Pemphigoid gestationis autoantigen, transmembrane collagen XVII, promotes the migration of cytotrophoblastic cells of placenta and is a structural component of fetal membranes

Pemphigoid gestationis: A Moroccan study

“…The pregnancy risks of PG are thought to be associated with mild placental failure caused by BP180 antibodies [25,26]. In addition to accumulation of C3 complement and IgG, mild villitis and collections of immature fibrotic villi have been observed in histologic examinations of PG placentas [27]. Antibody concentrations do not as such correlate with the occurrence of pregnancy complications, and no association has been demonstrated between cortisone treatment and PG pregnancy complications [25].…”

Bullous Dermatoses in Pregnancy

“…Interestingly healthy pregnant women can develop antibodies specific for BP180, and these autoantibodies are capable of binding both cyntitiotrophoblasts and placental amnion. In a large serological study on gravid and nongravid women, IgE but not IgG antibodies reactive against the NC16A domain of BP180 were found in 7.7 % pregnant women (n0299) and in 2.2 % nonpregnant healthy controls (n0134), all with normal serum IgE and IgG level [7].…”

“…Furthermore, confirmed by immunoblotting, the amnion tissue contained desmogleins 1 and 3, desmocollins 1 and 2, desmoplakins 1 and 2, three subunits (alpha3, beta3, and gamma2) of laminin 332, bullosus pemphigoid antigen 1 (BPAg 1 0 BP180) and BPAg2 (BP230), the 97-kDa linearis IgA dermatosis (LAD) antigen and type VII collagen [5,6]. Full-length BP180 was detected by Western immunoblot or by flow cytometry and indirect immunofluorescence (IF) in placental and cytotrophoblast cell lysates and cell cultures [7].…”

“…The histopathology of PG placentas shows mild villitis with normal collagen XVII expression levels or immunostaining pattern [7]. The BPAg 2 shed domain could contribute to the invasion of extravillous cytotrophoblasts during placental development and to the stabilization of epithelial amnion membrane [7].…”

Pemphigoide Gestationis a Propos Dun Cas Et Revue De La Litterature.

“…Discussion:-La pemphigoïde de la grossesse survient préférentiellement chez des femmes porteuses des HLA-DR3et DR4 [2] et est due à des auto-anticorps, de type IgG4 surtout [3], dirigés contre la protéine transmembranaire hémi-desmosomale BP180. La synthèse des auto-anticorps est consécutive à une rupture de la tolérance immunologique mère-foetus [4]. La PG se manifeste cliniquement par une éruption prurigineuse, érythémato-papuleuse, urticarienne, parfois en cocarde, plus ou moins étendue, débutant classiquement sur le ventre mais pas toujours, évoluant vers l'apparition inconstante (60 à 80 % des cas) mais évocatrice de vésicules et bulles.…”