Pemphigus: analysis of 262 cases

Benchikhi, H.; Ghafour, S.; Disky, A.; Bichra, Leila; Nejjam, F.; Lakhdar, H.

doi:10.1111/j.1365-4632.2008.03616.x

Cited by 9 publications

(20 citation statements)

References 12 publications

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“…Indeed, their variation index at diagnosis and 6-month of follow-up was similar. This data suggests that both deep and superficial pemphigus are severe condition in Moroccan patients and this was previously shown [10]. In contrast, in the Japenese studies, many severe cases were pemphigus vulgaris, while the majority of moderate cases are shown to be pemphigus foliaceus [2, 3].…”

Section: Discussionsupporting

confidence: 53%

Pemphigus: use of the Japanese severity index in 56 Moroccan patients

Benchikhi¹,

Nani²,

Baybay³

et al. 2013

Pan Afr Med J

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IntroductionIn pemphigus, there still is no consensus on parameters mesuring clinically the disease severity. The aim of this study is to use the Japanese severity index in Moroccan patients with pemphigus.MethodsMulticenter prospective study from September 2007 to September 2009 including consecutive patients with confirmed pemphigus. We used the Japenese severity index for pemphigus. For each patient, the score was calculated at diagnosis and at 6 months of follow-up and correlated to type of pemphigus; mean dosage of corticosteroids and clinical statuts at 6 months: dead or not.ResultsFifty six patients were included, 20 men and 36 women, mean age 46.62 ± 15.9 years. At diagnosis, the mean initial score was 7.7 + 2.36; at six months, it was 1.61 + 1.83. The score variation at 6 months and inclusion was 6.19 ± 2.18 for deep pemphigus and 5.43 ± 2.85 for superficial pemphigus (p = 0,3 non significant). At six months, 4 patients were dead: their initial score was 11 + 1.41 while the initial score in the 52 patients was 7.4±2.03 (p = 0,001, significant). Data showed no correlation between initial severity scores and cumulative dosage of corticosteroids at 6 months (Pearson coefficient of correlation 0.144; p = 0.580).ConclusionIn this study, initial severity scores for pemphigus were high and decreased at 6 months of treatment. Both deep pemphigus and superficial pemphigus were severe as their score variation was similar. Japenese severity score is useful for Moroccan patients with pemphigus.

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Section: Discussionsupporting

confidence: 53%

Pemphigus: use of the Japanese severity index in 56 Moroccan patients

Benchikhi¹,

Nani²,

Baybay³

et al. 2013

Pan Afr Med J

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“…Both pemphigus subtypes are present in many Arab countries . However, there is variation in the dominant clinical phenotype among countries.…”

Section: Types Of Pemphigus In the Arab Worldmentioning

confidence: 99%

“…Moreover, personal communication with dermatologists from some Arab countries revealed that PV is the commonest subtype in Jordan, Iraq and Algeria while PF is more common in Mauritania. On the other hand, pemphigus is rare (0–1 cases/year) in Qatar, Lebanon and Bahrain.…”

Section: Types Of Pemphigus In the Arab Worldmentioning

confidence: 99%

“…For example, in Morocco, although PV is the predominant clinical phenotype in the country, PF is more common in Marrakech which is the second largest city. Moreover, in Casablanca, which is the largest city, the distribution of PF and PV is nearly the same . Moreover, although PF is endemic in Tunisia, a study from North Tunisia revealed that PV represented 61% of total pemphigus patients in an 11‐year period …”

Section: Types Of Pemphigus In the Arab Worldmentioning

confidence: 99%

“…Epidemiological studies were not done in Morocco, Egypt, Jordan, Algeria and Mauritania, despite the disease being relatively frequent . Thirteen new cases are diagnosed per year in Morocco, approximately 20 new cases in Egypt per year (Cairo University hospital records), approximately 15 new cases in Jordan per year and approximately 10 new cases in Mauritania (Dr Salma Bint Yahya and Dr. Mariem Kébé, pers. comm., 2014).…”

Section: Epidemiology Of Pemphigus In the Arab Worldmentioning

confidence: 99%

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Pemphigus in the Arab world

Saleh

2015

The Journal of Dermatology

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The Arab world lies geographically between the Atlantic coasts of northern Africa and the Arabian Gulf. This area has wide latitudinal differences as well as variable environmental conditions ranging from deserts to forests. Approximately 370 million individuals who share the Arabic language live in this area. Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are the main subtypes of the pemphigus disease. Both pemphigus subtypes are present in many Arab countries; however, there is variation in the predominant subtype among countries. PV is the most common subtype in Egypt, Sudan, Morocco, Syria, Kuwait, Saudi Arabia and Yemen. On the other hand, PF is more prevalent in Libya and is endemic in Tunisia. Interestingly, there is variation in the dominant subtype in some cities within Morocco. For example, PF is more common in Marrakech which is the second largest city. The presence of anti-desmoglein 1 antibodies in the sera of normal Tunisians and the presence of anti-desmoglein 3 in normal Egyptians' sera suggested that environmental factors played a role in the disease pathogenesis in those areas. Further researches detected that traditional cosmetics were among the risk factors in Tunisia. Moreover, farming was suggested as a risk factor in Egypt, Tunisia and Sudan. Because there is no consensus for pemphigus treatment among the Arab countries, there is diversity in their pemphigus treatment regimens. Studying the demographic characteristics and the environmental conditions which caused the variations in the prevailing clinical phenotype will help us fill the gaps to understand the pathogenesis of the pemphigus disease.

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Geographic variations in epidemiology of two autoimmune bullous diseases: pemphigus and bullous pemphigoid

2015

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Autoimmune bullous diseases are rare, organ-specific, a group of blistering disease of skin and mucous membranes. Recent studies suggest that the frequency of the autoimmune bullous diseases has been increasing. Pemphigus vulgaris and bullous pemphigoid are the most frequently reported autoimmune bullous diseases. High incidence of autoimmune bullous diseases in some ethnic groups such as pemphigus in Ashkenazi Jewish, or in some regions such as pemphigus foliaceus in Brazil has been shown to be related to genetic and environmental factors, respectively. Pemphigus has been reported more frequently in the female gender. Although it is most frequently diagnosed between the ages 50 and 60 in European countries, in the remaining countries in the world, it is seen between the ages of 30 and 50. Bullous pemphigoid is generally seen above 70 years of age. Although overall incidence is slightly higher in females, after the age of 80 years it is more frequent in males. Both pemphigus vulgaris and bullous pemphigoid has a chronic course with recurrences. Mortality risk of the patients with bullous pemphigoid was found at least 2 times higher and the mortality risk of the patients with pemphigus was found approximately 3 times higher than that of the general population. In this review, the results obtained from the epidemiological studies were analyzed according to geographic regions, and especially epidemiologic features of two prevalent autoimmune bullous diseases, pemphigus and bullous pemphigoid have been discussed.

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Pemphigus: analysis of 262 cases

Cited by 9 publications

References 12 publications

Pemphigus: use of the Japanese severity index in 56 Moroccan patients

Pemphigus: use of the Japanese severity index in 56 Moroccan patients

Pemphigus in the Arab world

Geographic variations in epidemiology of two autoimmune bullous diseases: pemphigus and bullous pemphigoid

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