North Aceh Regency and Lhokseumawe City’s waters are mangrove ecosystems, estuaries, fisheries management activities, and industrialization activities. Activities in the industrial areas of North Aceh Regency and Lhokseumawe City have the ability to contaminate waters and affect the chemical and physical composition of the water, which has a direct impact on the abundance of harmful bacteria (Vibrio sp). The study looked at the distribution of harmful bacteria (Vibrio sp) in water near industrial areas in North Aceh Regency and Lhokseumawe City. The purpose of this study is to investigate the abundance of pathogenic bacteria (Vibrio sp.) in the waterways of North Aceh Regency and Lhokseumawe City's industrial areas. This study will also look into the relationship between water quality factors and the abundance of harmful bacteria. The study was carried out in July and August 2023 at four stations placed in marine waters near the industrial area. The research methods used in this research are survey methods and laboratory analysis. Purposive sampling and the ANOVA test were the analysis and sampling techniques employed in this study. The findings demonstrated that there was no discernible variation in Vibrio parahaemolyticus between stations 1, 2, 3, and 4. Station 2 saw a strong Vibrio cholerae effect (p > 0.05), resulting in 87.20 74.36b CFU/ml. Vibrio total from the four research stations that significantly affected station 2 (p > 0.05) were 280.00 167.26b CFU/ml.