Penetrating trauma: Relationships to recreational drug and alcohol use

Marco, Catherine A.; Sich, Melanie; Ganz, Ellie; Clark, Ashley N.J.; Graham, Mitchell

doi:10.1016/j.ajem.2021.11.035

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…In contrast, women consume about 7 L/year [ 27 ], but such a pattern of global alcohol consumption has been modified, since women have augmented alcohol drinking over the years in amounts that are increasingly closer to men [ 28 ]. Of particular interest is the co-ingestion of alcohol with other drugs by abusers [ 2 , 10 , 13 ].…”

Section: Epidemiological Features Of Ethanol Plus Ketamine Consumptionmentioning

confidence: 99%

“…According to the World Health Organization (2014), the harmful use of ethanol is responsible for about 5.9% of deaths in the world, as a consequence of traffic accidents, social interaction problems, domestic violence, crimes, public disorder, and chronic health problems [ 7 , 8 , 9 ]. Moreover, the consumption of alcohol is a factor that can lead to the consumption of additional psychoactive drugs, such as methylenedioxymethamphetamine (MDMA), methamphetamine, lysergic acid diethylamide (LSD), gamma-hydroxybutyrate (GHB), and especially ketamine, which has been in evidence among drug abusers [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Ketamine plus Alcohol: What We Know and What We Can Expect about This

Kobayashi

Farias

Luz

et al. 2022

IJMS

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Drug abuse has become a public health concern. The misuse of ketamine, a psychedelic substance, has increased worldwide. In addition, the co-abuse with alcohol is frequently identified among misusers. Considering that ketamine and alcohol share several pharmacological targets, we hypothesize that the consumption of both psychoactive substances may synergically intensify the toxicological consequences, both under the effect of drugs available in body systems and during withdrawal. The aim of this review is to examine the toxicological mechanisms related to ketamine plus ethanol co-abuse, as well the consequences on cardiorespiratory, digestive, urinary, and central nervous systems. Furthermore, we provide a comprehensive discussion about the probable sites of shared molecular mechanisms that may elicit additional hazardous effects. Finally, we highlight the gaps of knowledge in this area, which deserves further research.

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Section: Epidemiological Features Of Ethanol Plus Ketamine Consumptionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ketamine plus Alcohol: What We Know and What We Can Expect about This

Kobayashi

Farias

Luz

et al. 2022

IJMS

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“…While past studies had shown that male alcohol consumption and use disorder was higher compared to females, newer studies are showing that younger populations have less of a gender gap, with frequent binge drinking increasing in younger females 9 . With recent reports of incidence of alcohol use rising 10 , more research needs to be done to make up for this public health dilemma 6 . However, there is limited information regarding this topic.…”

Section: Introductionmentioning

confidence: 99%

Trends and outcomes of Alcoholic Intoxication in Trauma Patients

Yeganeh

Cuervo

Rahimi

et al. 2022

Preprint

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Background:We sought to investigate the rate and trends of alcohol intoxication in different ages and sexes during last decade.Methods:Multivariate analysis was used to compare alcohol intoxication in different sexes and age groups and to investigate the trends present during the 2007-2019 period using TQP database.Results:We found 1,000,578 intoxicated trauma patients admitted to level I-III trauma centers during 2007-2019 within TQP database. Overall, 21.7% of intoxicated patients were women. The rate of intoxicated women increased significantly from 20.6% in 2007 to 33% in 2019. Intoxicated women have a significantly higher rate of self-inflicted trauma compared to intoxicated men (10.4% vs. 2.4%, P<0.01). Overall, 29.7% of intoxicated trauma patients had chronic alcohol abuse and the rate increased by age. Chronic alcohol abuse was higher in men (30.1% vs. 28.2%, OR: 1.09, CI:1.08-1.10, P<0.01) and elderly patients (age≥65) (39.8% vs. 28.9%, OR:1.62, CI: 1.60-1.65, P<0.01). Overall mortality for intoxicated trauma patients was 2.8%. Mortality of intoxicated men was higher than women (2.9% vs. 2.2%, OR: 1.32, CI: 1.28-1.37, P<0.01). Elderly intoxicated patients (age≥65) had a significantly higher mortality (4.9% vs. 2.6%, OR: 1.91, CI: 1.84-1.98, P<0.01). Also, elderly men had twice the mortality risk compared to elderly women (5.7% vs. 3%, OR: 1.96, CI: 1.80-2.14).Conclusion:There is a gradual increase in the rate of alcoholic intoxication in women with trauma during 2007-2019. Intoxicated women have a significantly higher rate of self-inflicted trauma compared to intoxicated men. Elderly patients with alcoholic intoxication, especially men, have a higher mortality. Further studies are needed to investigate preventive strategies for the increasing rate of alcoholic intoxication in women.

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