Pelvic floor disorders in gynecological malignancies. An overlooked problem?

Bodean, Oana; Marcu, Radu Dragos; Spinu, Dan Arsenie; Socea, Bogdan; Diaconu, Camelia Cristina; Munteanu, Octavian; Taus, Nicoleta; Cîrstoiu, Monica Mihaela

doi:10.22543/7674.51.p4652

Cited by 6 publications

(8 citation statements)

References 27 publications

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“…In our case, the hypothesis of chemotherapy induced non-melanoma skin cancer rose. However, in a case-control clinical trial by Rubino et al, no association was found between chemotherapy and non-melanoma skin cancer (14). The possibility that adjuvant chemotherapy influenced the aetiology of the skin cancer, in this case, is therefore low.…”

Section: Discussionmentioning

confidence: 67%

Vulvar basal cell carcinoma, a rare location

Nițipir¹,

Slavu²,

Orlov³

et al. 2018

J Clin Invest Surg.

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Basal Cell Carcinoma is the most common human malignant neoplasm. Vulvar basal cell carcinoma is rare, accounting for less than 5% of all vulvar neoplasms. Vulvar basal cell carcinomas are usually diagnosed late because they are often asymptomatic and tend to grow at slow rates. They are usually diagnosed late because they are often asymptomatic. However, these tumours may appear in areas which are normally covered with ultraviolet light. We present the case of a 60 years old woman diagnosed with invasive breast cancer for which she underwent surgery followed by chemotherapy and radiotherapy. The patient presented to our department with an ulcerated vulvar lesion. On inspection, the tumour measured 3/2 cm and was located on the left labium majus. The biopsy confirmed the diagnosis of vulvar basal cell carcinoma and a wide local excision was performed with no relapse at one year. In conclusion, early detection of BCC's is critical to allow complete surgical cure so any abnormality on the vulva should be biopsied. A wide safety margin of 1cm should be achieved when resecting the tumour and the physician should keep in mind that the BCC's of the vulva has a high recurrence rate. Previous chemotherapy is not associated with this type of non-melanoma skin cancer.

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Section: Discussionmentioning

confidence: 67%

Vulvar basal cell carcinoma, a rare location

Nițipir¹,

Slavu²,

Orlov³

et al. 2018

J Clin Invest Surg.

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“…The case that we reported presented a tumour size of more than 2 cm and it had grown more than 1 mm (0.04 inches) into underlying tissue (stroma) (T1b), no spread to the regional lymph nodes (N0) with no distant metastasis (M0) that was classified as stage IB according to AJCC and FIGO classifications. 6,32 In our case radical vulvectomy was necessary considering the tumour size. Separate incisions were given for inguinal lymphadenectomy, hence the triple butterfly incision.…”

Section: Discussionmentioning

confidence: 76%

Radical vulvectomy for a rare case of squamous cell carcinoma vulva: a case report

Nahar

2021

Int J Reprod Contracept Obstet Gynecol

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Cancer of the vulva is the fourth most common malignancy of the female genital tract. Vulvar carcinoma is a rare and aggressive gynecological malignancy. It affects elderly females, with the mean age at diagnosis being 55-60 years. Regional metastasis to inguinal lymph nodes is common. There is a high incidence of pelvic node involvement, especially in those with pathologically positive inguinal nodes. Surgery appears to be the only curative treatment option in the early stages of the disease. But in most patients, surgery is associated with considerable morbidities and psychosexual issues. Hence, in the quest for a less morbid form of treatment, multimodality approaches with various combinations of surgery, chemotherapy, and radiation therapy have been suggested for advanced vulvar cancers. Due to the low incidence of the disease, the level of evidence for the success of these treatment modalities is poor. Mrs. X, a 54-year-old female, P2L2 A0 presented at Apollo hospitals, Ahmedabad with a giant vulvar tumor of about 8x7 cm in size arising from anterior half of vulva involving clitoris and both labia minora. The vulval growth was initially small and had attained present size in last 15 days. She had complaints of postmenopausal bleeding per vaginum for 8 days, foul smelling discharge and itching vulva on and off for 1 month. Biopsy revealed moderate to well differentiated squamous cell carcinoma (SCC). MRI pelvis with contrast found suspicious lymph node in bilateral iliac vessel region and bilateral inguinal region. She underwent radical vulvectomy with bilateral inguinal lymph node dissection, and bilateral pelvic lymph node dissection. Early diagnosis, timely intervention and prompt surgical management could save the patient’s life. Histopathological report showed well differentiated SCC of vulva with no lymphnodes involvement. Depth of tumor was 12 mm and there was no lymphovascular and perineural invasion. All surgical margins and base of growth were free of tumor. According to TNM stabilization patient had SCC vulva stage IB (T1bN0M0). This patient was disease free after 18 months of follow-up. Vulvar cancer incidence is significantly high in post-menopausal and multiparous women. The most important prognostic factors are tumor stage and lymph node status. Oncological resection should be equated with functional outcome. The multidisciplinary team approach should be sought for this rare gynecological malignancy.

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“…The information required are the dimension and extent of the tumour, node status and presence of distant metastasis. The case that we reported presented a tumour less of 5 cm with invasion in the vulva and lower urethra (T2), spread in 4 regional lymph nodes (N2b) with no distant metastasis that was classified as stage IIIb according to AJCC and FIGO classifications (1,10).…”

Section: Discussionmentioning

confidence: 95%

A rare case of vulvar squamous cell carcinoma; case presentation

Cozma¹,

Răducu²,

Avino³

et al. 2018

J Clin Invest Surg.

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Objectives. Vulvar cancer is a rare gynecological malignancy, with an incidence of 1.5 per 100 000 women/year. The most common vulvar cancer is developed in squamous cells, the most encountered type of skin cells. Case report. We report a case of a 72-year-old female admitted in the Department of Plastic Surgery of Emergency Clinical Hospital "Prof. Dr. Agrippa Ionescu" with a 5/4.2 cm painful ulcerated tumoral mass located in the vulvar area. The lesion slowly increased in size over the past 12 months. The tumour was surgically removed with oncological safety margins and sent for histopathological evaluation. The histopathological examination revealed an ulcerated squamous carcinoma with lymphovascular and perineural invasion, but with negative margins. Postoperative results were favorable, and no local or general complications were observed. Conclusion. We highlight this case due to its unusual presentation in the clitoral area. Moreover, considering the potential for recurrence we point out the importance of the radical vulvectomy with regional lymphadenectomy and histopathological examination, in order to put a precise diagnosis and ensure the best possible treatment for the patient.

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Pelvic floor disorders in gynecological malignancies. An overlooked problem?

Cited by 6 publications

References 27 publications

Vulvar basal cell carcinoma, a rare location

Vulvar basal cell carcinoma, a rare location

Radical vulvectomy for a rare case of squamous cell carcinoma vulva: a case report

A rare case of vulvar squamous cell carcinoma; case presentation

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