Penetration of doripenem into prostatic tissue following intravenous administration in prostatectomy patients

Yamada, Yoshiaki; Ikawa, Kazuro; Nakamura, Kogenta; Mitsui, Kenji; Narushima, Mitsunaga; Hibi, Hatsuki; Ikeda, Kayo; Morikawa, Norifumi; Honda, Nobuaki

doi:10.1016/j.ijantimicag.2010.01.008

Cited by 6 publications

(2 citation statements)

References 13 publications

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“…3,7 To a 200-ml aliquot of a plasma sample, 200 ml of 1 mol/l 3-morpholino-propanesulfonic acid (MOPS) buffer (pH 7.0) was added. The whole volume was then pipetted into a centrifugal filter and centrifuged, after which a 20-ml aliquot of the filtrate was injected into the HPLC equipment.…”

Section: Measurement Of Doripenem Concentrations In Plasma and Prostamentioning

confidence: 99%

“…We preliminarily reported on the penetration of this compound into prostate tissue after its intravenous administration at a dose of 500 mg (n59). 3 Since doripenem shows a time-dependent antimicrobial effect, an appropriate dosing regimen should be selected on the basis of the time above the minimum inhibitory concentration (T.MIC) 4-6 at the target site, prostate tissue, where the effect is highly correlated with T.MIC. Therefore, the present study was conducted in patients who received doripenem and subsequently underwent transurethral resection of the prostate (TUR-P), to determine the time course changes of doripenem concentration in prostate tissue by monitoring its concentrations in plasma and prostate tissue over time, and also to determine the penetration of this compound into prostate tissue from the systemic circulation and its detailed pharmacokinetic properties in prostate tissue by analysing its measured concentrations.…”

Section: Introductionmentioning

confidence: 99%

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Determination of doripenem penetration into human prostate tissue and assessment of dosing regimens for prostatitis based on site-specific pharmacokinetic–pharmacodynamic evaluation

Nakamura

Ikawa

Yamada

et al. 2012

Journal of Chemotherapy

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Prostatic hypertrophy patients prophylactically received a 0.5-hour infusion of doripenem (250 or 500 mg) before transurethral resection of the prostate. Doripenem concentrations in plasma and prostate tissue were measured chromatographically, and analysed pharmacokinetically using a three-compartment model. The approved doripenem regimens were assessed based on the time above the minimum inhibitory concentration for bacteria (T>MIC, % of 24 hours), an indicator for antibacterial effects, at the prostate. The prostate tissue/plasma ratios were 17.3% for the maximum drug concentration and 18.7% for the area under the drug concentration-time curve, and they were irrespective of the dose. Against Escherichia coli and Klebsiella species isolates, 500 mg once daily achieved a >90% probability of attaining the bacteriostatic target (20% T>MIC) in prostate tissue, and 500 mg twice daily achieved a >90% probability of attaining the bactericidal target (40% T>MIC) in prostate tissue.

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Section: Measurement Of Doripenem Concentrations In Plasma and Prostamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determination of doripenem penetration into human prostate tissue and assessment of dosing regimens for prostatitis based on site-specific pharmacokinetic–pharmacodynamic evaluation

Nakamura

Ikawa

Yamada

et al. 2012

Journal of Chemotherapy

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Carbapénèmes

Grall¹,

Muller-Serieys²

2013

EMC - Maladies infectieuses

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Penetration of Doripenem into Skeletal Muscle and Subcutaneous Adipose Tissue in Healthy Volunteers

Burian

Zeitlinger

Donath

et al. 2012

Antimicrob Agents Chemother

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Sufficient antibiotic concentrations at the infection site are a prerequisite for good bacterial killing. This study was performed to determine pharmacokinetics of doripenem in soft tissues and saliva. Six healthy male volunteers received a single intravenous infusion of 500 mg doripenem over 1 h. The concentrations of doripenem were measured over 8 h in saliva, plasma, and extracellular space fluid of skeletal muscle and subcutaneous adipose tissue employing in vivo microdialysis. Unbound drug concentrations were determined using ultra-high-performance liquid chromatography-tandem mass spectrometry. Maximum concentrations of doripenem were 15.3 ؎ 6.0 mg/liter in plasma, 9.9 ؎ 2.3 mg/liter in subcutaneous adipose tissue, 6.6 ؎ 2.9 mg/liter in skeletal muscle, and 0.

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Penetration of doripenem into prostatic tissue following intravenous administration in prostatectomy patients

Cited by 6 publications

References 13 publications

Determination of doripenem penetration into human prostate tissue and assessment of dosing regimens for prostatitis based on site-specific pharmacokinetic–pharmacodynamic evaluation

Determination of doripenem penetration into human prostate tissue and assessment of dosing regimens for prostatitis based on site-specific pharmacokinetic–pharmacodynamic evaluation

Carbapénèmes

Penetration of Doripenem into Skeletal Muscle and Subcutaneous Adipose Tissue in Healthy Volunteers

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