Pemphigus foliaceus induced by topical imiquimod treatment

Shiraishi, Ken; Sayama, Koji

doi:10.1111/ijd.14204

Cited by 8 publications

(8 citation statements)

References 10 publications

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“…The rapid response to prednisone further supports an inflammatory etiology. Our patient's onset of blistering eruption two months after starting imiquimod is within the time range of 1 week to 2 months reported in previous studies . The prognosis of pemphigus related to medications is good, as cessation of the inciting drug generally prevents flares of the disease …”

Section: Discussionsupporting

confidence: 78%

“…Imiquimod has been reported to induce and exacerbate existing pemphigus in adults . In children, there has been a report of localized cytokine dermatitis .…”

Section: Discussionmentioning

confidence: 99%

“…Imiquimod has been reported to induce and exacerbate existing pemphigus in adults. 1,2 In children, there has been a report of localized cytokine dermatitis. 3 This is the first case of a imiquimod-induced pemphigus-like eruption in a child, distant to the site of imiquimod application.…”

Section: Discussionmentioning

confidence: 99%

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Pemphigus‐like eruption as a complication of molluscum contagiosum treatment with imiquimod in a 5‐year‐old girl

Zhong

Hasbun

Jones

et al. 2020

Pediatric Dermatology

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Pemphigus and pemphigus‐like reactions can be triggered by a variety of medications including topical therapies, such as imiquimod. While the association between imiquimod and pemphigus‐like reactions has been reported in adults, this is the first report of a generalized reaction beyond the site of imiquimod application in a child. The mechanism by which this occurs may be through a unique pathway, separate from the classic antibody‐mediated pathway. Our patient had a full recovery without recurrence after cessation of the inciting drug.

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Section: Discussionsupporting

confidence: 78%

“…Imiquimod has been reported to induce and exacerbate existing pemphigus in adults . In children, there has been a report of localized cytokine dermatitis .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pemphigus‐like eruption as a complication of molluscum contagiosum treatment with imiquimod in a 5‐year‐old girl

Zhong

Hasbun

Jones

et al. 2020

Pediatric Dermatology

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“…Table 1 summarizes the clinical and laboratorial data of the previous 7 cases (4 PF and 3 PV). [9][10][11][12][13][14][15] Although the histopathological examination was not the characteristic of PF, the typical clinical presentation, the DIF and IIF data, and the anti-Dsg-1 positivity results supported the PF diagnosis. Despite not being commonly described in pemphigus, the presence of eosinophils in the skin biopsies of the compiled cases (Table 1) deserves attention.…”

Section: Imiquimod-associated Pemphigus Foliaceusmentioning

confidence: 86%

Imiquimod-Associated Pemphigus Foliaceus

Farid

Lugão

Julio

et al. 2020

American Journal of Therapeutics

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“…This phenomenon indicates that inflammation in peripheral tissues can affect central immune tolerance and potentially contribute to the development of autoimmune diseases. In human clinical practice, the development of PF has been reported after topical application of imiquimod cream 90,91 . Its clinical relevance has also been discussed based on the fact that imiquimod is an agonist of TLR7.…”

Section: T Cell Tolerance In Pemphigusmentioning

confidence: 99%

T cell autoimmunity and immune regulation to desmoglein 3, a pemphigus autoantigen

Takahashi

Iriki

Asahina

2022

The Journal of Dermatology

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Pemphigus is a life‐threatening autoimmune bullous disease mediated by anti‐desmoglein IgG autoantibodies. Pemphigus is mainly classified into three subtypes: pemphigus vulgaris, pemphigus foliaceus, and paraneoplastic pemphigus. The pathogenicity of autoantibodies has been extensively studied. Anti‐human CD20 antibody therapy targeting B cells emerged as a more effective treatment option compared to conventional therapy for patients with an intractable disease. On the other hand, autoreactive T cells are considered to be involved in the pathogenesis based on the test results of human leukocyte antigen association, autoreactive T cell detection, and cytokine profile analysis. Research on the role of T cells in pemphigus has continued to progress, including that on T follicular helper cells, which initiate molecular mechanisms involved in antibody production in B cells. Autoreactive T cell research in mice has highlighted the crucial roles of cellular autoimmunity and improved the understanding of its pathogenesis, especially in paraneoplastic pemphigus. The mouse research has helped elucidate novel regulatory mechanisms of autoreactive T cells, such as thymic tolerance to desmoglein 3 and the essential roles of regulatory T cells, Langerhans cells, and other molecules in peripheral tissues. This review focuses on the immunological aspects of autoreactive T cells in pemphigus by providing detailed information on various related topics.

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Pemphigus foliaceus induced by topical imiquimod treatment

Cited by 8 publications

References 10 publications

Pemphigus‐like eruption as a complication of molluscum contagiosum treatment with imiquimod in a 5‐year‐old girl

Pemphigus‐like eruption as a complication of molluscum contagiosum treatment with imiquimod in a 5‐year‐old girl

Imiquimod-Associated Pemphigus Foliaceus

T cell autoimmunity and immune regulation to desmoglein 3, a pemphigus autoantigen

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