Pendrin: linking acid base to blood pressure

Renal Intercalated Cell Differentiation and Acid–Base Regulation

“…Furthermore, type A intercalated cells express the kidney isoform of the basolateral anion exchanger AE1, while type B intercalated cells have the luminally localized anion exchanger pendrin. 1,2 This simplifying classification of cell types, however, has been challenged by many findings over the past 1 or 2 decades showing that intercalated cells also contribute to salt and potassium homeostasis and that multiple pathways exist through which the different cell types communicate with each other. Furthermore, the relative abundance of these three major cell types along the different segments of the collecting duct system changes under various conditions, such as use of diuretics, changes in acid-base status, or with drugs such as lithium, revealing a large plasticity of the collecting duct system.…”