PEM Anchorage on Titanium Using Catechol Grafting

Abstract

BackgroundThis study deals with the anchorage of polyelectrolyte films onto titanium surfaces via a cathecol-based linker for biomedical applications.MethodologyThe following study uses a molecule functionalized with a catechol and a carboxylic acid: 3-(3,4-dihydroxyphenyl)propanoic acid. This molecule is anchored to the TiO2 substrate via the catechol while the carboxylic acid reacts with polymers bearing amine groups. By providing a film anchorage of chemisorption type, it makes possible to deposit polyelectrolytes on the surface of titanium.Principal FindingsInfrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), contact angle and atomic force microscopy (AFM) measurements show that the different steps of grafting have been successfully performed.ConclusionsThis method based on catechol anchorage of polyelectrolytes open a window towards large possibilities of clinical applications.

Chitosan coating as an antibacterial surface for biomedical applications

“…In order to bond chitosan to a titanium support, several methods are considered in the literature; such as the dopamine glutaraldehyde method [ 21 ], the electrodeposition of chitosan on substrates [ 22 ], or the use of catechol functional groups [ 23 ]. Another strategy consists of using an organosilane as a coupling agent; such as 3-AminoPropylTriEthoxySilane (APTES) associated with glutaraldehyde or succinic anhydride [ 24 – 27 ] or TriEthoxySilylPropylSuccinic Anhydride (TESPSA) [ 28 ].…”

A Facile Surface Modification Scheme for Medical-Grade Titanium and Polypropylene Using a Novel Mussel-Inspired Biomimetic Polymer with Cationic Quaternary Ammonium Functionalities for Antibacterial Application

“…In contrast, the contact angle of the PQA-C8-modified titanium, prepared with the oxidants while without the dopamine addition (10:0-Ti CuSO 4 /H 2 O 2 ), remained similar to the untreated bare titanium control ( p > 0.05). This may be attributed to the added oxidants hindering the transformation of surface Ti-OH formed after piranha solution cleaning to the Ti-O-Ti that can facilitate the surface bonding of PQA-C8 through the quinone end, the terminal end formed after oxidation of catechol [ 60 ]. Reduced transformation of the catechol end to the quinone structure due to the bulky cationic polymer end, as compared to the dopamine, could likely contribute to this finding.…”

“…The two-step modification scheme utilized here was immersing the substrate into the dopamine solution first and then immersing in the PQA-C8 solution. This two-step modification scheme was not attempted on the titanium substrate since the surface titanium oxide layer on the Ti substrate (see Section 3.2.3 XPS analysis) can be bound with the catechol functionalized polymers by chemisorption [ 60 ]. In contrast, the PP surface presented only a small number of oxygen-containing functionalities, likely the hydroxyl groups (see Section 3.2.3 XPS analysis, Table 4).…”