Pemphigoid der Neugeborenen und Kinder

Tachau, Paul

doi:10.1007/978-3-7091-5415-1_4

Pyodermien Morbus Bang 1934

DOI: 10.1007/978-3-7091-5415-1_4

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Pemphigoid der Neugeborenen und Kinder

Paul Tachau¹

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1940

1977

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Cited by 5 publications

(1 citation statement)

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“…Generalized staphylococcal scalded skin syndrome (SSSS) is most frequently encountered in neonates and infants. This age predilection is so characteristic that, previously, neonatal age was considered a prerequisite for the diagnosis (Ritter von Rittershain, 1975;Tachau, 1934). Today, cases are recognized in childhood and, rarely, even in adults (Epstein, Flynn & Davis, 1974;Hawley & Aronson, 1973;Levine & Norden, 1972;Reid, Weston & Humbert, 1974;Rothenberg et al:, 1973).…”

mentioning

confidence: 99%

The fate of Staphylococcal exfoliatin in newborn and adult mice*

1976

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The distribution and excretion of the staphylococcal exfoliatin was investigated following in vivo administration of highly purified 125I-labelled exfoliatin fractions to adult and newborn mice. Adult mice excrete approximately one-third of a test dose by 3 hours as compared to a fifteenth of a test dose excreted by newborn mice. Accordingly, blood tracer radioactivity reaches a relatively higher peak and shows a slower decline in newborns than in adults. The urine of adult mice contains considerable biologically active exfoliating material. Both nephrectomized and carbon tetrachloride-poisoned adult mice injected with exfoliatin develop generalized exfoliation whereas comparable doses in untreated controls have no effect. On the other hand, subtotal hepatectomy, followed by injection of exfoliatin, does not lead to exfoliation. We conclude that renal immaturity is a critical factor responsible for the susceptibility of neonates to generalized staphylococcal scalded skin syndrome.

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The fate of Staphylococcal exfoliatin in newborn and adult mice*

1976

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Staphylococcal scalded skin syndrome. Clinical features, pathogenesis, and recent microbiological and biochemical developments

Elias¹

1977

Archives of Dermatology

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The essential clinical features of staphylococcal scalded skin syndrome (SSSS) and otherforms of toxic epidermal necrolysis (TEN) are contrasted. Whereas TEN is a devastating disease of multiple causes and of high fatality affecting all age groups, SSSS comprises many clinical entitles that occur primarily in early childhood and is caused by certain phage group 2 staphylococci. Because of the high cleavage plane, the barrier is only translently perturbed, and rapid recovery is the rule. Although the early stages of SSSS may resemble other widespread dermatoses clinically, the correct diagnosis is suggested, even prior to frank exfoliation, by the presence of cutaneous tenderness and a positive Nikolski sign. However, rapid bedside confirmation is now possible with exfoliative cytology and frozen sections. Recent availability of in vivo and in vitro animal models of SSSS have advanced the knowledge of the disease: the responsible epidermolytic toxin has been characterized, and the purely extracellular pathogenesis of SSSS has been established. The epidermolytic toxin is strikingly species and tissue specific, attacking only certain keratinizing epithelia of mice, hamsters, monkeys, and man. The lower incidence of SSSS in adults is primarily due to a supreior capacity to metabolize and excrete the toxin, as well as more efficient immune capabilities. The mechanisms of epidermolytic toxin action and the molecular site of action are still the focus of active investigation.

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Staphylococcic Impetigo Contagiosa

Epstein¹

1940

Arch Dermatol

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Pemphigoid der Neugeborenen und Kinder

Cited by 5 publications

References 56 publications

The fate of Staphylococcal exfoliatin in newborn and adult mice*

The fate of Staphylococcal exfoliatin in newborn and adult mice*

Staphylococcal scalded skin syndrome. Clinical features, pathogenesis, and recent microbiological and biochemical developments

Staphylococcic Impetigo Contagiosa

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