum in Children

Long-Term Results of Ewing’s Sarcoma—In a Single Institution

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