Pemphigoid gestationis: Clinical and histologic features of twenty-three patients

Hallaji, Zahra; Mortazavi, Hossein; Ashtari, Sara; Nikoo, Azita; Abdollahi, Mohammad; Nasimi, Maryam

doi:10.1016/j.ijwd.2016.11.004

Cited by 33 publications

(46 citation statements)

References 23 publications

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“…Both primiparous and multiparous women are affected, but most cases are reported to occur in multiparous women, 11 , 14 , 19 although this is not congruent with a study of 23 cases where 56.5% of the women with PG were primiparous. 15 There is no association between change in partner and development of PG, 14 which was previously suggested. 22 …”

Section: Epidemiology and Risk Factorsmentioning

confidence: 78%

“…Recurrences in subsequent pregnancies are common and are usually more severe and with an earlier onset. 1 , 15 , 17 , 20 Studies show recurrences in 33%–50% of patients, 11 , 21 but cases of uninvolved or skipped pregnancies following a previously affected pregnancy are also reported. In a case study including 25 patients with PG, 2 patients (8%) presented with an uninvolved pregnancy following a previously affected pregnancy.…”

Section: Epidemiology and Risk Factorsmentioning

confidence: 99%

“…Pruritus can remain the only symptom, but mostly it develops into eruptive polymorphic skin lesions. 2 , 15 , 16 Eruptive skin lesions initially present as urticarial papules and annular plaques, followed by vesicles and finally large tense bullae on an erythematous background ( Figure 1 ). Skin lesions typically develop on the abdomen, characteristically involving the umbilical region ( Figures 2 and 3 ).…”

Section: Clinical Featuresmentioning

confidence: 99%

“… 29 In a study of 23 patients, extremities were the most common site of involvement (100%). 15 The mucous membranes and face are usually spared. 18 , 31 …”

Section: Clinical Featuresmentioning

confidence: 99%

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Pemphigoid gestationis: current perspectives

Sävervall

Sand

Thomsen

2017

CCID

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Many skin diseases can occur in pregnant women. However, a few pruritic dermatological conditions are unique to pregnancy, including pemphigoid gestationis (PG). As PG is associated with severe morbidity for pregnant women and carries fetal risks, it is important for the clinician to quickly recognize this disease and refer it for dermatological evaluation and treatment. Herein, we review the pathogenesis, clinical characteristics, and management of PG.

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Section: Epidemiology and Risk Factorsmentioning

confidence: 78%

Section: Epidemiology and Risk Factorsmentioning

confidence: 99%

Section: Clinical Featuresmentioning

confidence: 99%

“… 29 In a study of 23 patients, extremities were the most common site of involvement (100%). 15 The mucous membranes and face are usually spared. 18 , 31 …”

Section: Clinical Featuresmentioning

confidence: 99%

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Pemphigoid gestationis: current perspectives

Sävervall

Sand

Thomsen

2017

CCID

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“…Такі пацієнтки мають бути поінфор мовані про можливий перебіг захворювання, методи лікування та ефективність, а також про прогноз для плода і можливе виникнення цього стану, особливо під час наступних вагітностей. Також слід зазначити, що при повторному вини кненні пемфігусу в пацієнток можливий ранній початок і тяжчий перебіг захворювання [8].…”

Section: клінічний випадок успішного лікування внутрішньовенними імунunclassified

Clinical case of effective treatment of gestational pemphigoid with intravenous immunoglobulins

Yavir¹,

Spichak²,

Berestovoy³

et al. 2020

UJPP

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Gestational pemphigus — is a rare autoimmune condition that manifest during pregnancy. This pathology was described for the first time in 1827 by the Karl Martius, but until now remains insufficiently studied and as a result, difficulties arise in the differential diagnosis and treatment. Clinical manifestations of the disease characterized by the appearance of a polymorphic rash on the skin and mucous membranes. In patients with impaired immune tolerance pemphigus can be complicated by hyperactivation of the immune system. To date, pregnancy is not considered as a factor that can aggravate the course of pemphigus, since during pregnancy the disease can worsen, enter into complete remission, or remain unchanged. In the literature, there is information about the manifestation of pemphigus in puerperium after rapid decrease of corticosteroid hormones in serum. The clinical course of gestational pemphigus is variable and can lead to diagnostic failures. The diagnosis usually made according to the clinic, histopathology and laboratory findings. In this case report we describe a case of diagnosis and treatment of gestational pemphigoid, refractory to corticosteroid therapy. Clinical improvement and recovery achieved after a course of high doses of intravenous immunoglobulins. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of these Institutes. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: pemphigoid, pregnancy, autoimmune disease, intravenous immunoglobulin.

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Dermatoses of Pregnancy

Stanway

2024

Rook's Textbook of Dermatology

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This chapter provides a comprehensive overview of dermatological conditions affecting women during pregnancy. It includes specific dermatoses of pregnancy, itch during pregnancy, systemic and cutaneous infections with specific relevance to dermatology, autoimmune and inflammatory skin conditions affecting pregnant woman and the management of skin tumours during pregnancy. Physiological skin changes during pregnancy and an overview on safe treatments for use in dermatological conditions during pregnancy are reviewed.

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Pemphigoid gestationis: Clinical and histologic features of twenty-three patients

Cited by 33 publications

References 23 publications

Pemphigoid gestationis: current perspectives

Pemphigoid gestationis: current perspectives

Clinical case of effective treatment of gestational pemphigoid with intravenous immunoglobulins

Dermatoses of Pregnancy

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