Penetration of the skull base by dissecting keratocyst

Jackson, Ian T.; Potparić, Zoran; Fasching, Michael; Schievink, Wouter I.; Tidstrom, Kyle; Hussain, Karim

doi:10.1016/s1010-5182(05)80490-1

Cited by 64 publications

(41 citation statements)

References 21 publications

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“…Non aggressive Ameloblastoma (9) Radicular cysts (10) Odontogenic keratocyst (7) Dentigerous cysts (2) Radicular cyst (1)* Adenomatoid odontogenic tumor (1) *This particular radicular cyst was an extensive lesion extending from the maxillary canine to the third molar extending into and destroying the maxillary sinus and had caused root resorption from canine to second molar without causing any bony expansion. The initial clinical impression was that of a malignancy arising in the maxillary sinus…”

Section: Locally Aggressivementioning

confidence: 99%

“…[1] It is well-established that the cysts of histologenic labeling of odontogenic keratocyst (OKC) are more aggressive tending to behave more like a sub-malignant tumor. [1][2][3][4][5][6] It has also been suggested that cysts other than OKC showing keratinization if not more locally aggressive tend to have a predisposition to neoplastic change. [7] There have been attempts to correlate follicle size with aggression in ameloblastoma, and morphologically different granular cell variant has been known to be more clinically aggressive, showing metastatic potential.…”

Section: Introductionmentioning

confidence: 99%

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The expression of cathepsin-D in odontogenic cysts and tumors: Immunohistochemistry study

Lakkasetty¹,

Venkatraman²,

Balasundarishreedhar³

et al. 2015

JCRI

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Background: Cathepsin-D, a protease, which is an invasion promoter and plays a central role in solid tumors including oral cancer. Our aim of the study was to look for their expression pattern in epithelium and stroma of odontogenic cysts and tumors and correlate their aggressiveness to the staining intensity. Materials and Methods:To elucidate the expression patterns of this marker, we examined immunohistochemically on formalin-fixed, paraffin-embedded sections of 24 odontogenic cysts and 10 odonogenic tumors, which are received for histopathologic examination in the Department of Oral Pathology, The Oxford Dental College and Hospital, Bengaluru. Results:The epithelium of granular cell ameloblastoma (GCA) and odontogenic keratocyst (OKC) showed maximum staining with spillage of stained material in the connective tissue wall and at the separation of epithelium to capsule in OKC compared to other cysts and tumors. Conclusions: Cathepsin-D could be one of the enzymes important in separation of epithelium and connective tissue in OKC which helps in recurrence and intense expression in GCA with spillage into stroma, compared to other odontogenic tumors may explain its aggressive behavior, recurrence, and metastatic potential. To further validate our findings, it is suggested to use more sample size and monoclonal antibody for cathepsin-D.

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Section: Locally Aggressivementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The expression of cathepsin-D in odontogenic cysts and tumors: Immunohistochemistry study

Lakkasetty¹,

Venkatraman²,

Balasundarishreedhar³

et al. 2015

JCRI

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“…In 1994 Jackson et al [6] reported 2 cases of OKC which invaded and penetrated the skull base and led to the death of one of the patients. The authors emphasize that ''complete excision should be carried out once these unpredictable lesions show any sign of soft tissue involvement.…”

Section: Introductionmentioning

confidence: 99%

Keratocystic Odontogenic Tumor (KCOT/OKC)—Clinical Guidelines for Resection

Warburton

Shihabi

Ord

2015

J. Maxillofac. Oral Surg.

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Purpose There is no clinical consensus for the treatment of Keratocystic Odontogenic Tumor (KCOT). KCOTs are regarded as benign aggressive tumors and resection is usually considered as a last option. We review the clinical indications for resection based on a case series. Methods This is a retrospective study of patients with KCOT treated in a single unit over 17 years. Eighty patients were identified, of which 12 (15 %) underwent resection. The remaining 68 patients were managed by enucleation and curettage, enucleation with peripheral ostectomy, or decompression with secondary enucleation. Data extracted includes gender, age, race, location, previous treatment for the lesion, surgery and outcome/ follow up. Results Twelve patients treated by resection were identified. The location in the ten benign resected KCOTs was either the mandibular ramus or the posterior maxilla. All mandibular KCOTs exhibited perforation of the lingual plate and involvement of the pterygoid musculature. Seven of the ten cases were recurrent KCOTs and three had no prior treatment. Two had malignant changes in the KCOT and were also resected. Conclusion The primary reason for resection of KCOT was involvement of the pterygoid muscles. The presence of malignant change was a separate indication for resection.

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“…It was first described by Philipsen in 1956. 1 Odontogenic keratocysts arise from the remnants of dental lamina, also known as rests of Serres. Odontogenic keratocysts present as slow growing non specific cysts.…”

Section: Discussionmentioning

confidence: 99%

“…2 Odontogenic keratocysts occurring in the soft tissue of skull are usually caused by erosion of cortical plate of bone by aggressive lesions which extend into the soft tissues, skull base, zygoma, lateral orbital rim and temporalis muscle or recurrences after initial surgery. 1,7 Odontogenic keratocysts of the infratemporal fossa usually are from extensions from the maxilla 7 and very rarely from the coronoid process of the mandible. 1 Primary extra osseous odontogenic keratocysts have only been rarely reported and present as gingival cysts.…”

Section: Discussionmentioning

confidence: 99%