Pemphigus végétant

Spectacular Improvement of Neumann Pemphigus Vegetans, Treated with Erythromycin: Report of a Case

“…Some studies have suggested that in P Veg there are additional, occasionally detected antibodies, which bind to other desmosomal proteins, such as desmocollins 1 and 2, and periplakin. This could be a possible explanation for the differences in clinical appearance between PV and P Veg [3].…”

“…Oral involvement is exceedingly common (60 %) often since the beginning of the disease (75%), leading sometimes to malnutrition [3,7]. Oral vegetations are rare, especially in the Neumann form, but occasionally the tongue develops a 'cerebriform' appearance which is typical of this condition [2].…”

“…Under discussion are also immunopathological factors such as Th-2-mediated immune reaction and cytokines that play a role in the epithelial proliferation and eosinophils chemotaxis. Then, activation of the complement cascade in skin lesions attracts inflammatory cells, including polymorphonuclear leukocytes, which cause a severe inflammatory response, with the formation of intraepidermal abscesses and vegetative lesions, both characteristic of P Veg [2,3].…”