Pemphigus vulgaris precipitated by glibenclamide therapy

Paterson, Andrew James; Pj, Lamey; Lewis, Michael Alexander Oxenham; Nolan, Anita; Rademaker, Marius

doi:10.1111/j.1600-0714.1993.tb00051.x

Cited by 22 publications

(6 citation statements)

References 28 publications

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“…Allergic reactions, leukocytoclastic vasculitis, erythema multiforme and psoriasiform drug eruption have been described to the biguanide drug metformin 111–114 . Furthermore, pemphigus vulgaris and psoriasiform drug eruption have been reported to the sulfonylurea glibenclamide 115–117 . It should be beared in mind that most of the sulfonylureas induce cutaneous photosensitivity 118 .…”

Section: Skin Complications Due To Therapy Of Diabetesmentioning

confidence: 99%

“…[111][112][113][114] Furthermore, pemphigus vulgaris and psoriasiform drug eruption have been reported to the sulfonylurea glibenclamide. [115][116][117] It should be beared in mind that most of the sulfonylureas induce cutaneous photosensitivity. 118 An acute generalized exanthematous pustulosis and generalized erythema Journal of the European Academy of Dermatology and Venereology ª 2012 European Academy of Dermatology and Venereology multiforme have been previously described likely to acarbose.…”

Section: Cutaneous Reactions To Oral Antidiabetic Agentsmentioning

confidence: 99%

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Skin signs in diabetes mellitus

Behm

Schreml

Landthaler

et al. 2012

Acad Dermatol Venereol

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Diabetes mellitus is the most common endocrine disorder with continuously increasing prevalence. Blood vessels, nerves, eyes, kidneys and skin are affected, which causes both an enormous financial burden and a reduced quality of life of the affected patients. Long-standing diabetes may impair skin homeostasis resulting in skin manifestations in at least one third of all diabetics. The skin involvement may be the first presenting sign of diabetes, thus the respective skin signs should lead to diabetes focused diagnostic. Besides, the skin signs may be considered as a marker for the course of the disease or for the success of therapeutic interventions.

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Section: Skin Complications Due To Therapy Of Diabetesmentioning

confidence: 99%

Section: Cutaneous Reactions To Oral Antidiabetic Agentsmentioning

confidence: 99%

Skin signs in diabetes mellitus

Behm

Schreml

Landthaler

et al. 2012

Acad Dermatol Venereol

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“…The main objective of this study was to estimate patient survival following the diagnosis of pemphigus within a group of patients in Kerman, in the south of Iran. In addition, the following variables were evaluated for their association with survival: age, sex, type of pemphigus and treatment method 1,6–12 . Determination of median survival of patients with different types of pemphigus is important both for educational purposes and for determining prognosis and survival time for the patients.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the following variables were evaluated for their association with survival: age, sex, type of pemphigus and treatment method. 1,[6][7][8][9][10][11][12] Determination of median survival of patients with different types of pemphigus is important both for educational purposes and for determining prognosis and survival time for the patients. Pemphigus has been reported more frequently in persons of Jewish ancestry, who have a lower rate of nonrelative marriages.…”

Section: Introductionmentioning

confidence: 99%

Determination of survival and hazard functions for pemphigus patients in Kerman, a southern province of Iran

Shamsadini¹,

Fekri²,

Esfandiarpoor³

et al. 2005

Int J Dermatology

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“…However, glibenclamide is the only sulphonylurea reported to cause pemphigus vulgaris (Paterson et al 1993). Blood dyscrasias are reported but are very rare.…”

Section: Other Idiosyncratic Effectsmentioning

confidence: 98%

Problems and Pitfalls of Sulphonylurea Therapy in Older Patients

Robertson

Home

1993

Drugs & Aging

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The prevalence of non-insulin-dependent diabetes mellitus (type II) increases with age, so that approximately half of all known patients in English-speaking countries are over 65 years of age. There is no reason to believe that the criteria for blood glucose control should be any less stringent for elderly patients unless they have a limited life expectancy. Sulphonylurea drugs remain an effective means of achieving blood glucose control after failure of dietary therapy alone in older patients. However, changes in normal metabolism of drugs with age and the development of other pathologies in elderly patients make it important that these drugs are prescribed with care. Severe symptomatic hypoglycaemia is the most serious adverse effect of sulphonylurea drugs and this becomes progressively more likely with increasing age, depending primarily on the substantial reduction of renal function with normal aging. Other adverse effects are much less commonly of clinical importance. To minimise the risk of hypoglycaemia, it is important that patients receive closely supervised dietary management with education about their disease for at least 3 months before sulphonylurea drugs are prescribed. In elderly patients a short-acting agent with no active metabolites should be used. As patients become older, those receiving long-acting agents can be changed to short-acting agents before problems arise. If blood glucose control appears satisfactory on treatment, then symptoms of hypoglycaemia should be sought. If control is poor, then the criteria for introduction of insulin, with appropriate education, do not differ from those in younger patients.

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Pemphigus vulgaris precipitated by glibenclamide therapy

Cited by 22 publications

References 28 publications

Skin signs in diabetes mellitus

Skin signs in diabetes mellitus

Determination of survival and hazard functions for pemphigus patients in Kerman, a southern province of Iran

Problems and Pitfalls of Sulphonylurea Therapy in Older Patients

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