Pemphigus foliaceus exacerbated by radiation, in association with myasthenia gravis

Liebman, Tracey N.; Lieberman, Miriam; Burris, Katy

doi:10.5070/d3223030361

Cited by 5 publications

(1 citation statement)

References 14 publications

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“…They are identical [ 43 ], except for higher anti-DSG1 IgM and IgE serum levels in endemic PF [ 44 , 45 , 46 ]. In contrast to PV, association with other autoimmune diseases and longitudinal mother-child transmission are very rare [ 30 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 ]. If affected, newborns soon recover [ 47 ].…”

Section: Introductionmentioning

confidence: 99%

Marked to Die-Cell Death Mechanisms for Keratinocyte Acantholysis in Pemphigus Diseases

Bumiller-Bini

Schneider

Pumpe

et al. 2022

Life

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Pemphigus is a group of blistering autoimmune diseases causing painful skin lesions, characterized by acantholysis and by the production of autoantibodies against, mainly, adhesion proteins. We reviewed the literature for molecules and/ or features involved in the 12 cell death pathways described by Nomenclature Committee on Cell Death, taking place in pemphigus patients, cell lines, or human skin organ cultures treated with sera or IgG from pemphigus patients or in pemphigus mouse models, and found 61 studies mentioning 97 molecules involved in cell death pathways. Among the molecules, most investigated were pleiotropic molecules such as TNF and CASP3, followed by FASL and CASP8, and then by FAS, BAX, BCL2, and TP53, all involved in more than one pathway but interpreted to function only within apoptosis. Most of these previous investigations focused only on apoptosis, but four recent studies, using TUNEL assays and/or electron microscopy, disqualified this pathway as a previous event of acantholysis. For PV, apoptolysis was suggested as a cell death mechanism based on pathogenic autoantibodies diversity, mitochondrial dysfunction, and p38 MAPK signaling. To answer those many questions that remain on cell death and pemphigus, we propose well-controlled, statistically relevant investigations on pemphigus and cell death pathways besides apoptosis, to overcome the challenges of understanding the etiopathology of pemphigus diseases.

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Section: Introductionmentioning

confidence: 99%

Marked to Die-Cell Death Mechanisms for Keratinocyte Acantholysis in Pemphigus Diseases

Bumiller-Bini

Schneider

Pumpe

et al. 2022

Life

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Pemphigus trigger factors: special focus on pemphigus vulgaris and pemphigus foliaceus

Tavakolpour

2017

Arch Dermatol Res

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Pemphigus is a general term for a rare group of autoimmune diseases which result in the formation of blisters on the skin and oral cavity. Although there is no way to prevent autoimmune diseases, some factors may trigger pemphigus initiation in susceptible individuals or be exacerbated in affected patients. Recognition of these triggers, based on the latest studies and experiences is essential and should be updated every few years. In this study, several triggers, including different drugs and treatments, diseases, vaccines, genetic factors, nutrients, micronutrients, pregnancy, stress, and various other triggers have been discussed. Some possible triggers, such as blood antigens and the effect of seasons have also been discussed briefly. Moreover, some protective factors against pemphigus have been reviewed. Considering the molecular mechanism of pemphigus and immune response alteration during this disease, some possible triggers have been suggested and discussed. Although those triggers may be a real threat, more studies are needed to support these hypotheses.

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Risk of radiotherapy-associated autoimmune bullous disease among Taiwanese patients with breast cancer: a case–control study

et al. 2019

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Pemphigus foliaceus exacerbated by radiation, in association with myasthenia gravis

Cited by 5 publications

References 14 publications

Marked to Die-Cell Death Mechanisms for Keratinocyte Acantholysis in Pemphigus Diseases

Marked to Die-Cell Death Mechanisms for Keratinocyte Acantholysis in Pemphigus Diseases

Pemphigus trigger factors: special focus on pemphigus vulgaris and pemphigus foliaceus

Risk of radiotherapy-associated autoimmune bullous disease among Taiwanese patients with breast cancer: a case–control study

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