Pelvic Lymph Node Dissection for Penile Carcinoma: Extent of Inguinal Lymph Node Involvement as an Indicator for Pelvic Lymph Node Involvement and Survival

Lont, A.P.; Kroon, Bin B. R.; Gallee, M.P.W.; Tinteren, Harm van; Moonen, L.; Horenblas, Simon

doi:10.1016/j.juro.2006.10.060

Cited by 163 publications

(102 citation statements)

References 14 publications

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“…And so further analysis with large study groups on perineural invasion and nodal disease will be needed in future. 14,15 …”

Section: Discussionmentioning

confidence: 99%

Clinical study of nodal involvement in carcinoma penis: role of perineural and perivascular invasion in lymph node metastasis

Kumar¹,

Venkateswaran²

2018

Int Surg J

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Background: Penile malignancies constitute a major health problem in the developing countries especially the Afro Asian countries. It constitutes about 10% of all malignancy. The incidence of the penile malignancy is in decreasing trend in many parts of the world due to improved awareness about the personal hygiene. In this study special effort was made to analyze the histopathological correlation in predicting the lymph node involvement particularly the perivascular and perineural invasion of a tumor on his to pathology and its influence on the lymph node metastasis.Methods: After getting prior ethical committee clearance 42 cases of histopathologically proven cases are included in the study. Those patients included are explained about the nature of the study, investigations that are done. They have also discussed the various treatment options available in Thanjavur medical college. Proper consent in patients own language is obtained before including in the study.Results: The most common histological type found in present study was squalors type. More than 90% (93%) shows squamous variety. Verrucous carcinoma was found in two patients. One patient present with the mixed presentation.Conclusions: Tumour with high grade, high stage, and perineural and per vascular invasion is associated with more nodal metastasis. It is highly recommended to carry out nodal dissection in such types of a tumor. Screening for the early stage of the disease and addressing for the inguinal nodes for the high-risk group will significantly reduce the morbidity and mortality of carcinoma penis.

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“…And so further analysis with large study groups on perineural invasion and nodal disease will be needed in future. 14,15 …”

Section: Discussionmentioning

confidence: 99%

Clinical study of nodal involvement in carcinoma penis: role of perineural and perivascular invasion in lymph node metastasis

Kumar¹,

Venkateswaran²

2018

Int Surg J

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“…This follows work that has demonstrated that the extent of metastatic disease in the nodes has great prognostic implications. 3,5 Series have shown 5-year mortality rates of roughly 25% for low-volume inguinal metastases and 75% for patients with greater than 2 positive nodes. 3,6 A recent large retrospective review of more than 100 patients undergoing lymphadenectomy for penile cancer demonstrated that disease in more than 2 lymph nodes, extracapsular nodal disease, bilateral node-positive disease and pelvic lymph node metastasis are independent prognostic factors for disease-specific survival.…”

Section: Burden Of Inguinal Diseasementioning

confidence: 99%

“…2,6 In a series by Lont and colleagues, 5 25 of 102 patients (25%) with pathologically proven inguinal metastases were later proven to have pelvic node disease, and 4 of these patients (16%) achieved long-term disease-free survival. Risk factors for the presence of pelvic nodal disease in patients with inguinal node disease included more than 2 positive nodes, extracapsular extension of disease and presence of high-grade cancer in inguinal nodes.…”

Section: Pelvic Lymph Nodesmentioning

confidence: 99%

“…[4][5][6] Presentation with visceral metastatic disease is rare. 6 Drainage to one or both sides is possible and has been shown to be reproducibly demonstrable with lymphoscintigraphy in the same patient at different times.…”

mentioning

confidence: 99%

“…4,7,8 Recent series have demonstrated rates of clinical node positivity at presentation between 22% and 61%. 5,9,10 Lymphadenopathy in patients with clinically palpable nodal disease should be reconciled between reactive adenopathy and true metastatic disease, as infection of this cutaneous neoplasm can also enlarge nodes in the groin. False-positive rates for palpable adenopathy can exceed 50%.…”

mentioning

confidence: 99%

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What next? Managing lymph nodes in men with penile cancer

Leveridge

Morash

2013

CUAJ

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The management of patients with squamous cell carcinoma of the penis is often daunting given its rarity and subsequent lack of high-level evidence to support our decision-making. This culminates in the complex surgical issues involving the management of the regional lymph nodes, which is of critical importance to both quantity and quality of life for these patients. This review aims to highlight the decisive issues surrounding the management of the pelvic and inguinal lymph nodes in the setting of squamous cell carcinoma of the penis, and to spotlight recently published information that adds credence to accepted management strategies of both the clinically positive and negative groin after successful management of the primary lesion.

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