Pemphigus

Abstract

Pemphigus is a potential life- and sight-threatening disease. Understanding the disease facilitates the adequate assessment of the modifiable factors and the prompt initiation of immunotherapy. Ocular involvement can develop in patients with pemphigus. Adequate ophthalmological care is needed, in particular, prevention of infections, scarring, and corneal perforation.

Persistent Symmetrical Erythema and Scaling of the Face and Scalp: Pemphigus Foliaceus: Answer

“…6 Associated drugs include thiols (ie, penicillamine, captopril), phenols (ie, aspirin, cephalosporins), and nonthiol, nonphenol drugs including others NSAIDs, ACE-inhibitors, and nifedipine. 6…”

“…1,2 Because of this, ocular involvement is more common in PV than in PF. 6 Direct immunofluorescence may be necessary to distinguish IgA pemphigoid, which would show greater IgA than IgG positivity. 1,3 Bullous pemphigoid targets below the epidermis at the dermal-epidermal junction, and the blisters are more durable than in PF or PV.…”

“…6 Associated drugs include thiols (ie, penicillamine, captopril), phenols (ie, aspirin, cephalosporins), and nonthiol, nonphenol drugs including others NSAIDs, ACE-inhibitors, and nifedipine. 6 Treatment typically includes the use of systemic corticosteroids to achieve immediate control followed by immunomodulating systemic therapy. Our patient is being treated with oral corticosteroids, rituximab (2 doses, 1000 mg, 2 weeks apart), and mycophenolate mofetil (2-3 g/d) and is doing well.…”

“…7 Drug-induced pemphigus is often preceded by nonspecific cutaneous lesions resembling common rashes with a variable latency period before appearance of genuine pemphigoid lesions. 6 Associated drugs include thiols (ie, penicillamine, captopril), phenols (ie, aspirin, cephalosporins), and nonthiol, nonphenol drugs including others NSAIDs, ACE-inhibitors, and nifedipine. 6 Treatment typically includes the use of systemic corticosteroids to achieve immediate control followed by immunomodulating systemic therapy.…”

<b><i>Aeromonas hydrophila</i></b> Panophthalmitis in Pemphigus Vulgaris: A Case Report

“…Although ocular infection in PV patients is rare, the immunocompromised status in these patients with other medical conditions results in increased susceptibility to infection. Fungal keratitis and bilateral herpetic keratitis associated with corticosteroid treatment have been reported as ocular infection in pemphigus patients [1, 2, 3].…”