Pemphigus vulgaris in adolescence

Gorsky, Meir; Raviv, Mili; Raviv, Eli

doi:10.1016/0030-4220(94)90322-0

Cited by 26 publications

(6 citation statements)

References 17 publications

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“…This may even be the case for children, as the only childhood mortality seen in the cases reported here was due to pneumonia and septicemia 17 . Only 21 childhood cases have been treated with oral corticosteroids as the solitary systemic immunosuppressive treatment, all with favorable results 4 , 18–34 . Cushing’s syndrome, growth retardation, and infection are the most common side‐effects in children.…”

Section: Treatmentmentioning

confidence: 84%

Childhood, neonatal, and stillborn pemphigus vulgaris

1999

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Section: Treatmentmentioning

confidence: 84%

Childhood, neonatal, and stillborn pemphigus vulgaris

1999

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“…1,12 Pemphigus vulgaris is mainly a disease of adults and is uncommon in children and young adults. 6,13,14 There is a fairly strong genetic background to pemphigus; certain ethnic groups, such as Ashkenazian Jews and those of Mediterranean origin are especially liable to pemphigus. 15 Pemphigus is an autoimmune disorder in which there is damage to desmosomes, leading to intraepithelial vesiculation.…”

Section: Discussionmentioning

confidence: 99%

Gingival Lesions Diagnosed as Pemphigus Vulgaris in an Adolescent. Case Report

Navarro

Sposto

Onofre

et al. 1999

Journal of Periodontology

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Desquamative gingivitis (DG) is a fairly common disorder in which the gingivae show chronic desquamation. Originally considered to be related to hormonal changes at menopause, since many of the patients are middle-aged women, DG is now recognized to be mainly a manifestation of a number of disorders ranging from vesiculobullous diseases to adverse reactions to a variety of chemicals or allergens. Desquamative gingivitis can be an important early clinical manifestation of serious systemic diseases such as pemphigus vulgaris. The authors present a case that illustrates the importance of a specific diagnosis in patients with desquamative gingival lesions previously treated for 6 months as classical gingivitis. Gingival biopsy showed histologic patterns typical of pemphigus vulgaris. The patient was treated with systemic and topical corticosteroids in association with miconazole. The patient is now under control with low-dose systemic corticosteroids. Proper recognition of lesions in the oral mucosa leads, in several situations, to an early diagnosis of a systemic disease.

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“…Oral lesions usually precede onset of skin lesions before the disease finally becomes manifest as generalised or multifocal PV. 1,2 In our patient oral ulcerations and erosions appeared initially. Acantholysis with excessive eosinophil infiltration was seen in esophageal and oral biopsy specimens, and deposits of IgG and C3 were seen in the intracellular space of esophageal mucosal specimens.…”

Section: Discussionmentioning

confidence: 49%

“…Antidesmoglein antibody acts against intercellular bridges (desmoglein‐3, against those in mucous membranes; desmoglein‐1, against those in skin). Oral lesions usually precede onset of skin lesions before the disease finally becomes manifest as generalised or multifocal PV 1,2 …”

Section: Discussionmentioning

confidence: 99%

Pemphigus vulgaris as a possible cause of protein‐losing gastroenteropathy: A case report

Ishige

Kaneko

Suzuki

et al. 2008

J Paediatrics Child Health

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We present a case of pemphigus vulgaris (PV) accompanied with protein-losing gastroenteropathy (PLE). A 9-year-old girl developed multiple oral ulcerations and erosions. She was first treated with oral antibiotics and a topical steroid without improvement. Laboratory data showed eosinophilia (absolute eosinophil count 1.08 x 10(9)/L) and hypoproteinemia (total serum protein 3.9 g/dL, albumin 2.2 g/dL). A biopsy specimen from the ileum showed intense eosinophil infiltration and albumin scintigraphy demonstrated protein exduation from the same site. Endoscopic examination of the oesophagus showed multiple ulcerations and erosions, and biopsy specimen showed eosinophilic spongiosis and immunohistologic staining demonstrated deposits of IgG and C3 in the intercellular space. Antidesmoglein-3 antibody elevated, she was diagnosed as PV complicated with PLE. Immunofluorescence study of a biopsy specimen from the terminal ileum showed no significant immunoglobulin or complement deposition, and autoantibody against intestinal mucosa was unclear in this case. Gastrointestinal evaluations should be considered in patients with hypoproteinemia associated with PV.

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Pemphigus vulgaris in adolescence

Cited by 26 publications

References 17 publications

Childhood, neonatal, and stillborn pemphigus vulgaris

Childhood, neonatal, and stillborn pemphigus vulgaris

Gingival Lesions Diagnosed as Pemphigus Vulgaris in an Adolescent. Case Report

Pemphigus vulgaris as a possible cause of protein‐losing gastroenteropathy: A case report

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